Cross-sections for (p,x) reactions on natural chromium for the production of 52,52m,54Mn radioisotopes

Wooten, A. Lake; Lewis, Benjamin C.; Lapi, Suzanne E.

doi:10.1016/j.apradiso.2014.12.001

Title: Cross-sections for (p,x) reactions on natural chromium for the production of ^52,52m,54Mn radioisotopes

Journal Article · Thu Dec 11 00:00:00 EST 2014 · Applied Radiation and Isotopes

DOI:https://doi.org/10.1016/j.apradiso.2014.12.001· OSTI ID:1344116

Wooten, A. Lake ^[1]; Lewis, Benjamin C. ^[2]; Lapi, Suzanne E. ^[1]

Washington Univ., St. Louis, MO (United States). Dept. of Biomedical Engineering; Washington Univ. School of Medicine, St. Louis, MO (United States). Mallinckrodt Inst. of Radiology
Washington Univ. School of Medicine, St. Louis, MO (United States). Mallinckrodt Inst. of Radiology

The production of positron-emitting isotopes of manganese is potentially important for developing contrast agents for dual-modality positron emission tomography and magnetic resonance (PET/MR) imaging, as well as for in vivo imaging of the biodistribution and toxicity of manganese. Furthermore, the decay properties of ⁵²Mn make it an excellent candidate for these applications, and it can easily be produced by bombardment of a chromium target with protons or deuterons from a low-energy biomedical cyclotron. There are several parameters essential to this mode of production—target thickness, beam energy, beam current, and bombardment time—depend heavily on the availability of reliable, reproducible cross-section data. Our paper contributes to the routine production of ^52gMn for biomedical research by contributing experimental cross-sections for natural chromium (^natCr) targets for the ^natCr(p,x)^52gMn reaction, as well as for the production of the radiocontaminants ^52m,⁵⁴Mn.

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Research Organization:: Washington Univ., St. Louis, MO (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH)

Grant/Contract Number:: NA0000979

OSTI ID:: 1344116

Alternate ID(s):: OSTI ID: 1250574

Journal Information:: Applied Radiation and Isotopes, Vol. 96, Issue C; ISSN 0969-8043

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 27 works

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Manganese in PET imaging: Opportunities and challenges Brandt, Marie; Cardinale, Jens; Rausch, Ivo Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 62, Issue 8 https://doi.org/10.1002/jlcr.3754	journal	June 2019
Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52 Wooten, A. Lake; Aweda, Tolulope A.; Lewis, Benjamin C. PLOS ONE, Vol. 12, Issue 3 https://doi.org/10.1371/journal.pone.0174351	journal	March 2017
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