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Title: Radioembolization Dosimetry: The Road Ahead

Methods for calculating the activity to be administered during yttrium-90 radioembolization (RE) are largely based on empirical toxicity and efficacy analyses, rather than dosimetry. At the same time, it is recognized that treatment planning based on proper dosimetry is of vital importance for the optimization of the results of RE. The heterogeneous and often clustered intrahepatic biodistribution of millions of point-source radioactive particles poses a challenge for dosimetry. Several studies found a relationship between absorbed doses and treatment outcome, with regard to both toxicity and efficacy. This should ultimately lead to improved patient selection and individualized treatment planning. New calculation methods and imaging techniques and a new generation of microspheres for image-guided RE will all contribute to these improvements. The aim of this review is to give insight into the latest and most important developments in RE dosimetry and to suggest future directions on patient selection, individualized treatment planning, and study designs.
Authors:
;  [1] ;  [2] ;  [3] ;  [1] ;  [4] ; ; ;  [1]
  1. University Medical Center Utrecht, Department of Radiology and Nuclear Medicine (Netherlands)
  2. Stanford University School of Medicine, Division of Interventional Radiology (United States)
  3. Austin Hospital, Department of Nuclear Medicine (Australia)
  4. Stanford University School of Medicine, Division of Nuclear Medicine and Molecular Imaging (United States)
Publication Date:
OSTI Identifier:
22470026
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 38; Journal Issue: 2; Conference: BSIR 2014: Britisch Society of Interventional Radiology 2014 annual meeting, Liverpool (United Kingdom), 12-14 Nov 2014; Other Information: Copyright (c) 2015 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABSORBED RADIATION DOSES; BIOMEDICAL RADIOGRAPHY; DOSIMETRY; IMAGES; LEAD; MICROSPHERES; OPTIMIZATION; PARTICLES; PATIENTS; PLANNING; POINT SOURCES; RADIOEMBOLIZATION; REVIEWS; TOXICITY; YTTRIUM 90