Proteomics of ovarian cancer: functional insights and clinical applications

Elzek, Mohamed A.; Rodland, Karin D.

doi:10.1007/s10555-014-9547-8

Title: Proteomics of ovarian cancer: functional insights and clinical applications

Journal Article · Wed Mar 04 00:00:00 EST 2015 · Cancer and Metastasis Reviews

DOI:https://doi.org/10.1007/s10555-014-9547-8· OSTI ID:1208724

Elzek, Mohamed A. ^[1]; Rodland, Karin D. ^[2]

Egybiotech for Research and Biotechnology, Alexandria (Egypt); Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division

In the past decade, there has been an increasing interest in applying proteomics to assist in understanding the pathogenesis of ovarian cancer, elucidating the mechanism of drug resistance, and in the development of biomarkers for early detection of ovarian cancer. Although ovarian cancer is a spectrum of different diseases, the strategies for diagnosis and treatment with surgery and adjuvant therapy are similar across ovarian cancer types, increasing the general applicability of discoveries made through proteomics research. While proteomic experiments face many difficulties which slow the pace of clinical applications, recent advances in proteomic technology contribute significantly to the identification of aberrant proteins and networks which can serve as targets for biomarker development and individualized therapies. This review provides a summary of the literature on proteomics’ contributions to ovarian cancer research and highlights the current issues, future directions, and challenges. In conclusion, we propose that protein-level characterization of primary lesion in ovarian cancer can decipher the mystery of this disease, improve diagnostic tools, and lead to more effective screening programs.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)

Sponsoring Organization:: USDOE; National Cancer Institute (NCI); National Inst.of Health (NIH)

Grant/Contract Number:: AC05-76RL01830; 5U24 CA160019-03; ACN12003-001-00000

OSTI ID:: 1208724

Report Number(s):: PNNL-SA-111055; 48666; 400412000

Journal Information:: Cancer and Metastasis Reviews, Vol. 34, Issue 1; ISSN 0167-7659

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 42 works

Citation information provided by
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References (134)

Mining the Ovarian Cancer Ascites Proteome for Potential Ovarian Cancer Biomarkers Kuk, Cynthia; Kulasingam, Vathany; Gunawardana, C. Geeth Molecular & Cellular Proteomics, Vol. 8, Issue 4 https://doi.org/10.1074/mcp.M800313-MCP200	journal	December 2008
Gene Expression Profiles Predict Early Relapse in Ovarian Cancer after Platinum-Paclitaxel Chemotherapy Hartmann, L. C. Clinical Cancer Research, Vol. 11, Issue 6 https://doi.org/10.1158/1078-0432.CCR-04-1673	journal	March 2005
Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor Pan, Bin-Tao; Johnstone, Rose M. Cell, Vol. 33, Issue 3 https://doi.org/10.1016/0092-8674(83)90040-5	journal	July 1983
Application of systems biology principles to protein biomarker discovery: Urinary exosomal proteome in renal transplantation Pisitkun, Trairak; Gandolfo, Maria T.; Das, Samarjit PROTEOMICS - Clinical Applications, Vol. 6, Issue 5-6 https://doi.org/10.1002/prca.201100108	journal	June 2012
Genomic Predictors of Outcome and Treatment Response in Breast Cancer Dunn, Lara; DeMichele, Angela Molecular Diagnosis & Therapy, Vol. 13, Issue 2 https://doi.org/10.1007/BF03256317	journal	April 2009
Proteomic analyses of serous and endometrioid epithelial ovarian cancers - Cases studies - Molecular insights of a possible histological etiology of serous ovarian cancer Longuespée, Rémi; Gagnon, Hugo; Boyon, Charlotte PROTEOMICS - Clinical Applications, Vol. 7, Issue 5-6 https://doi.org/10.1002/prca.201200079	journal	June 2013
Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) Menon, Usha; Gentry-Maharaj, Aleksandra; Hallett, Rachel The Lancet Oncology, Vol. 10, Issue 4 https://doi.org/10.1016/S1470-2045(09)70026-9	journal	April 2009
Therapeutic strategies in epithelial ovarian cancer Kim, Ayako; Ueda, Yutaka; Naka, Tetsuji Journal of Experimental & Clinical Cancer Research, Vol. 31, Issue 1 https://doi.org/10.1186/1756-9966-31-14	journal	January 2012
Label-Free LC-MSe in Tissue and Serum Reveals Protein Networks Underlying Differences between Benign and Malignant Serous Ovarian Tumors Wegdam, Wouter; Argmann, Carmen A.; Kramer, Gertjan PLoS ONE, Vol. 9, Issue 9 https://doi.org/10.1371/journal.pone.0108046	journal	September 2014
Proteomic Identification of Paclitaxel-Resistance Associated hnRNP A2 and GDI 2 Proteins in Human Ovarian Cancer Cells Lee, Dong Hyeon; Chung, Kwanghoe; Song, Ji-Ae Journal of Proteome Research, Vol. 9, Issue 11 https://doi.org/10.1021/pr100478u	journal	November 2010
Identification of Platinum-Resistance Associated Proteins through Proteomic Analysis of Human Ovarian Cancer Cells and Their Platinum-Resistant Sublines Yan, Xue-dong; Pan, Ling-ya; Yuan, Ye Journal of Proteome Research, Vol. 6, Issue 2 https://doi.org/10.1021/pr060402r	journal	February 2007
Historical perspective of peptidomics Schrader, Michael; Schulz-Knappe, Peter; Fricker, Lloyd D. EuPA Open Proteomics, Vol. 3 https://doi.org/10.1016/j.euprot.2014.02.014	journal	June 2014
Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present Bantscheff, Marcus; Lemeer, Simone; Savitski, Mikhail M. Analytical and Bioanalytical Chemistry, Vol. 404, Issue 4 https://doi.org/10.1007/s00216-012-6203-4	journal	July 2012
Identification and proteomic profiling of exosomes in human cerebrospinal fluid Street, Jonathan M.; Barran, Perdita E.; Mackay, C. Logan Journal of Translational Medicine, Vol. 10, Issue 1 https://doi.org/10.1186/1479-5876-10-5	journal	January 2012
Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells Safaei, R. Molecular Cancer Therapeutics, Vol. 4, Issue 10 https://doi.org/10.1158/1535-7163.MCT-05-0102	journal	October 2005
Proteomic analysis of post-translational modifications Mann, Matthias; Jensen, Ole N. Nature Biotechnology, Vol. 21, Issue 3 https://doi.org/10.1038/nbt0303-255	journal	March 2003
Genomic signatures to guide the use of chemotherapeutics Potti, Anil; Dressman, Holly K.; Bild, Andrea Nature Medicine, Vol. 12, Issue 11 https://doi.org/10.1038/nm1491	journal	October 2006
Investigation of the Ovarian and Prostate Cancer Peptidome for Candidate Early Detection Markers Using a Novel Nanoparticle Biomarker Capture Technology Fredolini, Claudia; Meani, Francesco; Luchini, Alessandra The AAPS Journal, Vol. 12, Issue 4 https://doi.org/10.1208/s12248-010-9211-3	journal	June 2010
THE CHRONOLOGY OF EARLY EPIC - (O.) Andersen, (D.T.T.) Haug (edd.) Relative Chronology in Early Greek Epic Poetry. Pp. xiv + 277, figs. Cambridge: Cambridge University Press, 2012. Cased, £60, US$99. ISBN: 978-0-521-19497-6. Hitch, Sarah The Classical Review, Vol. 64, Issue 1 https://doi.org/10.1017/S0009840X13002084	journal	March 2014
Ovarian cancer molecular pathology Longuespée, Rémi; Boyon, C.; Desmons, Annie Cancer and Metastasis Reviews, Vol. 31, Issue 3-4 https://doi.org/10.1007/s10555-012-9383-7	journal	June 2012
Comparative Proteomic Analysis of Paclitaxel Sensitive A2780 Epithelial Ovarian Cancer Cell Line and Its Resistant Counterpart A2780TC1 by 2D-DIGE: The Role of ERp57 Cicchillitti, Lucia; Di Michele, Michela; Urbani, Andrea Journal of Proteome Research, Vol. 8, Issue 4 https://doi.org/10.1021/pr800856b	journal	April 2009
Ovarian Carcinoma Subtypes Are Different Diseases: Implications for Biomarker Studies Köbel, Martin; Kalloger, Steve E.; Boyd, Niki PLoS Medicine, Vol. 5, Issue 12 https://doi.org/10.1371/journal.pmed.0050232	journal	December 2008
Effect of Screening on Ovarian Cancer Mortality: The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial Buys, Saundra S. JAMA, Vol. 305, Issue 22 https://doi.org/10.1001/jama.2011.766	journal	June 2011
A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation Wiegand, Kimberly C.; Hennessy, Bryan T.; Leung, Samuel BMC Cancer, Vol. 14, Issue 1 https://doi.org/10.1186/1471-2407-14-120	journal	February 2014
Prediction of optimal versus suboptimal cytoreduction of advanced-stage serous ovarian cancer with the use of microarrays Berchuck, Andrew; Iversen, Edwin S.; Lancaster, Johnathan M. American Journal of Obstetrics and Gynecology, Vol. 190, Issue 4 https://doi.org/10.1016/j.ajog.2004.02.005	journal	April 2004
Diverse Tumorigenic Pathways in Ovarian Serous Carcinoma Singer, Gad; Kurman, Robert J.; Chang, Hsueh-Wei The American Journal of Pathology, Vol. 160, Issue 4 https://doi.org/10.1016/S0002-9440(10)62549-7	journal	April 2002
Proteomics by Mass Spectrometry: Approaches, Advances, and Applications Yates, John R.; Ruse, Cristian I.; Nakorchevsky, Aleksey Annual Review of Biomedical Engineering, Vol. 11, Issue 1 https://doi.org/10.1146/annurev-bioeng-061008-124934	journal	August 2009
The dynamic range problem in the analysis of the plasma proteome Hortin, Glen L.; Sviridov, Denis Journal of Proteomics, Vol. 73, Issue 3 https://doi.org/10.1016/j.jprot.2009.07.001	journal	January 2010
Quantitative Proteomics Analysis Identifies Mitochondria as Therapeutic Targets of Multidrug-Resistance in Ovarian Cancer Chen, Xiulan; Wei, Shasha; Ma, Ying Theranostics, Vol. 4, Issue 12 https://doi.org/10.7150/thno.8502	journal	January 2014
Serum biomarker panels for the discrimination of benign from malignant cases in patients with an adnexal mass Nolen, Brian; Velikokhatnaya, Liudmila; Marrangoni, Adele Gynecologic Oncology, Vol. 117, Issue 3 https://doi.org/10.1016/j.ygyno.2010.02.005	journal	June 2010
Exosomes: an overview of biogenesis, composition and role in ovarian cancer Beach, Allison; Zhang, Huang-Ge; Ratajczak, Mariusz Z. Journal of Ovarian Research, Vol. 7, Issue 1 https://doi.org/10.1186/1757-2215-7-14	journal	January 2014
Toward improving the proteomic analysis of formalin-fixed, paraffin-embedded tissue Fowler, Carol B.; O’Leary, Timothy J.; Mason, Jeffrey T. Expert Review of Proteomics, Vol. 10, Issue 4 https://doi.org/10.1586/14789450.2013.820531	journal	August 2013
Proteomic analysis reflects different histologic subtypes of epithelial ovarian cancer Jia, Lin; Zhang, Hui; Qu, Xun Medical Hypotheses, Vol. 78, Issue 3 https://doi.org/10.1016/j.mehy.2011.11.017	journal	March 2012
A database of mass spectrometric assays for the yeast proteome Picotti, Paola; Lam, Henry; Campbell, David Nature Methods, Vol. 5, Issue 11 https://doi.org/10.1038/nmeth1108-913	journal	November 2008
Differential Exoprotease Activities Confer Tumor-Specific Serum Peptidome Patterns Zlotta, Alexandre R. European Urology, Vol. 49, Issue 4 https://doi.org/10.1016/j.eururo.2006.02.005	journal	April 2006
Human Epididymis Protein 4 (HE4) Is a Secreted Glycoprotein that Is Overexpressed by Serous and Endometrioid Ovarian Carcinomas Drapkin, Ronny; von Horsten, Hans Henning; Lin, Yafang Cancer Research, Vol. 65, Issue 6 https://doi.org/10.1158/0008-5472.CAN-04-3924	journal	March 2005
Potential tumor biomarkers identified in ovarian cyst fluid by quantitative proteomic analysis, iTRAQ Kristjansdottir, Björg; Levan, Kristina; Partheen, Karolina Clinical Proteomics, Vol. 10, Issue 1 https://doi.org/10.1186/1559-0275-10-4	journal	April 2013
Glycoproteomic identification of potential glycoprotein biomarkers in ovarian cancer proximal fluids Kuzmanov, Uros; Musrap, Natasha; Kosanam, Hari Clinical Chemistry and Laboratory Medicine, Vol. 51, Issue 7 https://doi.org/10.1515/cclm-2012-0642	journal	January 2013
CA125 surveillance increases optimal resectability at secondary cytoreductive surgery for recurrent epithelial ovarian cancer Fleming, Nicole D.; Cass, Ilana; Walsh, Christine S. Gynecologic Oncology, Vol. 121, Issue 2 https://doi.org/10.1016/j.ygyno.2011.01.014	journal	May 2011
Integrated Proteomic Analysis of Human Cancer Cells and Plasma from Tumor Bearing Mice for Ovarian Cancer Biomarker Discovery Pitteri, Sharon J.; JeBailey, Lellean; Faça, Vitor M. PLoS ONE, Vol. 4, Issue 11 https://doi.org/10.1371/journal.pone.0007916	journal	November 2009
Management Strategies for Recurrent Platinum-Resistant Ovarian Cancer Naumann, R. Wendel; Coleman, Robert L. Drugs, Vol. 71, Issue 11 https://doi.org/10.2165/11591720-000000000-00000	journal	January 2011
Prediction of optimal versus suboptimal cytoreduction of advanced-stage serious ovarian cancer with the use of microarrays The Women's Oncology Review, Vol. 4, Issue 3, p. 203-204 https://doi.org/10.3109/14733400412331312585	journal	September 2004
The Cell of Origin of Ovarian Epithelial Tumors and the Ovarian Surface Epithelium Dogma: Does the Emperor Have No Clothes? Dubeau, Louis Gynecologic Oncology, Vol. 72, Issue 3 https://doi.org/10.1006/gyno.1998.5275	journal	March 1999
HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the Risk of Ovarian Malignancy Algorithm Van Gorp, T.; Cadron, I.; Despierre, E. British Journal of Cancer, Vol. 104, Issue 5 https://doi.org/10.1038/sj.bjc.6606092	journal	February 2011
Origin and Pathogenesis of Pelvic (Ovarian, Tubal, and Primary Peritoneal) Serous Carcinoma Nik, Niloofar N.; Vang, Russell; Shih, Ie-Ming Annual Review of Pathology: Mechanisms of Disease, Vol. 9, Issue 1 https://doi.org/10.1146/annurev-pathol-020712-163949	journal	January 2014
Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics Tian, Yuan; Yao, Zhihao; Roden, Richard B. S. PROTEOMICS, Vol. 11, Issue 24 https://doi.org/10.1002/pmic.201000811	journal	November 2011
Prediction of optimal versus suboptimal cytoreduction of advanced-stage serious ovarian cancer with the use of microarrays Not Available, Not Available The Women's Oncology Review, Vol. 4, Issue 3 https://doi.org/10.1080/14733400412331312585	journal	September 2004
Mass spectrometry-based proteomics Aebersold, Ruedi; Mann, Matthias Nature, Vol. 422, Issue 6928 https://doi.org/10.1038/nature01511	journal	March 2003
Comprehensive Analysis of Conditioned Media from Ovarian Cancer Cell Lines Identifies Novel Candidate Markers of Epithelial Ovarian Cancer Gunawardana, C. Geeth; Kuk, Cynthia; Smith, Chris R. Journal of Proteome Research, Vol. 8, Issue 10 https://doi.org/10.1021/pr900411g	journal	October 2009
A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation Wiegand, Kimberly C.; Hennessy, Bryan T.; Leung, Samuel BioMed Central https://doi.org/10.14288/1.0223655	text	January 2014
A Proteome Resource of Ovarian Cancer Ascites: Integrated Proteomic and Bioinformatic Analyses To Identify Putative Biomarkers Gortzak-Uzan, Limor; Ignatchenko, Alex; Evangelou, Andreas I. Journal of Proteome Research, Vol. 7, Issue 1 https://doi.org/10.1021/pr0703223	journal	January 2008
The outcomes of ovarian cancer treatment are better when provided by gynecologic oncologists and in specialized hospitals: A systematic review Vernooij, Flora; Heintz, Peter; Witteveen, Els Gynecologic Oncology, Vol. 105, Issue 3 https://doi.org/10.1016/j.ygyno.2007.02.030	journal	June 2007
In-depth proteomic analyses of ovarian cancer cell line exosomes reveals differential enrichment of functional categories compared to the NCI 60 proteome Sinha, Ankit; Ignatchenko, Vladimir; Ignatchenko, Alex Biochemical and Biophysical Research Communications, Vol. 445, Issue 4 https://doi.org/10.1016/j.bbrc.2013.12.070	journal	March 2014
A Xenograft Mouse Model Coupled with In-depth Plasma Proteome Analysis Facilitates Identification of Novel Serum Biomarkers for Human Ovarian Cancer Tang, Hsin-Yao; Beer, Lynn A.; Chang-Wong, Tony Journal of Proteome Research, Vol. 11, Issue 2 https://doi.org/10.1021/pr200603h	journal	November 2011
Proteogenomic characterization of human colon and rectal cancer Zhang, Bing; Wang, Jing; Wang, Xiaojing Nature, Vol. 513, Issue 7518 https://doi.org/10.1038/nature13438	journal	July 2014
Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling Chairoungdua, Arthit; Smith, Danielle L.; Pochard, Pierre The Journal of Cell Biology, Vol. 190, Issue 6 https://doi.org/10.1083/jcb.201002049	journal	September 2010
Variation and genetic control of protein abundance in humans Wu, Linfeng; Candille, Sophie I.; Choi, Yoonha Nature, Vol. 499, Issue 7456 https://doi.org/10.1038/nature12223	journal	May 2013
Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence Blom, Nikolaj; Sicheritz-Pontén, Thomas; Gupta, Ramneek PROTEOMICS, Vol. 4, Issue 6 https://doi.org/10.1002/pmic.200300771	journal	June 2004
LC−MS/MS Analysis of Ovarian Cancer Metastasis-Related Proteins Using a Nude Mouse Model: 14-3-3 Zeta as a Candidate Biomarker He, Yifeng; Wu, Xin; Liu, Xiaohui Journal of Proteome Research, Vol. 9, Issue 12 https://doi.org/10.1021/pr100822v	journal	December 2010
Integrated genomic analyses of ovarian carcinoma Network, Atlas Research Nature, Vol. 474, Issue 7353, p. 609-615 https://doi.org/10.1038/nature10166	journal	June 2011
Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis Abbott, Karen L.; Lim, Jae-Min; Wells, Lance PROTEOMICS, Vol. 10, Issue 3 https://doi.org/10.1002/pmic.200900537	journal	December 2009
Proteomic analysis of microvesicles in human saliva by gel electrophoresis with liquid chromatography-mass spectrometry Xiao, Hua; Wong, David T. W. Analytica Chimica Acta, Vol. 723 https://doi.org/10.1016/j.aca.2012.02.018	journal	April 2012
Proteomic tracking of serum protein isoforms as screening biomarkers of ovarian cancer Ahmed, Nuzhat; Oliva, Karen T.; Barker, Gillian PROTEOMICS, Vol. 5, Issue 17 https://doi.org/10.1002/pmic.200401321	journal	October 2005
Lessons from BRCA: The Tubal Fimbria Emerges as an Origin for Pelvic Serous Cancer Crum, C. P.; Drapkin, R.; Kindelberger, D. Clinical Medicine & Research, Vol. 5, Issue 1 https://doi.org/10.3121/cmr.2007.702	journal	March 2007
PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies Lee, J-m.; Ledermann, J. A.; Kohn, E. C. Annals of Oncology, Vol. 25, Issue 1 https://doi.org/10.1093/annonc/mdt384	journal	January 2014
The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory Kurman, Robert J.; Shih, Ie-Ming The American Journal of Surgical Pathology, Vol. 34, Issue 3 https://doi.org/10.1097/PAS.0b013e3181cf3d79	journal	January 2010
Evaluating cell lines as tumour models by comparison of genomic profiles Domcke, Silvia; Sinha, Rileen; Levine, Douglas A. Nature Communications, Vol. 4, Issue 1 https://doi.org/10.1038/ncomms3126	journal	July 2013
A proteomic kinetic analysis of IGROV1 ovarian carcinoma cell line response to cisplatin treatment Le Moguen, Karen; Lincet, Hubert; Marcelo, Paulo PROTEOMICS, Vol. 7, Issue 22 https://doi.org/10.1002/pmic.200700231	journal	November 2007
Proteomic Analysis of Urinary Exosomes in Cardiovascular and Associated Kidney Diseases by Two-Dimensional Electrophoresis and LC–MS/MS Zubiri, Irene; Vivanco, Fernando; Alvarez-Llamas, Gloria Methods in Molecular Biology https://doi.org/10.1007/978-1-62703-405-0_16	book	January 2013
Integrated genomic analyses of ovarian carcinoma Charles, Perou, The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/hvp3-wg08	text	January 2011
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Farmer, Hannah; McCabe, Nuala; Lord, Christopher J. Nature, Vol. 434, Issue 7035 https://doi.org/10.1038/nature03445	journal	April 2005
Mitochondrial comparative proteomics of human ovarian cancer cells and their platinum-resistant sublines Dai, Zhiqin; Yin, Jie; He, Haojie PROTEOMICS, Vol. 10, Issue 21 https://doi.org/10.1002/pmic.200900685	journal	October 2010
A Novel, High-Throughput Workflow for Discovery and Identification of Serum Carrier Protein-Bound Peptide Biomarker Candidates in Ovarian Cancer Samples Lopez, Mary F.; Mikulskis, Alvydas; Kuzdzal, Scott Clinical Chemistry, Vol. 53, Issue 6 https://doi.org/10.1373/clinchem.2006.080721	journal	June 2007
Comparative Proteomics of Ovarian Epithelial Tumors An, Hee Jung; Kim, Dong Su; Park, Yong Kyu Journal of Proteome Research, Vol. 5, Issue 5 https://doi.org/10.1021/pr050461p	journal	May 2006
Characterization of serum biomarkers for detection of early stage ovarian cancer Kozak, Katherine R.; Su, Feng; Whitelegge, Julian P. PROTEOMICS, Vol. 5, Issue 17 https://doi.org/10.1002/pmic.200500093	journal	October 2005
Global quantification of mammalian gene expression control Schwanhäusser, Björn; Busse, Dorothea; Li, Na Nature, Vol. 473, Issue 7347 https://doi.org/10.1038/nature10098	journal	May 2011
In 2014, can we do better than CA125 in the early detection of ovarian cancer? Cohen, Joshua G. World Journal of Biological Chemistry, Vol. 5, Issue 3 https://doi.org/10.4331/wjbc.v5.i3.286	journal	January 2014
A randomized study of screening for ovarian cancer: a multicenter study in Japan Kobayashi, H.; Yamada, Y.; Sado, T. International Journal of Gynecologic Cancer, Vol. 18, Issue 3 https://doi.org/10.1111/j.1525-1438.2007.01035.x	journal	May 2008
Gene Expression Signature With Independent Prognostic Significance in Epithelial Ovarian Cancer Spentzos, Dimitrios; Levine, Douglas A.; Ramoni, Marco F. Journal of Clinical Oncology, Vol. 22, Issue 23 https://doi.org/10.1200/JCO.2004.04.070	journal	December 2004
Proteomic characterization of ovarian cancers identifying annexin-A4, phosphoserine aminotransferase, cellular retinoic acid-binding protein 2, and serpin B5 as histology-specific biomarkers Toyama, Atsuhiko; Suzuki, Atsushi; Shimada, Takashi Cancer Science, Vol. 103, Issue 4 https://doi.org/10.1111/j.1349-7006.2012.02224.x	journal	February 2012
Early Detection of Ovarian Cancer: Promise and Reality Bast, Jr., Robert C.; Urban, Nicole; Shridhar, Viji Cancer Treatment and Research https://doi.org/10.1007/978-1-4757-3587-1_3	book	January 2002
Intraepithelial Carcinoma of the Fimbria and Pelvic Serous Carcinoma: Evidence for a Causal Relationship Kindelberger, David W.; Lee, Yonghee; Miron, Alexander The American Journal of Surgical Pathology, Vol. 31, Issue 2 https://doi.org/10.1097/01.pas.0000213335.40358.47	journal	January 2007
Biomarker Failures Ioannidis, John PA Clinical Chemistry, Vol. 59, Issue 1 https://doi.org/10.1373/clinchem.2012.185801	journal	January 2013
Mitochondrial comparative proteomics of human ovarian cancer cells and their platinum-resistant sublines Dai, Zhiqin; Yin, Jie; He, Haojie PROTEOMICS - Clinical Applications, Vol. 5, Issue 3-4 https://doi.org/10.1002/prca.201190016	journal	March 2011
Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Menon, U.; Gentry-Maharaj, A.; Hallet, R. The Lancet Oncology, Vol. 10, Issue 4, p. 327-340 https://doi.org/10.3410/f.1160623.622001	journal	April 2009
Glycoproteomics of paclitaxel resistance in human epithelial ovarian cancer cell lines: Towards the identification of putative biomarkers Di Michele, Michela; Marcone, Simone; Cicchillitti, Lucia Journal of Proteomics, Vol. 73, Issue 5 https://doi.org/10.1016/j.jprot.2009.11.012	journal	March 2010
Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review Azmi, Asfar S.; Bao, Bin; Sarkar, Fazlul H. Cancer and Metastasis Reviews, Vol. 32, Issue 3-4 https://doi.org/10.1007/s10555-013-9441-9	journal	May 2013
Investigation of ovarian cancer associated sialylation changes in N-linked glycopeptides by quantitative proteomics Shetty, Vivekananda; Hafner, Julie; Shah, Punit Clinical Proteomics, Vol. 9, Issue 1 https://doi.org/10.1186/1559-0275-9-10	journal	January 2012
Serum S100A6 Concentration Predicts Peritoneal Tumor Burden in Mice with Epithelial Ovarian Cancer and Is Associated with Advanced Stage in Patients Wei, Bih-Rong; Hoover, Shelley B.; Ross, Mark M. PLoS ONE, Vol. 4, Issue 10 https://doi.org/10.1371/journal.pone.0007670	journal	October 2009
Gene-expression profiling in epithelial ovarian cancer Konstantinopoulos, Panagiotis A.; Spentzos, Dimitrios; Cannistra, Stephen A. Nature Clinical Practice Oncology, Vol. 5, Issue 10 https://doi.org/10.1038/ncponc1178	journal	July 2008
Molecular Cloning of the CA125 Ovarian Cancer Antigen: IDENTIFICATION AS A NEW MUCIN, MUC16 Yin, Beatrice W. T.; Lloyd, Kenneth O. Journal of Biological Chemistry, Vol. 276, Issue 29 https://doi.org/10.1074/jbc.M103554200	journal	May 2001
Ovarian cancer: strategies for overcoming resistance to chemotherapy Agarwal, Roshan; Kaye, Stan B. Nature Reviews Cancer, Vol. 3, Issue 7 https://doi.org/10.1038/nrc1123	journal	July 2003
Studies of the ‘hook’ effect in the one-step sandwich immunoassay Amarasiri Fernando, S.; Wilson, George S. Journal of Immunological Methods, Vol. 151, Issue 1-2 https://doi.org/10.1016/0022-1759(92)90104-2	journal	July 1992
Functional Proteomic Analysis of Advanced Serous Ovarian Cancer Using Reverse Phase Protein Array: TGF- Pathway Signaling Indicates Response to Primary Chemotherapy Carey, M. S.; Agarwal, R.; Gilks, B. Clinical Cancer Research, Vol. 16, Issue 10 https://doi.org/10.1158/1078-0432.CCR-09-2502	journal	May 2010
Exosomes with Immune Modulatory Features Are Present in Human Breast Milk Admyre, Charlotte; Johansson, Sara M.; Qazi, Khaleda Rahman The Journal of Immunology, Vol. 179, Issue 3 https://doi.org/10.4049/jimmunol.179.3.1969	journal	July 2007
HE4 in ovarian cancer Montagnana, M.; Danese, E.; Giudici, S. Advances in Clinical Chemistry https://doi.org/10.1016/B978-0-12-387042-1.00001-0	book	September 2011
Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm Kurman, Robert J.; Shih, Ie-Ming Human Pathology, Vol. 42, Issue 7 https://doi.org/10.1016/j.humpath.2011.03.003	journal	July 2011
A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass Moore, Richard G.; McMeekin, D. Scott; Brown, Amy K. Gynecologic Oncology, Vol. 112, Issue 1 https://doi.org/10.1016/j.ygyno.2008.08.031	journal	January 2009
Laser-capture microdissection Espina, Virginia; Wulfkuhle, Julia D.; Calvert, Valerie S. Nature Protocols, Vol. 1, Issue 2 https://doi.org/10.1038/nprot.2006.85	journal	June 2006
Quantification of β-Catenin Signaling Components in Colon Cancer Cell Lines, Tissue Sections, and Microdissected Tumor Cells using Reaction Monitoring Mass Spectrometry Chen, Yi; Gruidl, Mike; Remily-Wood, Elizabeth Journal of Proteome Research, Vol. 9, Issue 8 https://doi.org/10.1021/pr1005197	journal	August 2010
Phosphoproteomics in cancer Harsha, H. C.; Pandey, Akhilesh Molecular Oncology, Vol. 4, Issue 6 https://doi.org/10.1016/j.molonc.2010.09.004	journal	September 2010
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Beyond chemotherapy: targeted therapies in ovarian cancer Yap, Timothy A.; Carden, Craig P.; Kaye, Stan B. Nature Reviews Cancer, Vol. 9, Issue 3 https://doi.org/10.1038/nrc2583	journal	March 2009
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Ovarian Conservation at the Time of Hysterectomy and Long-Term Health Outcomes in the Nurses’ Health Study Parker, William H.; Broder, Michael S.; Chang, Eunice Obstetrics & Gynecology, Vol. 113, Issue 5 https://doi.org/10.1097/AOG.0b013e3181a11c64	journal	January 2009
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Mitochondrial Proteomic Analysis of Cisplatin Resistance in Ovarian Cancer Chappell, Nicole P.; Teng, Pang-ning; Hood, Brian L. Journal of Proteome Research, Vol. 11, Issue 9 https://doi.org/10.1021/pr300403d	journal	August 2012
Effectiveness of a Multivariate Index Assay in the Preoperative Assessment of Ovarian Tumors Ueland, Frederick R.; Desimone, Christopher P.; Seamon, Leigh G. Obstetrics & Gynecology, Vol. 117, Issue 6 https://doi.org/10.1097/AOG.0b013e31821b5118	journal	January 2011
The cell of origin of ovarian epithelial tumours Dubeau, Louis The Lancet Oncology, Vol. 9, Issue 12 https://doi.org/10.1016/S1470-2045(08)70308-5	journal	December 2008
A Randomized Study of Screening for Ovarian Cancer: A Multicenter Study in Japan Kobayashi, H.; Yamada, Y.; Sado, T. Obstetrical & Gynecological Survey, Vol. 63, Issue 10 https://doi.org/10.1097/01.ogx.0000333238.05419.56	journal	January 2008
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Phase III Trial of Carboplatin and Paclitaxel Compared With Cisplatin and Paclitaxel in Patients With Optimally Resected Stage III Ovarian Cancer: A Gynecologic Oncology Group Study Ozols, Robert F.; Bundy, Brian N.; Greer, Benjamin E. Journal of Clinical Oncology, Vol. 21, Issue 17 https://doi.org/10.1200/JCO.2003.02.153	journal	September 2003
Proteomic Analysis of Malignant Ovarian Cancer Effusions as a Tool for Biologic and Prognostic Profiling Davidson, B. Clinical Cancer Research, Vol. 12, Issue 3 https://doi.org/10.1158/1078-0432.CCR-05-2516	journal	February 2006
Highlights on the capacities of "Gel-based" proteomics Chevalier, François Proteome Science, Vol. 8, Issue 1 https://doi.org/10.1186/1477-5956-8-23	journal	January 2010
An overview of biomarkers for the ovarian cancer diagnosis Zhang, Bei; Cai, Feng Feng; Zhong, Xiao Yan European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 158, Issue 2 https://doi.org/10.1016/j.ejogrb.2011.04.023	journal	October 2011
Committee Opinion No. 477: The Role of the Obstetrician–Gynecologist in the Early Detection of Epithelial Ovarian Cancer Obstetrics & Gynecology, Vol. 117, Issue 3, p. 742-746 https://doi.org/10.1097/AOG.0b013e31821477db	journal	March 2011
Application of laser capture microdissection and proteomics in colon cancer Lawrie, L. C. Molecular Pathology, Vol. 54, Issue 4 https://doi.org/10.1136/mp.54.4.253	journal	August 2001
Differential exoprotease activities confer tumor-specific serum peptidome patterns Villanueva, Josep; Shaffer, David R.; Philip, John Journal of Clinical Investigation, Vol. 116, Issue 1, p. 271-284 https://doi.org/10.1172/JCI26022	journal	December 2005
Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. Ciechanover, A.; Schwartz, A. L.; Dautry-Varsat, A. Journal of Biological Chemistry, Vol. 258, Issue 16 https://doi.org/10.1016/S0021-9258(17)44551-0	journal	August 1983

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