The development and evolution of biological AMS at Livermore: a perspective

Bench, Graham

doi:10.1080/17576180.2025.2460391

Title: The development and evolution of biological AMS at Livermore: a perspective

Journal Article · Tue Feb 04 00:00:00 UTC 2025 · Bioanalysis

DOI: https://doi.org/10.1080/17576180.2025.2460391 · OSTI ID:2566953

Bench, Graham ^[1]

Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Biological accelerator mass spectrometry (AMS) provides ultrasensitive carbon-14 isotopic analysis enabling a deeper understanding of human health concerns by enabling quantification of pharmacokinetics and other molecular endpoints directly in humans. It enables environmentally and human relevant studies of metabolic pathways through the use of very low concentrations of labeled metabolic substrates in cells and organisms. Here, we discuss why AMS is an important tool for the biosciences, the development and evolution of biological AMS at Livermore and discuss technical refinements that will improve the efficiency of operation for the measurement of ultra-trace levels of ¹⁴C, which, long term, will enable greater ease of use and sample throughput.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 2566953

Report Number(s):: LLNL--JRNL-2001835

Journal Information:: Bioanalysis, Journal Name: Bioanalysis Journal Issue: 5 Vol. 17; ISSN 1757-6180

Publisher:: Future Science GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Absorption, Metabolism, and Excretion of ACT-1004-1239, a First-In-Class CXCR7 Antagonist: In Vitro, Preclinical, and Clinical Data Huynh, Christine; Seeland, Swen; Segrestaa, Jerome Frontiers in Pharmacology, Vol. 13 https://doi.org/10.3389/fphar.2022.812065	journal	March 2022
Separation of Lipoproteins for Quantitative Analysis of 14C-Labeled Lipid-Soluble Compounds by Accelerator Mass Spectrometry Chuang, Jennifer C.; Clifford, Andrew J.; Kim, Seung-Hyun International Journal of Molecular Sciences, Vol. 25, Issue 3 https://doi.org/10.3390/ijms25031856	journal	February 2024
14C-Cobalamin Absorption from Endogenously Labeled Chicken Eggs Assessed in Humans Using Accelerator Mass Spectrometry Nutrients, Vol. 11, Issue 9 https://doi.org/10.3390/nu11092148	journal	September 2019
A Minute Dose of 14C-β-Carotene Is Absorbed and Converted to Retinoids in Humans Ho, Charlene C.; de Moura, Fabiana F.; Kim, Seung-Hyun The Journal of Nutrition, Vol. 139, Issue 8 https://doi.org/10.3945/jn.109.105114	journal	June 2009
Accelerator mass spectrometry for quantification of micro- and therapeutic-dose diclofenac in microdialysis samples Langer, Oliver; Song, Jinho; Choi, Min Sun Bioanalysis, Vol. 14, Issue 16 https://doi.org/10.4155/bio-2022-0064	journal	August 2022

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Biological and medical sciences
accelerator mass spectrometry (AMS)
bioAMS
biological and medical sciences
carbon-14
distribution
human adsorption
metabolism and elimination studies
pharmacology
toxicology
ultra sensitive isotope detection

Title: The development and evolution of biological AMS at Livermore: a perspective

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