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Title: Optically detected, single nanoparticle mass spectrometer with pre-filtered electrospray nanoparticle source

An instrument designed for non-destructive mass analysis of single trapped nanoparticles is described. The heart of the instrument is a 3D quadrupole (Paul) trap constructed to give optical access to the trap center along ten directions, allowing passage of lasers for particle heating and detection, particle injection, collection of scattered or fluorescent photons for particle detection and mass analysis, and collection of particles on TEM grids for analysis, as needed. Nanoparticles are injected using an electrospray ionization (ESI) source, and conditions are described for spraying and trapping polymer particles, bare metal particles, and ligand stabilized particles with masses ranging from 200 kDa to >3 GDa. Conditions appropriate to ESI and injection of different types of particles are described. The instrument is equipped with two ion guides separating the ESI source and nanoparticle trap. The first ion guide is mostly to allow desolvation and differential pumping before the particles enter the trap section of the instrument. The second is a linear quadrupole guide, which can be operated in mass selective or mass band-pass modes to limit transmission to species with mass-to-charge ratios in the range of interest. With a little experience, the design allows injection of single particles into the trapmore » upon demand.« less
Authors:
; ;  [1]
  1. Chemistry Department, University of Utah, 315 S. 1400 E, Salt Lake City, Utah 84112 (United States)
Publication Date:
OSTI Identifier:
22251143
Resource Type:
Journal Article
Resource Relation:
Journal Name: Review of Scientific Instruments; Journal Volume: 85; Journal Issue: 1; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; DESIGN; FLUORESCENCE; HEATING; IONIZATION; LASERS; LIGANDS; MASS SPECTROMETERS; MINUS-PLUS RATIO; NANOSTRUCTURES; PARTICLES; PHOTONS; POLYMERS; RADIATION DETECTION; TRANSMISSION ELECTRON MICROSCOPY; TRAPPING; TRAPS