Contribution of maternal radionuclide burdens to prenatal radiation doses. Interim Recommendations: Revision 1
- Nuclear Regulatory Commission, Washington, DC (United States). Div. of Regulatory Applications
- Mound Lab., Miamisburg, OH (United States)
This report discusses approaches to calculating and expressing radiation doses to the embryo/fetus from internal radionuclides. Information was obtained for selected, occupationally significant radionuclides in chemical forms that provided a spectrum of metabolic and dosimetric characteristics. Fractional placental transfer and/or ratios of concentration in the embryo/fetus to that in the woman were estimated for these materials, and were combined with data from biokinetic transfer models to predict radioactivity levels in the embryo/fetus as a function of stage of pregnancy and time after entry into the transfer compartment or blood of the pregnant woman. Medical Internal Radiation Dosimetry (MIRD) methodologies were extended to formalize and describe details for calculating radiation absorbed doses to the embryo/fetus. Calculations were performed for representative situations; introduction of 1 {mu}Ci into a woman`s blood at successive months of pregnancy was assumed to accommodate the stage dependence of geometric relationships and biological behaviors. Summary tables of results, correlations, and dosimetric relations, and of tentative generalized categorizations, are provided in the report.
- Research Organization:
- Nuclear Regulatory Commission, Washington, DC (United States). Div. of Regulatory Applications; Pacific Northwest Lab., Richland, WA (United States)
- Sponsoring Organization:
- Nuclear Regulatory Commission, Washington, DC (United States)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 10137850
- Report Number(s):
- NUREG/CR-5631-Rev.1; PNL-7445-Rev.1; ON: TI92011387
- Resource Relation:
- Other Information: PBD: Mar 1992
- Country of Publication:
- United States
- Language:
- English
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