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Title: Strenuous exercise induces mitochondrial damage in skeletal muscle of old mice

Strenuous exercise is known to cause excessive ROS generation and inflammation. However, the mechanisms responsible for the regulation of mitochondrial integrity in the senescent muscle during high-intensity exercise (HE) are not well studied. Here, we show that HE suppresses up-regulation of mitochondrial function despite increase in mitochondrial copy number, following excessive ROS production, proinflammatory cytokines and NFκB activation. Moreover, HE in the old group resulted in the decreasing of both fusion (Mfn2) and fission (Drp1) proteins that may contribute to alteration of mitochondrial morphology. This study suggests that strenuous exercise does not reverse age-related mitochondrial damage and dysfunction by the increased ROS and inflammation. - Highlights: • Effect of exercise on mitochondrial function of aged skeletal muscles was studied. • Strenuous exercise triggered excessive ROS production and inflammatory cytokines. • Strenuous exercise suppressed mitochondrial function in senescent muscle.
Authors:
;  [1] ;  [2] ;  [1] ;  [1] ;  [3]
  1. Department of Physical Education, Hankuk Univrsity of Foreign Studies, Seoul 130-791 (Korea, Republic of)
  2. Department of Sports Medicine, College of Health Science, Cheongju University, Cheongju 363-764 (Korea, Republic of)
  3. (United States)
Publication Date:
OSTI Identifier:
22462063
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 461; Journal Issue: 2; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; DAMAGE; ELDERLY PEOPLE; EXERCISE; FISSION; INFLAMMATION; LYMPHOKINES; MICE; MITOCHONDRIA; MORPHOLOGY; MUSCLES