Ionizable calixarene-crown ethers with high selectivity for radium over light alkaline earth metal ions
{alpha} particle emitters are of increasing interest as the radionuclide attached to monoclonal antibodies of other targeting mechanisms for applications in cell-directed therapy of cancer. {alpha} particles are more effective than {beta}{sup {minus}} particles for cell-killing and promise a more effective treatment of cancer than other forms of radiation. This is because {alpha} particles have high initial energy (4--8 MeV), short path lengths (40--80 {micro}m, or several cell diameters), and consequently greater energy dissipation per unit length. Cell-directed immunotherapy can help improve irradiation of tumor cells while sparing normal tissues. The success of this approach will require effective chemistry for attaching the radionuclide to the antibody. Therefore, a concerted effort has been directed toward the design of chelating agents capable of holding the desired {alpha}-emitting radionuclide, both selectively and with high stability, to the antibody.
- Research Organization:
- Univ. of Idaho, Moscow, ID (US)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 20003198
- Journal Information:
- Inorganic Chemistry, Vol. 38, Issue 23; Other Information: PBD: 15 Nov 1999
- Country of Publication:
- United States
- Language:
- English
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