Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?

Metz, Thomas O.; Baker, Erin S.; Schymanski, Emma L.; Renslow, Ryan S.; Thomas, Dennis G.; Causon, Tim J.; Webb, Ian K.; Hann, Stephan; Smith, Richard D.; Teeguarden, Justin G.

doi:10.4155/bio-2016-0244

Title: Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?

Journal Article · Tue Dec 06 00:00:00 EST 2016 · Bioanalysis

DOI:https://doi.org/10.4155/bio-2016-0244· OSTI ID:1342290

Metz, Thomas O. ^[1]; Baker, Erin S. ^[1]; Schymanski, Emma L. ^[2]; Renslow, Ryan S. ^[1]; Thomas, Dennis G. ^[1]; Causon, Tim J. ^[3]; Webb, Ian K. ^[1]; Hann, Stephan ^[3]; Smith, Richard D. ^[1]; Teeguarden, Justin G. ^[4]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Swiss Federal Institute of Aquatic Science & Technology, Dubendorf (Switzerland)
Univ. of Natural Resources & Life Sciences (BOKU Vienna), Vienna (Austria)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Oregon State Univ., Corvallis, OR (United States)

Here, measuring the exposome remains a challenge due to the range and number of anthropogenic molecules that are encountered in our daily lives, as well as the complex systemic responses to these exposures. One option for improving the coverage, dynamic range and throughput of measurements is to incorporate ion mobility spectrometry (IMS) into current mass spectrometry (MS)-based analytical methods. In this perspective, we briefly review the state-of-the-art in measuring the exposome, and discuss the potential use for IMS-MS and the physico-chemical property of collisional cross section in both exposure assessment and molecular identification.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1342290

Report Number(s):: PNNL-SA-121158; 48246

Journal Information:: Bioanalysis, Vol. 9, Issue 1; ISSN 1757-6180

Publisher:: Future Science GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 52 works

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