Comparative transforming potential of different human papillomaviruses associated with non-melanoma skin cancer

Journal Article · Wed Feb 20 00:00:00 EST 2008 · Virology

DOI:https://doi.org/10.1016/j.virol.2007.10.015· OSTI ID:21078022

Massimi, Paola; Thomas, Miranda ^[1]; Bouvard, Veronique ^[2]; Ruberto, Irene ^[1]; Campo, M Saveria ^[3]; Tommasino, Massimo ^[2]; Banks, Lawrence ^[1]

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1. International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste (Italy)
2. Infections and Cancer Biology Group, International Agency for Research on Cancer - World Health Organization, 150 Cours Albert Thomas, 69372 Lyon (France)
3. Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow, Garscube Estate, Glasgow G61 1QH (United Kingdom)

It is well established that high-risk human papillomaviruses (HPVs) that infect mucosal epithelia are the causative agents of cervical cancer. In contrast, the association of cutaneo-tropic HPV types with the development of non-melanoma skin cancer (NMSC) is less well defined. In this study, we have analysed the in vitro transforming potential of various cutaneous HPV types. Using oncogene cooperation assays with activated ras, we have shown that diverse cutaneous types, including 12, 14, 15, 24, 36 and 49, have significant transforming potential. Interestingly, most of this activity appears to be encoded by the E6 gene product. In contrast, the common HPV-10 exhibits no significant transforming potential in these assays. This difference may be a reflection of different patterns of cellular localization, with transforming E6s being nuclear and non-transforming being cytoplasmic. These results provide molecular support for a role of these viruses in the development of certain human malignancies.

• OSTI ID: 21078022
• Journal Information: Virology, Vol. 371, Issue 2; Other Information: DOI: 10.1016/j.virol.2007.10.015; PII: S0042-6822(07)00659-9; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0042-6822
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CELL TRANSFORMATIONS
HEALTH HAZARDS
IN VITRO
MELANOMAS
ONCOGENES
VIRUSES