An evidence for adhesion-mediated acquisition of acute myeloid leukemic stem cell-like immaturities

Journal Article · Fri Feb 12 00:00:00 EST 2010 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2009.12.163· OSTI ID:22202365

Funayama, Keiji; Shimane, Miyuki; Nomura, Hitoshi ^[1]; Asano, Shigetaka ^[1]

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1. Department of Integrative Bioscience and Biomedical Engineering, Waseda University, 4-3-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555 (Japan)

For long-term survival in vitro and in vivo of acute myeloid leukemia cells, their adhesion to bone marrow stromal cells is indispensable. However, it is still unknown if these events are uniquely induced by the leukemic stem cells. Here we show that TF-1 human leukemia cells, once they have formed a cobblestone area by adhering to mouse bone marrow-derived MS-5 cells, can acquire some leukemic stem cell like properties in association with a change in the CD44 isoform-expression pattern and with an increase in a set of related microRNAs. These findings strongly suggest that at least some leukemia cells can acquire leukemic stem cell like properties in an adhesion-mediated stochastic fashion.

• OSTI ID: 22202365
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 392, Issue 3; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BONE MARROW
IN VITRO
IN VIVO
MICE
MYELOID LEUKEMIA
STEM CELLS
STOCHASTIC PROCESSES