Stability, Visibility, and Histologic Analysis of a New Implanted Fiducial for Use as a Kilovoltage Radiographic or Radioactive Marker for Patient Positioning and Monitoring in Radiotherapy

Journal Article · Thu Jul 15 00:00:00 EDT 2010 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2009.09.056· OSTI ID:21436095

Neustadter, David ^[1]; Tune, Michal ^[1]; Zaretsky, Asaph; Shofti, Rona ^[2]; Kushnir, Arnon; Harel, Tami; Carmi-Yinon, Dafna ^[1]; Corn, Ben M.S. ^[3]

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1. Navotek Medical Ltd., Yokneam (Israel)
2. Technion Israel Institute of Technology, Haifa (Israel)
3. Tel Aviv Medical Center, Tel Aviv (Israel)

Purpose: To analyze the stability, visibility, and histology of a novel implantable soft-tissue marker (nonradioactive and radioactive) implanted in dog prostate and rabbit liver. Methods and Materials: A total of 34 nonradioactive and 35 radioactive markers were implanted in 1 dog and 16 rabbits. Stability was assessed by measuring intermarker distance (IMD) variation relative to IMDs at implantation. The IMDs were measured weekly for 4 months in the dog and biweekly for 2-4 weeks in the rabbits. Ultrasound and X-ray imaging were performed on all subjects. Computed tomography and MRI were performed on the dog. Histologic analysis was performed on the rabbits after 2 or 4 months. Results: A total of 139 measurements had a mean ({+-} SD) absolute IMD variation of 1.1 {+-} 1.1 mm. These IMD variations are consistent with those reported in the literature as due to random organ deformation. The markers were visible, identifiable, and induced minimal or no image artifacts in all tested imaging modalities. Histologic analysis revealed that all pathologic changes were highly localized and not expected to be clinically significant. Conclusions: The markers were stable from the time of implantation. The markers were found to be compatible with all common medical imaging modalities. The markers caused no significant histologic effects. With respect to marker stability, visibility, and histologic analysis these implanted fiducials are appropriate for soft-tissue target positioning in radiotherapy.

• OSTI ID: 21436095
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 77, Issue 4; Other Information: DOI: 10.1016/j.ijrobp.2009.09.056; PII: S0360-3016(09)03335-5; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL MARKERS
COMPUTERIZED TOMOGRAPHY
DOGS
IMPLANTS
LIVER
NMR IMAGING
PATIENTS
POSITIONING
PROSTATE
RABBITS
RADIOTHERAPY
STABILITY
VISIBILITY
ANIMALS
BODY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
GLANDS
MALE GENITALS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
THERAPY
TOMOGRAPHY
VERTEBRATES