Functionalized Nanoporous Silica for Removal of Heavy Metals from Biological Systems; Adsorption and Application
Functionalized nanoporous silica, often referred to as self-assembled monolayers on mesoporous supports (SAMMS) have previously demonstrated the ability to serve as very effective heavy metal sorbents in a range of aquatic and environmental systems suggesting they may be advantageously utilized for biomedical applications such as chelation therapy. Herein we evaluate surface chemistries for heavy metal capture from biological fluids, various facets of the materials biocompatibility and the suitability of these materials as potential therapeutics. Of the materials tested, thiol-functionalized SAMMS proved most capable of removing selected heavy metals from biological solutions (i.e. blood, urine, etc.) As a result, thiol SAMMS was further analyzed to assess the material’s performance under a number of different biologically relevant conditions (i.e. variable pH and ionic strength) as well to gauge any potentially negative cellular effects resulting from interaction with the sorbent, such as cellular toxicity or possible chelation of essential minerals. Additionally, cellular uptake studies demonstrated no cell membrane permeation by the silica-based materials generally highlighting their ability to remain cellularly inert and thus non-toxic. As a result, it has been determined that organic ligand-functionalized nanoporous silica materials could be a valuable material for detoxification therapeutics and potentially other biomedical applications as needed.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1000623
- Report Number(s):
- PNNL-SA-73483; XW7272; 30433; 400412000; TRN: US201101%%421
- Journal Information:
- ACS Applied Materials & Interfaces, 2(10):2749-2758, Vol. 2, Issue 10; ISSN 1944-8244
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ADSORPTION
BLOOD
CELL MEMBRANES
DETOXIFICATION
HEAVY METALS
PERFORMANCE
REMOVAL
SILICA
THERAPY
THIOLS
TOXICITY
URINE
SAMMS
thiol
iminodiacetic acid
biocompatibility
heavy metal chelation
sorbent
ion exchange
resin
detoxification
nanoporous
mesoporous
heavy-metal chelation
SELF-ASSEMBLED MONOLAYERS
DRUG-DELIVERY SYSTEM
DRUGS
NATURAL-WATERS
PORE-SIZE
NANOPARTICLES
MCM-41
CANCER
Environmental Molecular Sciences Laboratory