Electrostatic Control of Bioactivity
Journal Article
·
· Angew. Chem. Int. Ed.
- NWU
The power of independence: When exhibited on the surface of self-assembling peptide-amphiphile nanofibers, the hydrophobic laminin-derived IKVAV epitope induced nanofiber bundling through interdigitation with neighboring fibers and thus decreased the bioactivity of the resulting materials. The inclusion of charged amino acids in the peptide amphiphiles disrupted the tendency to bundle and led to significantly enhanced neurite outgrowth.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- NSFFOREIGN
- OSTI ID:
- 1034181
- Journal Information:
- Angew. Chem. Int. Ed., Vol. 50, Issue (28) ; 07, 2011; ISSN 1433-7851
- Country of Publication:
- United States
- Language:
- ENGLISH
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