Thiazolidinediones inhibit the growth of PC12 cells both in vitro and in vivo
- Department of Internal Medicine, Seoul National University, College of Medicine, 28 Yungun-Dong, Chongno-Gu, Seoul 110-774 (Korea, Republic of)
- Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul (Korea, Republic of)
- Department of Pathology, Seoul National University Boramae Hospital, Seoul (Korea, Republic of)
Thiazolidinediones (TZDs) have recently been proposed as a therapy for PPAR{gamma}-expressing tumors. Pheochromocytoma (PHEO) is associated with high morbidity and mortality due to excess catecholamine production, and few effective drug therapies currently exist. We investigated the effects of TZDs on PHEO both in vitro and in vivo. PPAR{gamma} protein was expressed in human adrenal PHEO tissues as well as in rat PHEO cells, PC12. TZDs, including rosiglitazone (RGZ) and pioglitazone (PGZ), inhibited proliferation of PC12 cells in a dose-dependent manner and increased casapse-3 expression of PC12 cells. TZDs also reduced expression of cyclin E and cyclin-dependent kinase2. RGZ inhibited nerve growth factor-induced neurite outgrowth and reduced expression of catecholamine-synthesizing enzymes. Finally, rat PHEO growth generated by subcutaneous injection of PC12 cells was slowed in an RGZ-treated mouse. These data suggest that TZDs may be a promising therapeutic approach for medical treatment for PHEO.
- OSTI ID:
- 21143729
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 371, Issue 2; Other Information: DOI: 10.1016/j.bbrc.2008.04.035; PII: S0006-291X(08)00666-9; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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