SU-C-204-04: Patient Specific Proton Stopping Powers Estimation by Combining Proton Radiography and Prior-Knowledge X-Ray CT Information
- Massachussetts General Hospital, Quebec, Quebec (Canada)
- Ion Beam Application, Louvain-la-neuve (Belgium)
- Aarhus University, Aarhus, Aarhus (Denmark)
- Centre Hospitalier Univ de Quebec, Quebec, QC (Canada)
- Mass General Hospital, Harvard Medical, Boston, MA (United States)
Purpose: The material relative stopping power (RSP) uncertainty is the highest contributor to the range uncertainty in proton therapy. The purpose of this work is to develop a robust and systematic method that yields accurate, patient specific, RSP by combining 1) pre-treatment x-ray CT and 2) daily proton radiograph of the patient. Methods: The method is formulated as a linear least-square optimization problem (min||Ax-B||2). The parameter A represents the pathlength crossed by the proton in each material. The RSPs for the materials (water equivalent thickness (WET)/physical thickness) are denoted by x. B is the proton radiograph expressed as WET crossed. The problem is minimized using a convex-conic optimization algorithm with xi
- OSTI ID:
- 22486569
- Journal Information:
- Medical Physics, Vol. 42, Issue 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-2405
- Country of Publication:
- United States
- Language:
- English
Similar Records
SU-C-204-02: Improved Patient-Specific Optimization of the Stopping Power Calibration for Proton Therapy Planning Using a Single Proton Radiography
SU-E-T-391: Evaluation of Image Parameters Impact On the CT Calibration Curve for Proton Therapy