Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam
- Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705 and Duke Radiation Dosimetry Laboratory, Duke University Medical Center, Durham, North Carolina 27710 (United States)
- Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708 (United States)
- Department of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)
- Department of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599 and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599 (United States)
Purpose: Here, the authors describe a dosimetry measurement technique for microbeam radiation therapy using a nanoparticle-terminated fiber-optic dosimeter (nano-FOD). Methods: The nano-FOD was placed in the center of a 2 cm diameter mouse phantom to measure the deep tissue dose and lateral beam profile of a planar x-ray microbeam. Results: The continuous dose rate at the x-ray microbeam peak measured with the nano-FOD was 1.91 ± 0.06 cGy s{sup −1}, a value 2.7% higher than that determined via radiochromic film measurements (1.86 ± 0.15 cGy s{sup −1}). The nano-FOD-determined lateral beam full-width half max value of 420 μm exceeded that measured using radiochromic film (320 μm). Due to the 8° angle of the collimated microbeam and resulting volumetric effects within the scintillator, the profile measurements reported here are estimated to achieve a resolution of ∼0.1 mm; however, for a beam angle of 0°, the theoretical resolution would approach the thickness of the scintillator (∼0.01 mm). Conclusions: This work provides proof-of-concept data and demonstrates that the novel nano-FOD device can be used to perform real-time dosimetry in microbeam radiation therapy to measure the continuous dose rate at the x-ray microbeam peak as well as the lateral beam shape.
- OSTI ID:
- 22413522
- Journal Information:
- Medical Physics, Vol. 42, Issue 4; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-2405
- Country of Publication:
- United States
- Language:
- English
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