Crystal structure of N-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome

Czerwinski, Andrzej; Basava, Channa; Dauter, Miroslawa; Dauter, Zbigniew

doi:10.1107/S2056989015002091

Title: Crystal structure of N-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome

Journal Article · Sun Mar 01 00:00:00 EST 2015 · Acta Crystallographica. Section E, Crystallographic Communications

DOI:https://doi.org/10.1107/S2056989015002091· OSTI ID:1225201

Czerwinski, Andrzej ^[1]; Basava, Channa ^[1]; Dauter, Miroslawa ^[2]; Dauter, Zbigniew ^[2]

Peptides International, Inc., Louisville, KY (United States)
Argonne National Lab. (ANL), Argonne, IL (United States)

The title compound, C₂₀H₃₇N₃O₄, also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer. Thus, the crystal structure of ALLN, solved from synchrotron radiation diffraction data, revealed the molecules in extended conformation of the backbone and engaging all peptide N and O atoms in intermolecular hydrogen bonds forming an infinite antiparallel β-sheet.

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357; W-31-109-ENG-38

OSTI ID:: 1225201

Journal Information:: Acta Crystallographica. Section E, Crystallographic Communications, Vol. 71, Issue 3; ISSN 2056-9890

Publisher:: International Union of CrystallographyCopyright Statement

Country of Publication:: United States

Language:: English

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The Toxic Effect of ALLN on Primary Rat Retinal Neurons Li, Na; Shang, Lei; Wang, Shu-Chao Neurotoxicity Research, Vol. 30, Issue 3 https://doi.org/10.1007/s12640-016-9624-6	journal	May 2016