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Title: Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam

Purpose: Here, the authors describe a dosimetry measurement technique for microbeam radiation therapy using a nanoparticle-terminated fiber-optic dosimeter (nano-FOD). Methods: The nano-FOD was placed in the center of a 2 cm diameter mouse phantom to measure the deep tissue dose and lateral beam profile of a planar x-ray microbeam. Results: The continuous dose rate at the x-ray microbeam peak measured with the nano-FOD was 1.91 ± 0.06 cGy s{sup −1}, a value 2.7% higher than that determined via radiochromic film measurements (1.86 ± 0.15 cGy s{sup −1}). The nano-FOD-determined lateral beam full-width half max value of 420 μm exceeded that measured using radiochromic film (320 μm). Due to the 8° angle of the collimated microbeam and resulting volumetric effects within the scintillator, the profile measurements reported here are estimated to achieve a resolution of ∼0.1 mm; however, for a beam angle of 0°, the theoretical resolution would approach the thickness of the scintillator (∼0.01 mm). Conclusions: This work provides proof-of-concept data and demonstrates that the novel nano-FOD device can be used to perform real-time dosimetry in microbeam radiation therapy to measure the continuous dose rate at the x-ray microbeam peak as well as the lateral beam shape.
Authors:
 [1] ; ; ;  [2] ; ; ;  [3] ;  [4] ;  [3] ;  [5] ;  [5] ;  [6] ;  [5] ;  [5]
  1. Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705 and Duke Radiation Dosimetry Laboratory, Duke University Medical Center, Durham, North Carolina 27710 (United States)
  2. Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708 (United States)
  3. Department of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)
  4. Department of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599 and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599 (United States)
  5. (United States)
  6. Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705 (United States)
Publication Date:
OSTI Identifier:
22413522
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 42; Journal Issue: 4; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BEAM PROFILES; DOSEMETERS; DOSIMETRY; MICE; PHANTOMS; RADIATION DOSES; RADIOTHERAPY; X RADIATION