Whole-Genome Sequences of Thirteen Isolates of Borrelia burgdorferi

Journal Article · Tue Feb 01 00:00:00 EST 2011 · Journal of Bacteriology

DOI:https://doi.org/10.1128/JB.01158-10· OSTI ID:1044007

E, Schutzer S; Dunn, J; Fraser-Liggett, C M; Casjens, S R; Qiu, W -G; Mongodin, E F; Luft, B J

Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole-genome sequences of 13 additional B. burgdorferi isolates that span the range of natural variation. These sequences should allow improved understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies.

• Research Organization: Brookhaven National Lab. (BNL), Upton, NY (United States)
• Sponsoring Organization: NATIONAL INSTITUTE OF HEALTH
• DOE Contract Number: DE-AC02-98CH10886
• OSTI ID: 1044007
• Report Number(s): BNL-94775-2012-JA; JOBAAY; 400412000; TRN: US201214%%262
• Journal Information: Journal of Bacteriology, Vol. 193, Issue 4; ISSN 0021-9193
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DETECTION
DIAGNOSIS
DISEASES
PATHOGENESIS
PHENOTYPE
STRAINS
TICKS