Search Menu
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information
Search Scholarly Publications

This content will become publicly available on Sat Sep 21 00:00:00 EDT 2024

Title: Production, isolation, and shipment of clinically relevant quantities of astatine-211: A simple and efficient approach to increasing supply

Abstract

The alpha emitter astatine-211 (211At) is a promising candidate for cancer treatment based on Targeted Alpha (α) Therapy (TAT). A small number of facilities, distributed across the United States, are capable of accelerating α-particle beams to produce 211At. However, challenges remain regarding strategic methods for shipping 211At in a form adaptable to advanced radiochemistry reactions and other uses of the radioisotope. Purpose: Our method allows shipment of 211At in various quantities in a form convenient for further radiochemistry. Procedures: For this study, a 3-octanone impregnated Amberchrom® CG300M resin bed in a column cartridge was used to separate 211At from the bismuth matrix on site at the production accelerator (Texas A&M) in preparation for shipping. Aliquots of 6 M HNO3 containing up to ≈2.22 GBq of 211At from the dissolved target were successfully loaded and retained on columns. Exempt packages (<370 MBq) were shipped to a destination radiochemistry facility, University of Texas MD Anderson Cancer Center, in the form of a convenient air-dried column. Type A packages have been shipped overnight to University of Alabama at Birmingham. Main findings: Air-dried column hold times of various lengths did not inhibit simple and efficient recovery of 211At. Solution eluted from the column wasmore » sufficiently high in specific activity to successfully radiolabel a model compound, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (1), with 211At. The method to prepare and ship 211At described in this manuscript has also been used to ship larger quantities of 211At a greater distance to University of Alabama at Birmingham. Principal conclusions: The successful proof of this method paves the way for the distribution of 211At from Texas A&M University to research institutions and clinical oncology centers in Texas and elsewhere. Finally, use of this simple method at other facilities has the potential increase the overall availability of 211At for preclinical and clinical studies.« less

Authors:
 [1];  [2];  [1];  [3];  [1];  [2];  [1];  [1];  [4];  [3];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1] more »;  [1];  [1];  [1] « less
+ Show Author Affiliations
  1. Texas A & M Univ., College Station, TX (United States). Cyclotron Institute
  2. Univ. of Alabama, Birmingham, AL (United States)
  3. Univ. of Texas, Houston, TX (United States). MD Anderson Cancer Center
  4. Univ. of Texas, Houston, TX (United States). MD Anderson Cancer Center and Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM)
Publication Date:
Research Org.:
Texas A & M Univ., College Station, TX (United States). Cyclotron Institute
Sponsoring Org.:
USDOE Office of Science (SC); USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
2331199
Grant/Contract Number:  
FG02-93ER40773; SC0020958; SC0022550; NA0003841
Resource Type:
Accepted Manuscript
Journal Name:
Nuclear Medicine and Biology
Additional Journal Information:
Journal Volume: 126-127; Journal ID: ISSN 0969-8051
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; Astatine-211; Radioisotope transport; Separations chemistry

Citation Formats

McIntosh, Lauren A., Burns, Jonathan D., Tereshatov, Evgeny E., Muzzioli, Riccardo, Hagel, Kris, Jinadu, Noimat A., McCann, Laura A., Picayo, Gabriela A., Pisaneschi, Federica, Piwnica-Worms, David, Schultz, Steven J., Tabacaru, Gabriel C., Abbott, Austin, Green, Brooklyn, Hankins, Travis, Hannaman, Andrew, Harvey, Bryan, Lofton, Kylie, Rider, Robert, Sorensen, Maxwell, Tabacaru, Alexandra, Tobin, Zachary, and Yennello, Sherry J. Production, isolation, and shipment of clinically relevant quantities of astatine-211: A simple and efficient approach to increasing supply. United States: N. p., 2023. Web. doi:10.1016/j.nucmedbio.2023.108387.
Copy to clipboard
McIntosh, Lauren A., Burns, Jonathan D., Tereshatov, Evgeny E., Muzzioli, Riccardo, Hagel, Kris, Jinadu, Noimat A., McCann, Laura A., Picayo, Gabriela A., Pisaneschi, Federica, Piwnica-Worms, David, Schultz, Steven J., Tabacaru, Gabriel C., Abbott, Austin, Green, Brooklyn, Hankins, Travis, Hannaman, Andrew, Harvey, Bryan, Lofton, Kylie, Rider, Robert, Sorensen, Maxwell, Tabacaru, Alexandra, Tobin, Zachary, & Yennello, Sherry J. Production, isolation, and shipment of clinically relevant quantities of astatine-211: A simple and efficient approach to increasing supply. United States. https://doi.org/10.1016/j.nucmedbio.2023.108387
Copy to clipboard
McIntosh, Lauren A., Burns, Jonathan D., Tereshatov, Evgeny E., Muzzioli, Riccardo, Hagel, Kris, Jinadu, Noimat A., McCann, Laura A., Picayo, Gabriela A., Pisaneschi, Federica, Piwnica-Worms, David, Schultz, Steven J., Tabacaru, Gabriel C., Abbott, Austin, Green, Brooklyn, Hankins, Travis, Hannaman, Andrew, Harvey, Bryan, Lofton, Kylie, Rider, Robert, Sorensen, Maxwell, Tabacaru, Alexandra, Tobin, Zachary, and Yennello, Sherry J. Thu . "Production, isolation, and shipment of clinically relevant quantities of astatine-211: A simple and efficient approach to increasing supply". United States. https://doi.org/10.1016/j.nucmedbio.2023.108387.
Copy to clipboard
@article{osti_2331199,
title = {Production, isolation, and shipment of clinically relevant quantities of astatine-211: A simple and efficient approach to increasing supply},
author = {McIntosh, Lauren A. and Burns, Jonathan D. and Tereshatov, Evgeny E. and Muzzioli, Riccardo and Hagel, Kris and Jinadu, Noimat A. and McCann, Laura A. and Picayo, Gabriela A. and Pisaneschi, Federica and Piwnica-Worms, David and Schultz, Steven J. and Tabacaru, Gabriel C. and Abbott, Austin and Green, Brooklyn and Hankins, Travis and Hannaman, Andrew and Harvey, Bryan and Lofton, Kylie and Rider, Robert and Sorensen, Maxwell and Tabacaru, Alexandra and Tobin, Zachary and Yennello, Sherry J.},
abstractNote = {The alpha emitter astatine-211 (211At) is a promising candidate for cancer treatment based on Targeted Alpha (α) Therapy (TAT). A small number of facilities, distributed across the United States, are capable of accelerating α-particle beams to produce 211At. However, challenges remain regarding strategic methods for shipping 211At in a form adaptable to advanced radiochemistry reactions and other uses of the radioisotope. Purpose: Our method allows shipment of 211At in various quantities in a form convenient for further radiochemistry. Procedures: For this study, a 3-octanone impregnated Amberchrom® CG300M resin bed in a column cartridge was used to separate 211At from the bismuth matrix on site at the production accelerator (Texas A&M) in preparation for shipping. Aliquots of 6 M HNO3 containing up to ≈2.22 GBq of 211At from the dissolved target were successfully loaded and retained on columns. Exempt packages (<370 MBq) were shipped to a destination radiochemistry facility, University of Texas MD Anderson Cancer Center, in the form of a convenient air-dried column. Type A packages have been shipped overnight to University of Alabama at Birmingham. Main findings: Air-dried column hold times of various lengths did not inhibit simple and efficient recovery of 211At. Solution eluted from the column was sufficiently high in specific activity to successfully radiolabel a model compound, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (1), with 211At. The method to prepare and ship 211At described in this manuscript has also been used to ship larger quantities of 211At a greater distance to University of Alabama at Birmingham. Principal conclusions: The successful proof of this method paves the way for the distribution of 211At from Texas A&M University to research institutions and clinical oncology centers in Texas and elsewhere. Finally, use of this simple method at other facilities has the potential increase the overall availability of 211At for preclinical and clinical studies.},
doi = {10.1016/j.nucmedbio.2023.108387},
journal = {Nuclear Medicine and Biology},
number = ,
volume = 126-127,
place = {United States},
year = {Thu Sep 21 00:00:00 EDT 2023},
month = {Thu Sep 21 00:00:00 EDT 2023}
}
Copy to clipboard
Journal Article:
Free Publicly Available Full Text
This content will become publicly available on September 21, 2024
Publisher's Version of Record
https://doi.org/10.1016/j.nucmedbio.2023.108387
Copyright Statement
Other availability
Search WorldCat Search WorldCat to find libraries that may hold this journal
Save / Share:
Export Metadata
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.

Works referenced in this record:

Astatine partitioning between nitric acid and conventional solvents: indication of covalency in ketone complexation of AtO +
journal, January 2020

  • Burns, Jonathan D.; Tereshatov, Evgeny E.; McCarthy, Mallory A.
  • Chemical Communications, Vol. 56, Issue 63
  • DOI: 10.1039/D0CC03804K

The Potential and Hurdles of Targeted Alpha Therapy – Clinical Trials and Beyond
journal, January 2014

An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211
journal, April 2017

Advances in 211At production at Texas A&M University
journal, January 2021

Nitrilotriacetate Complex of Univalent Astatine
journal, April 1992

Automated astatination of biomolecules – a stepping stone towards multicenter clinical trials
journal, July 2015

  • Aneheim, Emma; Albertsson, Per; Bäck, Tom
  • Scientific Reports, Vol. 5, Issue 1
  • DOI: 10.1038/srep12025

Synthesis of [211At]4-astato-L-phenylalanine by dihydroxyboryl-astatine substitution reaction in aqueous solution
journal, June 2021

Simple, Efficient Catalyst System for the Palladium-Catalyzed Amination of Aryl Chlorides, Bromides, and Triflates
journal, February 2000

  • Wolfe, John P.; Tomori, Hiroshi; Sadighi, Joseph P.
  • The Journal of Organic Chemistry, Vol. 65, Issue 4
  • DOI: 10.1021/jo991699y

Production, purification and availability of 211At: Near term steps towards global access
journal, September 2021

Recent progress of astatine-211 in endoradiotherapy: Great advances from fundamental properties to targeted radiopharmaceuticals
journal, July 2022

Preparation of no-carrier-added 211At solutions by a simple dry distillation method in the 209Bi(4He, 2n)211At reaction
journal, August 2020

  • Nishinaka, Ichiro; Ishioka, Noriko S.; Watanabe, Shigeki
  • Journal of Radioanalytical and Nuclear Chemistry, Vol. 326, Issue 1
  • DOI: 10.1007/s10967-020-07308-0

Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine
journal, September 2013

  • Balkin, Ethan; Hamlin, Donald; Gagnon, Katherine
  • Applied Sciences, Vol. 3, Issue 3
  • DOI: 10.3390/app3030636

The EDTA complexes of astatine
journal, June 1988

  • Milesz, S.; Jovchev, M.; Schumann, D.
  • Journal of Radioanalytical and Nuclear Chemistry Letters, Vol. 127, Issue 3
  • DOI: 10.1007/BF02164864

Extraction of 211At from nitric acid solutions into various organic solvents for use as an α-source for radiation chemistry studies
journal, July 2017

  • Ekberg, Christian; Jensen, Holger; Mezyk, Stephen P.
  • Journal of Radioanalytical and Nuclear Chemistry, Vol. 314, Issue 1
  • DOI: 10.1007/s10967-017-5364-1

Characterization of DTPA complexes and conjugated antibodies of astatine
journal, November 1989

  • Milesz, S.; Norseev, Yu. V.; Szücs, Z.
  • Journal of Radioanalytical and Nuclear Chemistry Letters, Vol. 137, Issue 5
  • DOI: 10.1007/BF02162464

Excitation function for the nuclear reaction
journal, June 1980

  • Meyer, G. -J.; Lambrecht, R. M.
  • The International Journal of Applied Radiation and Isotopes, Vol. 31, Issue 6
  • DOI: 10.1016/0020-708X(80)90125-8

PET Imaging of PARP Expression Using 18F-Olaparib
journal, November 2018

  • Wilson, Thomas C.; Xavier, Mary-Ann; Knight, James
  • Journal of Nuclear Medicine, Vol. 60, Issue 4
  • DOI: 10.2967/jnumed.118.213223

Rapid Cu-Catalyzed [ 211 At]Astatination and [ 125 I]Iodination of Boronic Esters at Room Temperature
journal, March 2018

Intraperitoneal  -Particle Radioimmunotherapy of Ovarian Cancer Patients: Pharmacokinetics and Dosimetry of 211At-MX35 F(ab')2--A Phase I Study
journal, June 2009

An improved 211 At-labeled agent for PSMA-targeted alpha therapy
journal, June 2021

Rapid recovery of At-211 by extraction chromatography
journal, February 2021

  • Burns, Jonathan D.; Tereshatov, Evgeny E.; Avila, Geoffrey
  • Separation and Purification Technology, Vol. 256
  • DOI: 10.1016/j.seppur.2020.117794

Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets
journal, December 2019

  • O’Hara, Matthew J.; Krzysko, Anthony J.; Hamlin, Donald K.
  • Scientific Reports, Vol. 9, Issue 1
  • DOI: 10.1038/s41598-019-56272-7

New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation
journal, May 1998

Harnessing α-Emitting Radionuclides for Therapy: Radiolabeling Method Review
journal, September 2021

The stability constants of chloride complexes of mono-valent astatine in nitric acid solution
journal, December 1968

18 F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography
journal, January 2016

Astatine-211 labelled a small molecule peptide: specific cell killing in vitro and targeted therapy in a nude-mouse model
journal, December 2020

An Overview of Targeted Alpha Therapy with 225 Actinium and 213 Bismuth
journal, October 2018

Questioning the Affinity of Electrophilic Astatine for Sulfur-containing Compounds: Unexpected Bindings Revealed
journal, September 2020

A Solid-State Support for Separating Astatine-211 from Bismuth
journal, April 2020

Targeted α-particle radiotherapy with 211At-labeled monoclonal antibodies
journal, October 2007

Production and Supply of α-Particle–Emitting Radionuclides for Targeted α-Therapy
journal, July 2021

  • Radchenko, Valery; Morgenstern, Alfred; Jalilian, Amir R.
  • Journal of Nuclear Medicine, Vol. 62, Issue 11
  • DOI: 10.2967/jnumed.120.261016

Radioimmunotherapy with alpha-emitting nuclides
journal, September 1998

  • McDevitt, Michael R.; Sgouros, George; Finn, Ronald D.
  • European Journal of Nuclear Medicine and Molecular Imaging, Vol. 25, Issue 9
  • DOI: 10.1007/s002590050306

Molecular Pathways: Targeted  -Particle Radiation Therapy
journal, December 2012

Separation, speciation, and mechanism of astatine and bismuth extraction from nitric acid into 1-octanol and methyl anthranilate
journal, February 2022

  • Tereshatov, Evgeny E.; Burns, Jonathan D.; Vonder Haar, Amy L.
  • Separation and Purification Technology, Vol. 282
  • DOI: 10.1016/j.seppur.2021.120088

211 Rn/ 211 At and 209 At production with intense mass separated Fr ion beams for preclinical 211 At-based α-therapy research
journal, April 2017

Complexation of Astatine(III) with Ketones: Roles of NO3– Counterion and Exploration of Possible Binding Modes
journal, July 2022

Feasibility of the radioastatination of a monoclonal antibody with astatine-211 purified by wet extraction
journal, October 2008

  • Bourgeois, Mickaël; Guerard, François; Alliot, Cyrille
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 51, Issue 11
  • DOI: 10.1002/jlcr.1543

Compact automated apparatus for rapid astatine recovery from nitric acid media: Design, application, and impurity characterization
journal, August 2022

  • Tereshatov, Evgeny E.; Burns, Jonathan D.; Schultz, Steven J.
  • Chemical Engineering Journal, Vol. 442
  • DOI: 10.1016/j.cej.2022.136176

Extraction of astatine-211 in diisopropylether (DIPE)
journal, January 2009

  • Alliot, Cyrille; Chérel, Michel; Barbet, Jacques
  • Radiochimica Acta, Vol. 97, Issue 3
  • DOI: 10.1524/ract.2009.1590

Mechanism of astatine and bismuth sorption on extraction chromatography resins from nitric acid media
journal, May 2023

  • Tereshatov, Evgeny E.; Burns, Jonathan D.; Schultz, Steven J.
  • Chemical Engineering Journal, Vol. 464
  • DOI: 10.1016/j.cej.2023.142742

Development of a preclinical 211 Rn/ 211 At generator system for targeted alpha therapy research with 211 At
journal, May 2017

Ion exchange behavior of astatine and bismuth
journal, January 2023

  • Tereshatov, Evgeny E.; Burns, Jonathan D.; Schultz, Steven J.
  • New Journal of Chemistry, Vol. 47, Issue 25
  • DOI: 10.1039/D3NJ01316B

Highly Stereocontrolled One-Step Synthesis ofanti-β-Amino Alcohols from Organoboronic Acids, Amines, and α-Hydroxy Aldehydes
journal, October 1998

  • Petasis, Nicos A.; Zavialov, Ilia A.
  • Journal of the American Chemical Society, Vol. 120, Issue 45
  • DOI: 10.1021/ja981075u

Measurements of the excitation functions of radon and astatine isotopes from 7Li-induced reactions with 209Bi for development of a 211Rn–211At generator
journal, December 2019

  • Maeda, Eita; Yokoyama, Akihiko; Taniguchi, Takumi
  • Journal of Radioanalytical and Nuclear Chemistry, Vol. 323, Issue 2
  • DOI: 10.1007/s10967-019-06990-z

Astatine-211: Production and Availability
journal, July 2011

    Sort by:
    [ × clear filter / sort ]

    Similar Records in DOE PAGES and OSTI.GOV collections: