Fluctuating hydrodynamics of multicomponent membranes with embedded proteins

Journal Article · Thu Aug 21 00:00:00 EDT 2014 · Journal of Chemical Physics

DOI:https://doi.org/10.1063/1.4892802· OSTI ID:22419813

Camley, Brian A. ^[1]; Brown, Frank L. H., ^[2]

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1. Department of Physics and Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, California 92093 (United States)
2. Department of Physics, University of California, Santa Barbara, Santa Barbara, California 93106 (United States)

A simulation method for the dynamics of inhomogeneous lipid bilayer membranes is presented. The membrane is treated using stochastic Saffman-Delbrück hydrodynamics, coupled to a phase-field description of lipid composition and discrete membrane proteins. Multiple applications are considered to validate and parameterize the model. The dynamics of membrane composition fluctuations above the critical point and phase separation dynamics below the critical point are studied in some detail, including the effects of adding proteins to the mixture.

• OSTI ID: 22419813
• Journal Information: Journal of Chemical Physics, Vol. 141, Issue 7; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0021-9606
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
FLUCTUATIONS
HYDRODYNAMICS
LIPIDS
MEMBRANE PROTEINS
MEMBRANES
MIXTURES
SIMULATION