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Title: Engineering Paper-Based Sensors for Zika Virus

Journal Article · · Trends in Molecular Medicine
 [1];  [1];  [2]
  1. Sandia National Lab. (SNL-CA), Livermore, CA (United States)
  2. Univ. of California, Davis, CA (United States). California Natiional Primate Research Center

The emergence of Zika virus in Latin America has created an urgent need for new, simple yet sensitive diagnostic tests. We highlight recent work using paper-based sensors coupled with CRISPR/Cas9 to detect Zika RNA, as a new approach to rapid development and deployment of field-ready diagnostics for emerging infectious diseases.

Research Organization:
Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA)
Grant/Contract Number:
AC04-94AL85000
OSTI ID:
1259488
Alternate ID(s):
OSTI ID: 1435397
Report Number(s):
SAND-2016-4594J; 640221
Journal Information:
Trends in Molecular Medicine, Vol. 22, Issue 7; ISSN 1471-4914
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 23 works
Citation information provided by
Web of Science

References (8)

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Isothermal nucleic acid amplification technologies for point-of-care diagnostics: a critical review journal January 2012
Quenching of Unincorporated Amplification Signal Reporters in Reverse-Transcription Loop-Mediated Isothermal Amplification Enabling Bright, Single-Step, Closed-Tube, and Multiplexed Detection of RNA Viruses journal March 2016
Development and deployment of a rapid recombinase polymerase amplification Ebola virus detection assay in Guinea in 2015 journal November 2015
Zika Virus journal March 2016

Cited By (37)

The applications of CRISPR/Cas system in molecular detection journal October 2018
Detection of chikungunya virus‐specific IgM on laser‐cut paper‐based device using pseudo‐particles as capture antigen journal February 2019
Field-Effect Biosensors for On-Site Detection: Recent Advances and Promising Targets journal September 2017
Validation of use of the miniPCR thermocycler for Ebola and Zika virus detection journal May 2019
Simpler, Faster, and Sensitive Zika Virus Assay Using Smartphone Detection of Loop-mediated Isothermal Amplification on Paper Microfluidic Chips journal August 2018
Loop-Mediated Isothermal Amplification (LAMP) for the Diagnosis of Zika Virus: A Review journal December 2019
A sensitive electrochemical immunosensor for label-free detection of Zika-virus protein journal June 2018
Synthetic Biology Enables Programmable Cell‐Based Biosensors journal January 2020
Computing with biological switches and clocks journal June 2018
In vitro multi-enzymatic cascades using recombinant lysates of E. coli: an emerging biocatalysis platform journal January 2020
Precise and Programmable Detection of Mutations Using Ultraspecific Riboregulators journal October 2020
Cell-free microcompartmentalised transcription–translation for the prototyping of synthetic communication networks journal August 2019
Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products journal June 2018
Synergistic and non-specific nucleic acid production by T7 RNA polymerase and Bsu DNA polymerase catalyzed by single-stranded polynucleotides journal June 2018
Blossom of CRISPR technologies and applications in disease treatment journal December 2018
Methods to reduce variability in E. Coli-based cell-free protein expression experiments journal December 2019
Long-Term Stability Monitoring of Printed Proteins on Paper-Based Membranes journal August 2019
Complex cellular logic computation using ribocomputing devices journal July 2017
Orthogonal regulation of DNA nanostructure self-assembly and disassembly using antibodies journal December 2019
Rapid, Affordable and Portable Medium-Throughput Molecular Device for Zika Virus journal December 2016
Rapid acquisition and model-based analysis of cell-free transcription–translation reactions from nonmodel bacteria journal April 2018
Achieving large dynamic range control of gene expression with a compact RNA transcription–translation regulator journal April 2017
Addressable configurations of DNA nanostructures for rewritable memory journal August 2017
High-density functional-RNA arrays as a versatile platform for studying RNA-based interactions journal May 2018
Strategies for in vitro engineering of the translation machinery journal November 2019
Low-cost detection of norovirus using paper-based cell-free systems and synbody-based viral enrichment journal January 2018
Microbially derived biosensors for diagnosis, monitoring and epidemiology journal August 2017
A modular yeast biosensor for low-cost point-of-care pathogen detection journal June 2017
BioBits™ Explorer: A modular synthetic biology education kit journal August 2018
BioBits™ Bright: A fluorescent synthetic biology education kit journal August 2018
Point-of-care biomarker quantification enabled by sample-specific calibration journal September 2019
Rapid colorimetric detection of Zika virus from serum and urine specimens by reverse transcription loop-mediated isothermal amplification (RT-LAMP) journal September 2017
Computer‐aided biochemical programming of synthetic microreactors as diagnostic devices journal June 2018
New Paradigms for Virus Detection, Surveillance and Control of Zika Virus Vectors in the Settings of Southeast Asia journal September 2016
An Alternative Medical Diagnosis Method: Biosensors for Virus Detection journal May 2019
A Paper-Based Device for Performing Loop-Mediated Isothermal Amplification with Real-Time Simultaneous Detection of Multiple DNA Targets journal January 2017
Development of a novel peptide aptamer-based immunoassay to detect Zika virus in serum and urine journal January 2018

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