Links between persistent DNA damage, genome instability, and aging
- Emory Univ., Atlanta, GA (United States). Dept. of Radiation Oncology
The goal of this study was to examine long-term effects of low-dose radiation exposure. One of the hypotheses was that radiation exposure would accelerate the normal aging process. The study was jointly funded by NASA and examined both low-LET radiation (γ-rays) and high-LET radiation (1000 MeV/nucleon 56Fe ions) at doses of 0.1 Gy and up. The work used the Japanese medaka fish (Oryzias latipes), as a vertebrate model organism that can be maintained in large numbers at low cost for lifetime studies. Like other small laboratory fish, Japanese medaka share many anatomical and histological characteristics with other vertebrates, and a variety of genetic and genomic resources are available. Some work also used the zebrafish (Danio rerio), another widely used laboratory model organism.
- Research Organization:
- Georgia Health Sciences Univ. Research Inst., Inc., Augusta, GA (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC)
- DOE Contract Number:
- SC0002343
- OSTI ID:
- 1332061
- Report Number(s):
- DOE-GHSURI-22955
- Country of Publication:
- United States
- Language:
- English
Similar Records
Quantifiable Biomarkers of Normal Aging in the Japanese Medaka Fish (Oryzias latipes)
Synergistic Effect of High Charge and Energy Particle Radiation and Chronological Age on Biomarkers of Oxidative Stress and Tissue Degeneration: A Ground-Based Study Using the Vertebrate Laboratory Model Organism Oryzias latipes