A multi-phase level set framework for source reconstruction in bioluminescence tomography

Journal Article · Thu Jul 01 00:00:00 EDT 2010 · Journal of Computational Physics

DOI:https://doi.org/10.1016/j.jcp.2010.03.041· OSTI ID:21333921

Heyu, Huang; Xiaochao, Qu; Jimin, Liang ^[1]; Xiaowei, He ^[1]; Xueli, Chen; Da'an, Yang ^[1]; Jie, Tian ^[1]

---

1. Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071 (China)

We propose a novel multi-phase level set algorithm for solving the inverse problem of bioluminescence tomography. The distribution of unknown interior source is considered as piecewise constant and represented by using multiple level set functions. The localization of interior bioluminescence source is implemented by tracing the evolution of level set function. An alternate search scheme is incorporated to ensure the global optimal of reconstruction. Both numerical and physical experiments are performed to evaluate the developed level set reconstruction method. Reconstruction results show that the proposed method can stably resolve the interior source of bioluminescence tomography.

• OSTI ID: 21333921
• Journal Information: Journal of Computational Physics, Vol. 229, Issue 13; Other Information: DOI: 10.1016/j.jcp.2010.03.041; PII: S0021-9991(10)00160-9; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0021-9991
• Country of Publication: United States
• Language: English

Related Subjects

71 CLASSICAL AND QUANTUM MECHANICS
GENERAL PHYSICS
ALGORITHMS
BIOLUMINESCENCE
DISTRIBUTION
EVOLUTION
FUNCTIONS
TOMOGRAPHY