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Title: Synthesis and characterization of Bi{sub 2}S{sub 3} composite nanoparticles with high X-ray absorption

Graphical abstract: - Highlights: • Uniform Bi{sub 2}S{sub 3} nanorods were prepared via a hot injection method. • Bi{sub 2}S{sub 3} nanorods were coated with TEOS and PEG for surface modification. • CT images of Bi{sub 2}S{sub 3}@SiO{sub 2}-PEG are much higher than clinical iobitridol when they have the same concentration. • Cellular toxicity of Bi{sub 2}S{sub 3}@SiO{sub 2}-PEG is low when the probes were directly in contact with tissue fluid. - Abstract: Owing to the high X-ray absorption, Bi{sub 2}S{sub 3} nanocrystals are widely used as CT contrast agents. Here, we prepared uniform Bi{sub 2}S{sub 3} nanorods via a hot injection method using bismuth (III) chloride, sulfur and oleyl amine. The resulting nanocrystals were coated with tetraethylorthosilicate (TEOS) and 2-[methoxy(polyethyleneoxy)propyl]yrimethoxysilane (PEG-silane) for the biological utility. X-ray diffraction (XRD) and transmission electron microscopy (TEM) results showed that the Bi{sub 2}S{sub 3} nanorods had an orthorhombic structure with the length of 14 nm and the diameter of 7 nm, respectively. Composite nanoparticles (0.0226 M) gave a CT number at 550 (HU), which was higher than that of the commercial available iobitridol CT contrast agent. Furthermore, cell experiments revealed that Bi{sub 2}S{sub 3} composite nanoparticles had a low cytotoxicity with a concentrationmore » up to 0.01 M of Bi for 24 h.« less
Authors:
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Publication Date:
OSTI Identifier:
22285108
Resource Type:
Journal Article
Resource Relation:
Journal Name: Materials Research Bulletin; Journal Volume: 48; Journal Issue: 10; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; ABSORPTION; BISMUTH; BISMUTH SULFIDES; CHLORIDES; CONCENTRATION RATIO; NANOSTRUCTURES; ORTHORHOMBIC LATTICES; PHOTOELECTRON SPECTROSCOPY; SILICA; SILICON OXIDES; SURFACE PROPERTIES; SYNTHESIS; X-RAY DIFFRACTION