Structure of human type-I interferon gene cluster determined from a YAC clone contig

Journal Article · Mon Aug 01 00:00:00 EDT 1994 · Genomics

DOI:https://doi.org/10.1006/geno.1994.1427· OSTI ID:186025

Diaz, M O; Pomykala, H M; Bohlander, S K ^[1]

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1. Univ. of Chicago, IL (United States); and others

A map of the type-I interferon gene cluster located on the short arm of human chromosome 9 (9p) has been constructed using a contig of YAC clones. This map contains 26 interferon (IFN) genes and pseudogenes, and it accounts for all, except one, of the IFN sequences previously reported by other authors, plus a new IFNW pseudogene. The most distal gene on 9p is IFNB, and the most proximal one is IFNWP19. The direction of transcription for the 20 most distal IFN sequences is toward the telomere and for the 6 most proximal sequences, toward the centromere. Several regions of the cluster show evidence of ancestral duplication events. Some of these events may be explained by unequal crossing over between adjacent tandem genes. The location of several breakpoints within the cluster, from deletions associated with leukemias and gliomas, was also determined. 41 refs., 5 figs., 2 tabs.

• OSTI ID: 186025
• Journal Information: Genomics, Vol. 22, Issue 3; Other Information: PBD: Aug 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
99 MATHEMATICS
COMPUTERS
INFORMATION SCIENCE
MANAGEMENT
LAW
MISCELLANEOUS
GENES
GENETIC MAPPING
STRUCTURE-ACTIVITY RELATIONSHIPS
TRANSCRIPTION
BIOLOGICAL EVOLUTION
STANDARDIZED TERMINOLOGY
HUMAN CHROMOSOME 9
CROSSING-OVER
CHROMOSOME BREAKAGE
INTERFERON
YEASTS
CONTIGS
DNA-CLONING
DNA SEQUENCING
TELOMERES
CENTROMERES
LEUKEMIA
GLIOMAS
DNA HYBRIDIZATION
PROBES
NUCLEOTIDES
POLYMERASE CHAIN REACTION