Nanoporous Gold as a Neural Interface Coating: Effects of Topography, Surface Chemistry, and Feature Size

Chapman, Christopher A.  R.; Chen, Hao; Stamou, Marianna; Biener, Juergen; Biener, Monika M.; Lein, Pamela J.; Seker, Erkin

doi:10.1021/acsami.5b00410

Title: Nanoporous Gold as a Neural Interface Coating: Effects of Topography, Surface Chemistry, and Feature Size

Journal Article · Mon Feb 23 00:00:00 EST 2015 · ACS Applied Materials and Interfaces

DOI:https://doi.org/10.1021/acsami.5b00410· OSTI ID:1254148

Chapman, Christopher A. R. ^[1]; Chen, Hao ^[2]; Stamou, Marianna ^[2]; Biener, Juergen ^[3]; Biener, Monika M. ^[3]; Lein, Pamela J. ^[2]; Seker, Erkin ^[4]

Univ. of California, Davis, CA (United States). Dept. of Biomedical Engineering
Univ. of California, Davis, CA (United States). Dept. of Molecular Biosciences
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Univ. of California, Davis, CA (United States). Dept. of Electrical and Computer Engineering

We report that designing neural interfaces that maintain close physical coupling of neurons to an electrode surface remains a major challenge for both implantable and in vitro neural recording electrode arrays. Typically, low-impedance nanostructured electrode coatings rely on chemical cues from pharmaceuticals or surface-immobilized peptides to suppress glial scar tissue formation over the electrode surface (astrogliosis), which is an obstacle to reliable neuron–electrode coupling. Nanoporous gold (np-Au), produced by an alloy corrosion process, is a promising candidate to reduce astrogliosis solely through topography by taking advantage of its tunable length scale. In the present in vitro study on np-Au’s interaction with cortical neuron–glia co-cultures, we demonstrate that the nanostructure of np-Au achieves close physical coupling of neurons by maintaining a high neuron-to-astrocyte surface coverage ratio. Atomic layer deposition-based surface modification was employed to decouple the effect of morphology from surface chemistry. Additionally, length scale effects were systematically studied by controlling the characteristic feature size of np-Au through variations in the dealloying conditions. In conclusion, our results show that np-Au nanotopography, not surface chemistry, reduces astrocyte surface coverage while maintaining high neuronal coverage and may enhance neuron–electrode coupling through nanostructure-mediated suppression of scar tissue formation.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); Univ. of California, Davis, CA (United States)

Sponsoring Organization:: USDOE

Contributing Organization:: Univ. of California, Davis, CA (United States)

Grant/Contract Number:: AC52-07NA27344; 12-LR- 237197; DGE-1148897; T32-GM008799; U54 NS079202

OSTI ID:: 1254148

Journal Information:: ACS Applied Materials and Interfaces, Vol. 7, Issue 13; ISSN 1944-8244

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 105 works

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Title: Nanoporous Gold as a Neural Interface Coating: Effects of Topography, Surface Chemistry, and Feature Size

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