Lethal body burdens of polar narcotics: Chlorophenols
- Utrecht Univ. (Netherlands). Environmental Chemistry Group
- Ministry of Transport, Public Works and Water Management, The Hague (Netherlands). National Institute for Coastal and Marine Management
The goal of the present study was to measure in fathead minnow (Pimephales promelas) the lethal body burden (LBB) of three chlorophenols that are known as polar narcotic chemicals. The LBBs of the chlorophenols were compared to LBBs of nonpolar narcotic chemicals to consider if the two classes of narcotic chemicals differ on a body burden level. The LBB of the most acidic chlorophenol was measured at two different levels of pH exposure to determine the influence of the degree of ionization on the magnitude of the LBB. Both n-octanol/water partition coefficients and n-hexane/water partition coefficients of the chlorophenols were determined at different pH levels to consider the influence of ionization on the partition coefficient and to determine the importance of a polar group in the organic phase on the partitioning behavior. Partitioning to n-octanol and n-hexane was used as input in a model to simulate the equilibrium partitioning between hydrophobic and nonhydrophobic and target and nontarget compartments in the fish.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 118684
- Journal Information:
- Environmental Toxicology and Chemistry, Vol. 14, Issue 9; Other Information: PBD: Sep 1995
- Country of Publication:
- United States
- Language:
- English
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