Attenuation of arsenic neurotoxicity by curcumin in rats

Journal Article · Sun Nov 01 00:00:00 EDT 2009 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/j.taap.2009.07.017· OSTI ID:21344776

Yadav, Rajesh S; Sankhwar, Madhu Lata; Shukla, Rajendra K; Chandra, Ramesh; Pant, Aditya B ^[1]; Islam, Fakhrul ^[2]

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1. Indian Institute of Toxicology Research, (Council of Scientific and Industrial Research, New Delhi), Post Box 80, MG Marg, Lucknow - 226 001 (India)
2. Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard, New Delhi - 110 062 (India)

In view of continued exposure to arsenic and associated human health risk including neurotoxicity, neuroprotective efficacy of curcumin, a polyphenolic antioxidant, has been investigated in rats. A significant decrease in locomotor activity, grip strength (26%) and rota-rod performance (82%) was observed in rats treated with arsenic (sodium arsenite, 20 mg/kg body weight, p.o., 28 days) as compared to controls. The arsenic treated rats also exhibited a decrease in the binding of striatal dopamine receptors (32%) and tyrosine hydroxylase (TH) immunoreactivity (19%) in striatum. Increased arsenic levels in corpus striatum (6.5 fold), frontal cortex (6.3 fold) and hippocampus (7.0 fold) associated with enhanced oxidative stress in these brain regions, as evident by an increase in lipid perioxidation, protein carbonyl and a decrease in the levels of glutathione and activity of superoxide dismutase, catalase and glutathione peroxidase with differential effects were observed in arsenic treated rats compared to controls. Simultaneous treatment with arsenic (sodium arsenite, 20 mg/kg body weight, p.o., 28 days) and curcumin (100 mg/kg body weight, p.o., 28 days) caused an increase in locomotor activity and grip strength and improved the rota-rod performance in comparison to arsenic treated rats. Binding of striatal dopamine receptors and TH expression increased while arsenic levels and oxidative stress decreased in these brain regions in co-treated rats as compared to those treated with arsenic alone. No significant effect on any of these parameters was observed in rats treated with curcumin (100 mg/kg body weight, p.o., 28 days) alone compared to controls. A significant protection in behavioral, neurochemical and immunohistochemical parameters in rats simultaneously treated with arsenic and curcumin suggest the neuroprotective efficacy of curcumin.

• OSTI ID: 21344776
• Journal Information: Toxicology and Applied Pharmacology, Vol. 240, Issue 3; Other Information: DOI: 10.1016/j.taap.2009.07.017; PII: S0041-008X(09)00300-7; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANTIOXIDANTS
ARSENIC
ATTENUATION
CATALASE
CURCUMIN
DOPAMINE
GLUTATHIONE
HYDROXYLASES
PUBLIC HEALTH
RATS
RECEPTORS
SUPEROXIDE DISMUTASE
TOXIC MATERIALS
TOXICITY
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DRUGS
DYES
ELEMENTS
ENZYMES
ETHERS
HAZARDOUS MATERIALS
HYDROXY COMPOUNDS
KETONES
MAMMALS
MATERIALS
MEMBRANE PROTEINS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXIDOREDUCTASES
PEPTIDES
PEROXIDASES
PHENOLS
POLYPEPTIDES
POLYPHENOLS
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
RODENTS
SEMIMETALS
SYMPATHOMIMETICS
VERTEBRATES