Characterisation of amorphous and nanocrystalline molecular materials by total scattering

Journal Article · Fri Sep 17 00:00:00 EDT 2010 · Cryst. Eng. Comm.

DOI:https://doi.org/10.1039/b915453a· OSTI ID:1002651

Billinge, Simon J.L.; Dykhne, Timur; Juhás, Pavol; Boin, Emil; Taylor, Ryan; Florence, Alastair J; Shankland, Kenneth ^[1]

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1. Reading

The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticals carbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III.

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
• Sponsoring Organization: USDOE
• OSTI ID: 1002651
• Journal Information: Cryst. Eng. Comm., Vol. 12, Issue 2010
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
77 NANOSCIENCE AND NANOTECHNOLOGY
AMORPHOUS STATE
NANOSTRUCTURES
CRYSTAL STRUCTURE
X-RAY DIFFRACTION
DISTRIBUTION FUNCTIONS
DRUGS