Mode of action of poly(vinylpyridine-N-oxide) in preventing silicosis: Effective scavenging of carbonate anion radical
Journal Article
·
· Chemical Research in Toxicology
- Hebrew University of Jerusalem, Jerusalem (Israel). Dept. of Physical Chemistry
Inhalation of quartz crystallites causes silicosis, a devastating lung disease afflicting miners, particularly coal and stone workers. Poly(vinylpyridine-N-oxide)s (PVPNOs) have been applied in the prevention and treatment of silicosis, but their mode of action has been obscure. Here, we show that PVPNOs do not react with peroxynitrite but scavenge exceptionally rapidly carbonate radicals, which are produced in the decomposition of ONOO- in bicarbonate solutions.
- OSTI ID:
- 20712267
- Journal Information:
- Chemical Research in Toxicology, Vol. 19, Issue 1; ISSN 0893-228X
- Country of Publication:
- United States
- Language:
- English
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