Adsorption of Mixed Micelles of Polysorbate 80 and Oleic Acid to the Air–Water Interface

Ayati, Nooshin Sadat; Kanthe, Ankit D.; Krause, Mary; Zheng, Songyan; Zhang, Honghu; Ortuno Macias, Luis E.; Maldarelli, Charles; Tu, Raymond S.

doi:10.1021/acs.langmuir.5c05532

Title: Adsorption of Mixed Micelles of Polysorbate 80 and Oleic Acid to the Air–Water Interface

Journal Article · Mon Jan 05 00:00:00 UTC 2026 · Langmuir

DOI: https://doi.org/10.1021/acs.langmuir.5c05532 · OSTI ID:3014213

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City College of New York, NY (United States)
Bristol Myers Squibb, New Brunswick, NJ (United States)
Brookhaven National Laboratory (BNL), Upton, NY (United States)

The solubilization of long chain amphiphiles with limited solubility into mixed micelles composed of highly soluble surfactants plays a crucial role in modulating the stability and functionality of formulations in pharmaceutical and food systems. Subsequently, the mixed micelles adsorb from solution to the air−water surface, defining the transport mechanism of the insoluble amphiphiles to the interface. We use X-ray reflectivity to measure the composition and provide insight into the structure of these mixed monolayers, and, alongside interfacial tension measurements, we provide an understanding of how the bulk composition determines the surface composition and the dynamics of tension reduction. We use a model system consisting of an insoluble fatty acid, oleic acid (OA), and a soluble micelle-forming surfactant, polysorbate 80 (PS80). PS80 forms spherical micelles, and, above the critical micelle concentration (cmc), OA is readily solubilized inside the micelles. We show that the adsorption of PS80/OA mixed micelles to the air−water interface rapidly reduces the tension and lowers the equilibrium tension in proportion to the OA concentration. X-ray reflectivity data, fit using Parratt-slab models, quantitively demonstrates that the monolayers become enriched with OA, and we show how the OA intercalates into the PS80 monolayers.

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Research Organization:: Brookhaven National Lab; Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: Brookhaven National Lab; National Science Foundation (NSF); USDOE Office of Science (SC); USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF)

Grant/Contract Number:: SC0012704

OSTI ID:: 3014213

Report Number(s):: BNL-229361-2026-JAAM

Journal Information:: Langmuir, Journal Name: Langmuir Journal Issue: 2 Vol. 42; ISSN 0743-7463; ISSN 1520-5827

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Title: Adsorption of Mixed Micelles of Polysorbate 80 and Oleic Acid to the Air–Water Interface

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