Pre-transition effects mediate forces of assembly between transmembrane proteins

Katira, Shachi; Mandadapu, Kranthi K.; Vaikuntanathan, Suriyanarayanan; Smit, Berend; Chandler, David

doi:10.7554/eLife.13150

Title: Pre-transition effects mediate forces of assembly between transmembrane proteins

Journal Article · Wed Feb 24 00:00:00 EST 2016 · eLife

DOI:https://doi.org/10.7554/eLife.13150· OSTI ID:1247210

Katira, Shachi ^[1]; Mandadapu, Kranthi K. ^[2]; Vaikuntanathan, Suriyanarayanan ^[3]; Smit, Berend ^[4]; Chandler, David ^[1]

Univ. of California, Berkeley, CA (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States)
Univ. of Chicago, IL (United States)
Univ. of California, Berkeley, CA (United States); Ecole Polytechnique Federale Lausanne (Switzlerland)

We present a mechanism for a generic, powerful force of assembly and mobility for transmembrane proteins in lipid bilayers. This force is a pre-transition (or pre-melting) effect for the first-order transition between ordered and disordered phases in the membrane. Using large-scale molecular simulation, we show that a protein with hydrophobic thickness equal to that of the disordered phase embedded in an ordered bilayer stabilizes a microscopic order–disorder interface. The stiffness of that interface is finite. When two such proteins approach each other, they assemble because assembly reduces the net interfacial energy. Analogous to the hydrophobic effect, we refer to this phenomenon as the 'orderphobic effect'. The effect is mediated by proximity to the order–disorder phase transition and the size and hydrophobic mismatch of the protein. The strength and range of forces arising from this effect are significantly larger than those that could arise from membrane elasticity for the membranes considered.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231; FWP number SISGRKN

OSTI ID:: 1247210

Alternate ID(s):: OSTI ID: 1247211; OSTI ID: 1628845

Journal Information:: eLife, Journal Name: eLife Vol. 5; ISSN 2050-084X

Publisher:: eLife Sciences Publications, Ltd.Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 46 works

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