Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway
Abstract
Research highlights: {yields} Curcumin had anti-cancer effects on A549/DDP multidrug-resistant human lung adenocarcinoma cells {yields} Curcumin promotes apoptosis in A549/DDP cells through a miRNA signaling pathway {yields} Curcumin induces A549/DDP cell apoptosis by downregulating miR-186* {yields} miR-186* may serve as a potential gene therapy target for refractory lung cancer that is sensitive to curcumin -- Abstract: Curcumin extracted from the rhizomes of Curcuma longa L. has been shown to have inhibitory effects on cancers through its anti-proliferative and pro-apoptotic activities. Emerging evidence demonstrates that curcumin can overcome drug resistance to classical chemotherapies. Thus, the mechanisms underlying the anti-tumor activities of curcumin require further study. In our study, we first demonstrated that curcumin had anti-cancer effects on A549/DDP multidrug-resistant human lung adenocarcinoma cells. Further studies showed that curcumin altered miRNA expression; in particular, significantly downregulated the expression of miR-186* in A549/DDP. In addition, transfection of cells with a miR-186* inhibitor promoted A549/DDP apoptosis, and overexpression of miR-186* significantly inhibited curcumin-induced apoptosis in A549/DDP cells. These observations suggest that miR-186* may serve as a potential gene therapy target for refractory lung cancer that is sensitive to curcumin.
- Authors:
-
- Department of Respiratory Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032 (China)
- Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038 (China)
- The Medical Image Center, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032 (China)
- Publication Date:
- OSTI Identifier:
- 22202729
- Resource Type:
- Journal Article
- Journal Name:
- Biochemical and Biophysical Research Communications
- Additional Journal Information:
- Journal Volume: 399; Journal Issue: 1; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; APOPTOSIS; BROMIDES; CARCINOMAS; CHEMOTHERAPY; CONCENTRATION RATIO; CURCUMIN; DRUGS; GENE THERAPY; LABELLING; LUNGS; TETRAZOLIUM
Citation Formats
Zhang, Jian, Zhang, Tao, Ti, Xinyu, Shi, Jieran, Wu, Changgui, Ren, Xinling, and Yin, Hong. Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway. United States: N. p., 2010.
Web. doi:10.1016/J.BBRC.2010.07.013.
Zhang, Jian, Zhang, Tao, Ti, Xinyu, Shi, Jieran, Wu, Changgui, Ren, Xinling, & Yin, Hong. Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway. United States. https://doi.org/10.1016/J.BBRC.2010.07.013
Zhang, Jian, Zhang, Tao, Ti, Xinyu, Shi, Jieran, Wu, Changgui, Ren, Xinling, and Yin, Hong. 2010.
"Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway". United States. https://doi.org/10.1016/J.BBRC.2010.07.013.
@article{osti_22202729,
title = {Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway},
author = {Zhang, Jian and Zhang, Tao and Ti, Xinyu and Shi, Jieran and Wu, Changgui and Ren, Xinling and Yin, Hong},
abstractNote = {Research highlights: {yields} Curcumin had anti-cancer effects on A549/DDP multidrug-resistant human lung adenocarcinoma cells {yields} Curcumin promotes apoptosis in A549/DDP cells through a miRNA signaling pathway {yields} Curcumin induces A549/DDP cell apoptosis by downregulating miR-186* {yields} miR-186* may serve as a potential gene therapy target for refractory lung cancer that is sensitive to curcumin -- Abstract: Curcumin extracted from the rhizomes of Curcuma longa L. has been shown to have inhibitory effects on cancers through its anti-proliferative and pro-apoptotic activities. Emerging evidence demonstrates that curcumin can overcome drug resistance to classical chemotherapies. Thus, the mechanisms underlying the anti-tumor activities of curcumin require further study. In our study, we first demonstrated that curcumin had anti-cancer effects on A549/DDP multidrug-resistant human lung adenocarcinoma cells. Further studies showed that curcumin altered miRNA expression; in particular, significantly downregulated the expression of miR-186* in A549/DDP. In addition, transfection of cells with a miR-186* inhibitor promoted A549/DDP apoptosis, and overexpression of miR-186* significantly inhibited curcumin-induced apoptosis in A549/DDP cells. These observations suggest that miR-186* may serve as a potential gene therapy target for refractory lung cancer that is sensitive to curcumin.},
doi = {10.1016/J.BBRC.2010.07.013},
url = {https://www.osti.gov/biblio/22202729},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 1,
volume = 399,
place = {United States},
year = {Fri Aug 13 00:00:00 EDT 2010},
month = {Fri Aug 13 00:00:00 EDT 2010}
}