DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Introducing the Bacterial and Viral Bioinformatics Resource Center (BV-BRC): a resource combining PATRIC, IRD and ViPR

Journal Article · · Nucleic Acids Research
 [1];  [2];  [1];  [1];  [3]; ORCiD logo [1];  [4]; ORCiD logo [3];  [1];  [3];  [5]; ORCiD logo [4];  [6];  [3];  [7];  [3];  [5];  [1];  [8];  [1] more »;  [9];  [10];  [11];  [10];  [1];  [6];  [5];  [5];  [1];  [10];  [10];  [12];  [3];  [3]; ORCiD logo [1];  [1];  [5];  [5]; ORCiD logo [13]; ORCiD logo [14] « less
  1. Univ. of Chicago, IL (United States); Argonne National Laboratory (ANL), Argonne, IL (United States)
  2. American University of Beirut (Lebanon)
  3. Univ. of Virginia, Charlottesville, VA (United States)
  4. Univ. of Alabama, Birmingham, AL (United States)
  5. J. Craig Venter Institute, Inc., La Jolla, CA (United States)
  6. J. Craig Venter Institute, Inc., Rockville, MD (United States)
  7. Univ. of Auckland (New Zealand)
  8. Univ. of Illinois at Urbana-Champaign, IL (United States)
  9. Univ. of Chicago, IL (United States); Fellowship for Interpretation of Genomes, Burr Ridge, IL (United States)
  10. Fellowship for Interpretation of Genomes, Burr Ridge, IL (United States)
  11. Argonne National Laboratory (ANL), Argonne, IL (United States)
  12. Univ. of Alabama, Birmingham, AL (United States); Univ. of California, San Diego, CA (United States)
  13. J. Craig Venter Institute, Inc., La Jolla, CA (United States); Univ. of California, San Diego, CA (United States); La Jolla Institute for Immunology, La Jolla, CA (United States)
  14. Argonne National Laboratory (ANL), Argonne, IL (United States); Univ. of Chicago, IL (United States)

The National Institute of Allergy and Infectious Diseases (NIAID) established the Bioinformatics Resource Center (BRC) program to assist researchers with analyzing the growing body of genome sequence and other omics-related data. In this report, we describe the merger of the PAThosystems Resource Integration Center (PATRIC), the Influenza Research Database (IRD) and the Virus Pathogen Database and Analysis Resource (ViPR) BRCs to form the Bacterial and Viral Bioinformatics Resource Center (BV-BRC) https://www.bv-brc.org/. The combined BV-BRC leverages the functionality of the bacterial and viral resources to provide a unified data model, enhanced web-based visualization and analysis tools, bioinformatics services, and a powerful suite of command line tools that benefit the bacterial and viral research communities.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Organization:
National Institutes of Health (NIH), Bethesda, MD (United States); USDOE
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
2368570
Journal Information:
Nucleic Acids Research, Journal Name: Nucleic Acids Research Journal Issue: D1 Vol. 51; ISSN 0305-1048
Publisher:
Oxford University PressCopyright Statement
Country of Publication:
United States
Language:
English

References (61)

JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia journal April 2013
SLURM: Simple Linux Utility for Resource Management book January 2003
Protein Data Bank (PDB): The Single Global Macromolecular Structure Archive book January 2017
Metadata-driven comparative analysis tool for sequences (meta-CATS): An automated process for identifying significant sequence variations that correlate with virus attributes journal December 2013
Classification of human Herpesviridae proteins using Domain-architecture Aware Inference of Orthologs (DAIO) journal March 2019
Genomic evolution of the Coronaviridae family journal May 2022
Highly accurate protein structure prediction with AlphaFold journal July 2021
CheckV assesses the quality and completeness of metagenome-assembled viral genomes journal December 2020
AMRFinderPlus and the Reference Gene Catalog facilitate examination of the genomic links among antimicrobial resistance, stress response, and virulence journal June 2021
The FAIR Guiding Principles for scientific data management and stewardship journal March 2016
RASTtk: A modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes journal February 2015
A genomic data resource for predicting antimicrobial resistance from laboratory-derived antimicrobial susceptibility phenotypes journal August 2021
PATRIC as a unique resource for studying antimicrobial resistance journal July 2017
The Sequence Alignment/Map format and SAMtools journal June 2009
InterProScan 5: genome-scale protein function classification journal January 2014
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies journal January 2014
MSAViewer: interactive JavaScript visualization of multiple sequence alignments journal July 2016
Minimap2: pairwise alignment for nucleotide sequences journal May 2018
PHANOTATE: a novel approach to gene identification in phage genomes journal April 2019
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability journal January 2013
The Transporter Classification Database (TCDB): 2021 update journal November 2020
GenBank journal November 2020
Database resources of the National Center for Biotechnology Information journal October 2020
VFDB 2022: a general classification scheme for bacterial virulence factors journal November 2021
Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures journal May 2021
VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center journal October 2021
Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents journal October 2021
The Subsystems Approach to Genome Annotation and its Use in the Project to Annotate 1000 Genomes journal September 2005
PATRIC: The VBI PathoSystems Resource Integration Center journal January 2007
The National Microbial Pathogen Database Resource (NMPDR): a genomics platform based on subsystem annotation journal January 2007
BioHealthBase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence journal October 2007
ViPR: an open bioinformatics database and analysis resource for virology research journal October 2011
VIGOR extended to annotate genomes for additional 12 different viruses journal June 2012
Primer3—new capabilities and interfaces journal June 2012
The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST) journal November 2013
Influenza Research Database: An integrated bioinformatics resource for influenza virus research journal September 2016
DrugBank 5.0: a major update to the DrugBank database for 2018 journal November 2017
UniProt: a worldwide hub of protein knowledge November 2018
GenBank journal October 2018
Victors: a web-based knowledge base of virulence factors in human and animal pathogens journal October 2018
IEDB-AR: immune epitope database—analysis resource in 2019 journal May 2019
New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0 journal March 2010
Mauve: Multiple Alignment of Conserved Genomic Sequence With Rearrangements journal June 2004
Shock: Active Storage for Multicloud Streaming Data Analysis conference December 2015
Influenza response planning for the centers of excellence for influenza research and surveillance: Science preparedness for enhancing global health security journal April 2020
National Institute of Allergy and Infectious Diseases Bioinformatics Resource Centers: New Assets for Pathogen Informatics journal April 2007
phyloXML: XML for evolutionary biology and comparative genomics journal October 2009
BLAST+: architecture and applications journal January 2009
The RAST Server: Rapid Annotations using Subsystems Technology journal January 2008
JBrowse: a dynamic web platform for genome visualization and analysis journal April 2016
Mash: fast genome and metagenome distance estimation using MinHash journal June 2016
An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar journal January 2019
Improved metagenomic analysis with Kraken 2 journal November 2019
FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments journal March 2010
Standardized Metadata for Human Pathogen/Vector Genomic Sequences journal June 2014
Singularity: Scientific containers for mobility of compute journal May 2017
Early detection of emerging SARS-CoV-2 variants of interest for experimental evaluation journal October 2022
PATtyFams: Protein Families for the Microbial Genomes in the PATRIC Database journal February 2016
Virus Pathogen Database and Analysis Resource (ViPR): A Comprehensive Bioinformatics Database and Analysis Resource for the Coronavirus Research Community journal November 2012
Mash: fast genome and metagenome distance estimation using MinHash collection January 2016
An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar collection January 2019

Cited By (2)


Similar Records

PATRIC, the bacterial bioinformatics database and analysis resource
Journal Article · Tue Nov 12 00:00:00 UTC 2013 · Nucleic Acids Research · OSTI ID:1625514

The PATRIC Bioinformatics Resource Center: expanding data and analysis capabilities
Journal Article · Thu Oct 31 00:00:00 UTC 2019 · Nucleic Acids Research · OSTI ID:1633068

Improvements to PATRIC, the all-bacterial Bioinformatics Database and Analysis Resource Center
Journal Article · Mon Nov 28 00:00:00 UTC 2016 · Nucleic Acids Research · OSTI ID:1373595

Related Subjects