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Title: Upfront Chemotherapy and Involved-Field Radiotherapy Results in More Relapses Than Extended Radiotherapy for Intracranial Germinomas: Modification in Radiotherapy Volume Might Be Needed

Purpose: To retrospectively compare the outcome of upfront chemotherapy plus radiotherapy (CRT) and the outcome of the use of extended radiotherapy (RT) only for intracranial germinoma. Methods and Materials: Of 81 patients with tissue-confirmed intracranial germinoma, 42 underwent CRT and 39 underwent RT only. For CRT, one to five cycles of upfront chemotherapy was followed by involved-field or extended-field RT, for which the dose was dependent on the M stage. For RT only, all 39 patients underwent craniospinal RT alone. The median follow-up was 68 months. Results: The 5- and 10-year overall survival rate was 100% and 92.5% for RT alone and 92.9% and 92.9% for CRT, respectively. The 5-year recurrence-free survival rate was 100.0% for RT and 88.1% for CRT (p = 0.0279). No recurrences developed in patients given RT, but four relapses developed in patients who had received CRT-three in the brain and one in the spine. Only one patient achieved complete remission from salvage treatment. The proportion of patients requiring hormonal replacement was greater for patients who received RT than for those who had received CRT (p = 0.0106). Conclusions: The results of our study have shown that the better quality of life provided by CRT wasmore » compensated for by the greater rate of relapse. The possible benefit of including the ventricles in involved-field RT after upfront chemotherapy, specifically for patients with initial negative seeding, should be addressed in a prospective study.« less
Authors:
 [1] ;  [1] ;  [2] ;  [3] ; ; ; ;  [1] ; ; ; ;  [4] ;  [5] ; ; ;  [6]
  1. Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of)
  2. (Korea, Republic of)
  3. (Korea, Republic of), E-mail: ihkim@snu.ac.kr
  4. Department of Neurosurgery, Seoul National University College of Medicine, Seoul (Korea, Republic of)
  5. Department of Internal Medicine, Seoul National University College of Medicine, Seoul (Korea, Republic of)
  6. Department of Pediatrics, Seoul National University College of Medicine, Seoul (Korea, Republic of)
Publication Date:
OSTI Identifier:
21124301
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 71; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2008.01.061; PII: S0360-3016(08)00355-6; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; CHEMOTHERAPY; COMBINED THERAPY; HORMONES; PATIENTS; RADIATION DOSES; RADIOTHERAPY; VERTEBRAE