Randomized Comparison of Dry Dressings Versus Hydrogel in Management of Radiation-Induced Moist Desquamation
- Napier University, Faculty of Life Sciences, Edinburgh (United Kingdom)
- University of Dundee School of Nursing and Midwifery, Dundee (United Kingdom)
- Department of Surgery and Molecular Oncology, Ninewells Hospital and University of Dundee Medical School, Dundee (United Kingdom)
- University of St. Andrew's Faculty of Medicine, St. Andrews Fife (United Kingdom)
Purpose: We present the results of a randomized controlled clinical trial that evaluated the effect of a hydrogel or dry dressing on the time to healing of moist desquamation after radiotherapy to the head-and-neck, breast, or anorectal areas. Methods and Materials: A total of 357 patients were randomized before radiotherapy to receive simple dry dressings (Tricotex) or a hydrogel (Intrasite), with Tricotex as a secondary dressing. Patients were instructed to use their dressings from the onset of moist desquamation, if it occurred. Results: Of the 357 patients, 100 (28%) developed moist desquamation. The time to healing was significantly prolonged (hazard ratio, 0.64; 95% confidence interval, 0.42-0.99), in patients assigned to gel dressings. No evidence was found that gel dressings had a significant impact on subjectively reported skin symptoms. Conclusion: The results of this study have not supported the routine use of hydrogels in the care of patients with moist desquamation and suggests that the healing times are prolonged, without any improvement in patient comfort.
- OSTI ID:
- 20951717
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 68, Issue 3; Other Information: DOI: 10.1016/j.ijrobp.2006.12.049; PII: S0360-3016(07)00059-4; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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