Approaches to Manufacturing Alpha Emitters For Radioimmunotherapeutic Drugs
- MedActinium, Inc., 313 Woodland Trace Dr., Knoxville, TN, 37922 (United States)
- University of Missouri, Columbia, Missouri, 65211 (United States)
- PG Research Foundation, Inc., 8205 South Cass Ave., Darien, IL, 60561 (United States)
Several alpha emitting isotopes have been proposed for radioimmunotherapy. To produce these nuclides reliably and in quantities needed, unique manufacturing approaches will be required. This paper describes the approaches that are being developed for the manufacture of 225Actinium (225 Ac) that decays to 213Bismuth (213 Bi) and the commercial manufacturing approaches. Oak Ridge National Laboratory (ORNL) currently supplies the actinium used for research and medical use. Today the ORNL 233U stockpiles only provide sufficient material for research quantities of 213 Bi. At the Institute for Transuranium Elements (ITU), in Karlsruhe, researchers have also developed a method of irradiating radium-226 with protons in a cyclotron to produce actinium- 225 through the reaction 226Ra (p, 2n) 225Ac. Researchers from the Missouri University (MU), the Missouri University Research Reactor (MURR), MedActinium, Inc. and Los Alamos National Laboratory (LANL) are working on a collaborative effort to benchmark and optimize the production of 213Bi via neutron bombardment of 226Ra. MedActinium, Inc., in collaboration with commercial and institutional investigators at PG Research Foundation (PGRF) and Memorial Sloan Kettering Cancer Center (MSKCC), is developing commercial approaches to manufacturing these unique radioimmunotherapeutic drugs.
- OSTI ID:
- 20632546
- Journal Information:
- AIP Conference Proceedings, Vol. 680, Issue 1; Conference: 17. international conference on the application of accelerators in research and industry, Denton, TX (United States), 12-16 Nov 2002; Other Information: DOI: 10.1063/1.1619908; (c) 2003 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Production of Thorium-229 at the ORNL High Flux Isotope Reactor
Large scale accelerator production of 225Ac: Effective cross sections for 78–192 MeV protons incident on 232Th targets