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Title: Intermittent androgen ablation in patients with biochemical failure after pelvic radiotherapy for localized prostate cancer

Purpose: To assess the efficacy of intermittent androgen ablation (IAA) in patients with biochemical failure after radiotherapy for prostate cancer. Methods and Materials: Thirty-nine patients received a luteinizing hormone-releasing hormone analog every 2 months for a total of 4 doses. IAA was then discontinued if serum prostate-specific antigen (PSA) fell to a normal level with a castrate level of testosterone. Therapy was restarted when the serum PSA level reached {>=}10 ng/mL and was discontinued if hormone resistance or unacceptable toxicity occurred. Results: Median PSA was 9.1 ng/mL at the time of first IAA. The median time between the first and the second cycles was 20.1 months, decreasing to 15.5 months between the third and fourth cycles. Two patients discontinued the treatment because of severe hot flushes. Four patients developed hormone resistance. With a median follow-up of 56.4 months, 5-year survival is 92.3%. Three patients died of unrelated causes. The incidence of distant metastasis is 6.8%. Conclusions: The use of IAA seems to be a safe and effective treatment for patients with biochemical failure post radiotherapy and no evidence of metastatic disease. The use of IAA limits hormone-related side effects and health care costs without an apparent increase in the riskmore » for the development of metastatic disease.« less
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [3] ;  [1] ;  [1] ;  [1] ;  [1] ;  [1]
  1. Department of Oncology, Division of Radiation Oncology, McGill University, Montreal, Quebec (Canada)
  2. Department of Oncology, Division of Radiation Oncology, McGill University, Montreal, Quebec (Canada). E-mail: luis.souhami@muhc.mcgill.ca
  3. Department of Medicine, McGill University, Montreal, Quebec (Canada)
  4. Department of Urology, McGill University, Montreal, Quebec (Canada)
Publication Date:
OSTI Identifier:
20793354
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2005.08.034; PII: S0360-3016(05)02579-4; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABLATION; CARCINOMAS; FAILURES; LIBERINS; LUTEINIZING HORMONE; METASTASES; PATIENTS; PROSTATE; RADIOTHERAPY; SIDE EFFECTS; TESTOSTERONE; TOXICITY