Statins and transcriptional regulation: The FXR connection

Journal Article · Fri Aug 26 00:00:00 EDT 2005 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2005.06.129· OSTI ID:20710934

Habeos, Ioannis ^[1]; Ziros, Panos G ^[1]; Psyrogiannis, Agathoklis ^[2]; Vagenakis, Apostolos G ^[2]; Papavassiliou, Athanasios G ^[1]

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1. Department of Biochemistry, School of Medicine, University of Patras, 26110 Patras (Greece)
2. Department of Internal Medicine, School of Medicine, University of Patras, 26500 Patras (Greece)

Farnesoid X receptor (FXR) is a nuclear receptor involved in lipoprotein as well as glucose metabolism. Statins are widely used hypolipidemic agents with many pleiotropic actions. It is known that statins affect other nuclear hormone receptors, but no reports are available on the effect of these drugs on FXR. Employing an animal model (Syrian hamsters), we hereby present evidence to demonstrate that Simvastatin, a broadly prescribed statin, decreases the expression of FXR at both the RNA and protein levels and down-regulates its DNA-binding activity. This novel property may have important implications on the mode statins influence on lipoprotein and carbohydrate homeostasis in the organism.

• OSTI ID: 20710934
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 334, Issue 2; Other Information: DOI: 10.1016/j.bbrc.2005.06.129; PII: S0006-291X(05)01372-0; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
DNA
DRUGS
GENE REGULATION
GENES
GLUCOSE
HAMSTERS
HOMEOSTASIS
HORMONES
LIPOPROTEINS
METABOLISM
RECEPTORS
RNA