Universal Survival Curve and Single Fraction Equivalent Dose: Useful Tools in Understanding Potency of Ablative Radiotherapy

Park, Clint; Papiez, Lech; Shichuan, Zhang; Story, Michael

doi:10.1016/j.ijrobp.2007.10.059

Title: Universal Survival Curve and Single Fraction Equivalent Dose: Useful Tools in Understanding Potency of Ablative Radiotherapy

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Abstract

Purpose: Overprediction of the potency and toxicity of high-dose ablative radiotherapy such as stereotactic body radiotherapy (SBRT) by the linear quadratic (LQ) model led to many clinicians' hesitating to adopt this efficacious and well-tolerated therapeutic option. The aim of this study was to offer an alternative method of analyzing the effect of SBRT by constructing a universal survival curve (USC) that provides superior approximation of the experimentally measured survival curves in the ablative, high-dose range without losing the strengths of the LQ model around the shoulder. Methods and Materials: The USC was constructed by hybridizing two classic radiobiologic models: the LQ model and the multitarget model. We have assumed that the LQ model gives a good description for conventionally fractionated radiotherapy (CFRT) for the dose to the shoulder. For ablative doses beyond the shoulder, the survival curve is better described as a straight line as predicted by the multitarget model. The USC smoothly interpolates from a parabola predicted by the LQ model to the terminal asymptote of the multitarget model in the high-dose region. From the USC, we derived two equivalence functions, the biologically effective dose and the single fraction equivalent dose for both CFRT and SBRT. Results: The validitymore »« less

Authors:

Park, Clint; Papiez, Lech; Shichuan, Zhang; Story, Michael ^[1]

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX (United States)

Publication Date:: Sat Mar 01 00:00:00 EST 2008

OSTI Identifier:: 21039799

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 70; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2007.10.059; PII: S0360-3016(07)04460-4; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; APPROXIMATIONS; CARCINOMAS; DOSE EQUIVALENTS; FRACTIONATED IRRADIATION; LUNGS; RADIATION DOSES; RADIOTHERAPY; SURVIVAL CURVES; TOXICITY

Citation Formats


                    Park, Clint, Papiez, Lech, Shichuan, Zhang, Story, Michael, and Timmerman, Robert D. Universal Survival Curve and Single Fraction Equivalent Dose: Useful Tools in Understanding Potency of Ablative Radiotherapy.  United States: N. p., 2008. 
        Web.  doi:10.1016/j.ijrobp.2007.10.059.

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                    Park, Clint, Papiez, Lech, Shichuan, Zhang, Story, Michael, & Timmerman, Robert D. Universal Survival Curve and Single Fraction Equivalent Dose: Useful Tools in Understanding Potency of Ablative Radiotherapy.  United States.  https://doi.org/10.1016/j.ijrobp.2007.10.059

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                    Park, Clint, Papiez, Lech, Shichuan, Zhang, Story, Michael, and Timmerman, Robert D. 2008.  
        "Universal Survival Curve and Single Fraction Equivalent Dose: Useful Tools in Understanding Potency of Ablative Radiotherapy".  United States.  https://doi.org/10.1016/j.ijrobp.2007.10.059.

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@article{osti_21039799,

  title        = {Universal Survival Curve and Single Fraction Equivalent Dose: Useful Tools in Understanding Potency of Ablative Radiotherapy},

  author       = {Park, Clint and Papiez, Lech and Shichuan, Zhang and Story, Michael and Timmerman, Robert D.},

  abstractNote = {Purpose: Overprediction of the potency and toxicity of high-dose ablative radiotherapy such as stereotactic body radiotherapy (SBRT) by the linear quadratic (LQ) model led to many clinicians' hesitating to adopt this efficacious and well-tolerated therapeutic option. The aim of this study was to offer an alternative method of analyzing the effect of SBRT by constructing a universal survival curve (USC) that provides superior approximation of the experimentally measured survival curves in the ablative, high-dose range without losing the strengths of the LQ model around the shoulder. Methods and Materials: The USC was constructed by hybridizing two classic radiobiologic models: the LQ model and the multitarget model. We have assumed that the LQ model gives a good description for conventionally fractionated radiotherapy (CFRT) for the dose to the shoulder. For ablative doses beyond the shoulder, the survival curve is better described as a straight line as predicted by the multitarget model. The USC smoothly interpolates from a parabola predicted by the LQ model to the terminal asymptote of the multitarget model in the high-dose region. From the USC, we derived two equivalence functions, the biologically effective dose and the single fraction equivalent dose for both CFRT and SBRT. Results: The validity of the USC was tested by using previously published parameters of the LQ and multitarget models for non-small-cell lung cancer cell lines. A comparison of the goodness-of-fit of the LQ and USC models was made to a high-dose survival curve of the H460 non-small-cell lung cancer cell line. Conclusion: The USC can be used to compare the dose fractionation schemes of both CFRT and SBRT. The USC provides an empirically and a clinically well-justified rationale for SBRT while preserving the strengths of the LQ model for CFRT.},

  doi          = {10.1016/j.ijrobp.2007.10.059},

  url          = {https://www.osti.gov/biblio/21039799},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 3,

  volume       = 70,

  place        = {United States},

  year         = {Sat Mar 01 00:00:00 EST 2008},

  month        = {Sat Mar 01 00:00:00 EST 2008}

}

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