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Title: Proceedings of the second annual deep brain stimulation think tank: What's in the pipeline

Journal Article · · International Journal of Neuroscience
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  1. Univ. of Florida, Gainesville, FL (United States)
  2. Beth Israel Deaconess Medical Center, Boston, MA (United States)
  3. Stanford Univ., Stanford, CA (United States)
  4. Univ. of Utah, Salt Lake City, UT (United States)
  5. Vanderbilt Univ., Nashville, TN (United States)
  6. Sapiens Steering Brain Stimulation, Eindhoven (The Netherlands)
  7. Univ. of California, San Francisco, CA (United States)
  8. Emory Univ., Atlanta, GA (United States)
  9. Massachusetts General Hospital, Boston, MA (United States)
  10. Georgetown Univ. Medical Center, Washington, D.C. (United States)
  11. Mount Sinai Hospital, New York, NY (United States)
  12. Brown Univ., Providence, RI (United States)
  13. Neuropace Univ., Mountain View, CA (United States)
  14. St. Jude Medical, Sylmar, CA (United States)
  15. St. Jude Medical, Sunnyvale, CA (United States)
  16. Univ. of Toronto, Toronto, ON (Canada)
  17. National Institutes of Health, Bethesda, MD (United States)
  18. Univ. of Kansas Medical Center, Kansas City, KS (United States)
  19. Cleveland Clinic, Cleveland, OH (United States)
  20. Case Western Univ., Cleveland, OH (United States)
  21. Mayo Clinic, Rochester, MN (United States)
  22. Univ. of California San Francisco, San Francisco, CA (United States)
  23. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
  24. Barrow Neuromodulation Ltd., Toronto, ON (United States)
  25. Univ. of California, Los Angeles, CA (United States)
  26. Functional Neuromodulation Ltd., Toronto, ON (Canada)
  27. Columbia Univ., New York, NY (United States)
  28. Medtronic, Minneapolis, MN (United States)
  29. Boston Scientific Neuromodulation, Valencia, CA (United States)
  30. Barrow Neurological Institute, Phoenix, AZ (United States)
  31. Rush Univ. Medical Center, Chicago, IL (United States)
  32. Univ. of Alabama, Birmingham, AL (United States)
+ Show Author Affiliations

Here the proceedings of the 2nd Annual Deep Brain Stimulation Think Tank summarize the most contemporary clinical, electrophysiological, and computational work on DBS for the treatment of neurological and neuropsychiatric disease and represent the insights of a unique multidisciplinary ensemble of expert neurologists, neurosurgeons, neuropsychologists, psychiatrists, scientists, engineers and members of industry. Presentations and discussions covered a broad range of topics, including advocacy for DBS, improving clinical outcomes, innovations in computational models of DBS, understanding of the neurophysiology of Parkinson's disease (PD) and Tourette syndrome (TS) and evolving sensor and device technologies.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
OSTI ID:
1263587
Journal Information:
International Journal of Neuroscience, Vol. 125, Issue 7; ISSN 0020-7454
Publisher:
Taylor & FrancisCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 9 works
Citation information provided by
Web of Science

References (80)

Patient-specific analysis of the volume of tissue activated during deep brain stimulation journal January 2007
Assessing the non-motor symptoms of Parkinson's disease: MDS-UPDRS and NMS Scale journal April 2013
Neuropsychological changes following deep brain stimulation surgery for Parkinson's disease: comparisons of treatment at pallidal and subthalamic targets versus best medical therapy journal September 2014
Pathological synchronization in Parkinson's disease: networks, models and treatments journal July 2007
Human Motor Cortical Activity Is Selectively Phase-Entrained on Underlying Rhythms journal September 2012
The impact of bilateral subthalamic stimulation on non-motor symptoms of Parkinson’s disease journal September 2011
Multicenter study report: electrophysiological monitoring procedures for subthalamic deep brain stimulation surgery in Parkinson’s disease journal April 2010
Closed-Loop Deep Brain Stimulation Is Superior in Ameliorating Parkinsonism journal October 2011
Deep brain stimulation induces BOLD activation in motor and non-motor networks: An fMRI comparison study of STN and EN/GPi DBS in large animals journal November 2012
Brain penetration effects of microelectrodes and DBS leads in STN or GPi journal February 2009
Neurons in the globus pallidus do not show correlated activity in the normal monkey, but phase-locked oscillations appear in the MPTP model of parkinsonism journal October 1995
A neurochemical closed-loop controller for deep brain stimulation: toward individualized smart neuromodulation therapies journal June 2014
Deep brain stimulation as a new therapeutic approach in therapy-resistant mental disorders: ethical aspects of investigational treatment journal October 2009
Centromedian-Parafascicular Deep Brain Stimulation Induces Differential Functional Inhibition of the Motor, Associative, and Limbic Circuits in Large Animals journal December 2013
Comparison between subthalamic nucleus and globus pallidus internus stimulation for postural performance in Parkinson's disease journal April 2004
A translational platform for prototyping closed-loop neuromodulation systems journal January 2013
International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study: Nonmotor Symptoms and PD journal March 2006
Neural Synchrony in Brain Disorders: Relevance for Cognitive Dysfunctions and Pathophysiology journal October 2006
A Trial of Scheduled Deep Brain Stimulation for Tourette Syndrome: Moving Away From Continuous Deep Brain Stimulation Paradigms journal January 2013
Coordinated reset has sustained aftereffects in Parkinsonian monkeys journal November 2012
Swallowing and deep brain stimulation in Parkinson's disease: A systematic review journal September 2013
Translational Imperatives in Deep Brain Stimulation Research: Addressing Neuroethical Issues of Consequences and Continuity of Clinical Care journal January 2014
Stimulation of the subthalamic nucleus at an earlier disease stage of Parkinson's disease: Concept and standards of the EARLYSTIM-study journal January 2013
Effects of Perceived Treatment on Quality of Life and Medical Outcomesin a Double-blind Placebo Surgery Trial journal April 2004
A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease journal October 2008
Reversing cognitive–motor impairments in Parkinson’s disease patients using a computational modelling approach to deep brain stimulation programming journal January 2010
Deep brain stimulation in early stage Parkinson's disease: operative experience from a prospective randomised clinical trial journal September 2011
Increased Thalamic Gamma Band Activity Correlates with Symptom Relief following Deep Brain Stimulation in Humans with Tourette’s Syndrome journal September 2012
The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation journal January 2009
Deep brain stimulation in Parkinson’s disease: meta-analysis of randomized controlled trials journal February 2014
Bilateral symmetry and coherence of subthalamic nuclei beta band activity in Parkinson's disease journal January 2010
High frequency stimulation of the subthalamic nucleus evokes striatal dopamine release in a large animal model of human DBS neurosurgery journal May 2010
Confirmation of functional zones within the human subthalamic nucleus: Patterns of connectivity and sub-parcellation using diffusion weighted imaging journal March 2012
The Organization of Prefrontal-Subthalamic Inputs in Primates Provides an Anatomical Substrate for Both Functional Specificity and Integration: Implications for Basal Ganglia Models and Deep Brain Stimulation journal March 2013
Subthalamic nucleus-deep brain stimulation for early motor complications in Parkinson's disease-the EARLYSTIM trial: Early is not always better: STN-DBS for Early Motor Complications in PD journal September 2014
Inhibition of levodopa effects by internal pallidal stimulation journal July 1998
Microlesion Effect as a Predictor of the Effectiveness of Subthalamic Deep Brain Stimulation for Parkinson’s Disease journal January 2013
High frequency deep brain stimulation attenuates subthalamic and cortical rhythms in Parkinson's disease journal January 2012
Neurotransmitter release from high-frequency stimulation of the subthalamic nucleus journal September 2004
Tau the IRON MAN journal April 2013
Subthalamic Nucleus Versus Globus Pallidus Internus Deep Brain Stimulation: Translating the Rematch Into Clinical Practice journal April 2014
Short latency activation of cortex by clinically effective thalamic brain stimulation for tremor journal August 2012
Validation of connectivity-based thalamic segmentation with direct electrophysiologic recordings from human sensory thalamus journal February 2012
Motor and Nonmotor Symptom Follow-Up in Parkinsonian Patients after Deep Brain Stimulation of the Subthalamic Nucleus journal January 2007
Coupling between Beta and High-Frequency Activity in the Human Subthalamic Nucleus May Be a Pathophysiological Mechanism in Parkinson's Disease journal May 2010
Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease journal January 2013
Subthalamic deep brain stimulation effects on odor identification in Parkinson's disease journal March 2014
Evaluation of functional goal outcomes using the Canadian Occupational Performance Measure (COPM) following Deep Brain Stimulation (DBS) in childhood dystonia journal May 2014
Nucleus Accumbens Deep Brain Stimulation Results in Insula and Prefrontal Activation: A Large Animal fMRI Study journal February 2013
The Patient-Centered Outcomes Research Institute (PCORI) National Priorities for Research and Initial Research Agenda journal April 2012
Frequency-dependent functional neuromodulatory effects on the motor network by ventral lateral thalamic deep brain stimulation in swine journal January 2015
Responsive cortical stimulation for the treatment of epilepsy journal January 2008
Coordinate-Based Lead Location Does Not Predict Parkinson's Disease Deep Brain Stimulation Outcome journal April 2014
Physiological and pathological oscillatory networks in the human motor system journal January 2006
Uncovering the hidden placebo effect in deep-brain stimulation for Parkinson's disease journal March 2004
Short latency activation of cortex during clinically effective subthalamic deep brain stimulation for Parkinson's disease journal May 2012
Commentary for “Progressive ataxia associated with scarring skin lesions and vertical gaze palsy” journal April 2013
Theoretical Analysis of the Local Field Potential in Deep Brain Stimulation Applications journal March 2013
Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease journal March 2013
Patients’ expectations of deep brain stimulation, and subjective perceived outcome related to clinical measures in Parkinson's disease: a mixed-method approach journal May 2013
Barriers to investigator-initiated deep brain stimulation and device research journal March 2014
Another face of placebo: The lessebo effect in Parkinson disease: Meta-analyses journal March 2014
Network modulation following sham surgery in Parkinson’s disease journal July 2014
Deep brain stimulation in children: experience and technical pearls: Clinical article journal December 2011
Dopamine Dependency of Oscillations between Subthalamic Nucleus and Pallidum in Parkinson's Disease journal February 2001
Move to the rhythm: oscillations in the subthalamic nucleus–external globus pallidus network journal October 2002
Synchronized Neuronal Discharge in the Basal Ganglia of Parkinsonian Patients Is Limited to Oscillatory Activity journal April 2002
Beta-Coupled High-Frequency Activity and Beta-Locked Neuronal Spiking in the Subthalamic Nucleus of Parkinson's Disease journal September 2014
A closer look at unilateral versus bilateral deep brain stimulation: results of the National Institutes of Health COMPARE cohort: Clinical article journal December 2010
Is deep brain stimulation neuroprotective if applied early in the course of PD? journal July 2008
Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation journal May 2012
High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory   Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance journal June 2008
Multi-institutional evaluation of deep brain stimulation targeting using probabilistic connectivity-based thalamic segmentation: Clinical article journal November 2011
Subthalamic Nucleus Deep Brain Stimulation Induces Motor Network BOLD Activation: Use of a High Precision MRI Guided Stereotactic System for Nonhuman Primates journal July 2014
Measurements of RF heating during 3.0-T MRI of a pig implanted with deep brain stimulator journal June 2013
Comonitoring of adenosine and dopamine using the Wireless Instantaneous Neurotransmitter Concentration System: proof of principle: Laboratory investigation journal March 2010
Synchronisation in the beta frequency-band — The bad boy of parkinsonism or an innocent bystander? journal May 2009
Placebo: From belief to movement journal March 2014
Are Beta Phase-Coupled High-Frequency Oscillations and Beta Phase-Locked Spiking Two Sides of the Same Coin? journal February 2015
Subthalamic Nucleus Stimulation Increases Brain Derived Neurotrophic Factor in the Nigrostriatal System and Primary Motor Cortex journal January 2011

Cited By (1)

The Striatum and Subthalamic Nucleus as Independent and Collaborative Structures in Motor Control journal March 2016

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
electrophysiology
movement disorders
neuroethics
deep brain stimulation
neurotechnology