The {gamma}-aminobutyric acid receptor {gamma}3 subunit gene (GABRG3) is tightly linked to the {alpha}5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation
- Harvard Medical School, Boston, MA (United States)
GABA{sub A} receptors are heterooligomeric ligand-gated ion channels that mediate the effect of the inhibitory neurotransmitter {gamma}-aminobutyric acid. The GABA{sub A} receptors consist of at least 15 different receptor subunits that can be classified into 5 subfamilies ({alpha},{beta},{gamma},{delta},{rho}) on the basis of sequence similarity. Chromosomal mapping studies have revealed that several of the GABA{sub A} receptor subunit genes appear to be organized as clusters. One such cluster, which consists of the GABA{sub A} receptor {beta}3 (GABRB3) and {alpha}5 (GABRA5) sub-unit genes, is located in chromosome 15q11-q13. It is shown here that the GABA{sub A} receptor {gamma}3 subunit gene (GABRG3) also maps to this region. Lambda and P1 phage clones surrounding both ends of GABRG3 were isolated; the clones derived from the 5{prime} end of GABRG3 were linked to an existing phage contig spanning the 3{prime} end of GABRA5. The two genes are located within 35 kb of each other and are transcribed in the same orientation. 39 refs., 4 figs.
- OSTI ID:
- 219888
- Journal Information:
- Genomics, Vol. 26, Issue 2; Other Information: PBD: 20 Mar 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
The human [gamma]-aminobutyric acid receptor subunit [beta]3 and [alpha]5 gene cluster in chromosome 15q11-q13 is rich in highly polymorphic (CA)[sub n] repeats
Concordance between isolated cleft palate in mice and alterations within a region including the gene encoding the [beta][sub 3] subunit of the type A [gamma]-aminobutyric acid receptor