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Title: Modifications to Nano- and Microstructural Quality and the Effects on Mechanical Integrity in Paget's Disease of Bone

Abstract

ABSTRACT   Paget's disease of bone (PDB) is the second most common bone disease mostly developing after 50 years of age at one or more localized skeletal sites; it is associated with severely high bone turnover, bone enlargement, bowing/deformity, cracking, and pain. Here, to specifically address the origins of the deteriorated mechanical integrity, we use a cohort of control and PDB human biopsies to investigate multiscale architectural and compositional modifications to the bone structure (ie, bone quality) and relate these changes to mechanical property measurements to provide further insight into the clinical manifestations (ie, deformities and bowing) and fracture risk caused by PDB. Here, at the level of the collagen and mineral (ie, nanometer-length scale), we find a 19% lower mineral content and lower carbonate-to-phosphate ratio in PDB, which accounts for the 14% lower stiffness and 19% lower hardness promoting plastic deformation in pathological bone. At the microstructural scale, trabecular regions are known to become densified, whereas cortical bone loses its characteristic parallel-aligned osteonal pattern, which is replaced with a mosaic of lamellar and woven bone. Although we find this loss of anisotropic alignment produces a straighter crack path in mechanically-loaded PDB cases, cortical fracture toughness appears to be maintainedmore » due to increased plastic deformation. Clearly, the altered quality of the bone structure in PDB affects the mechanical integrity leading to complications such as bowing, deformities, and stable cracks called fissure fractures associated with this disease. Although the lower mineralization and loss of aligned Haversian structures do produce a lower modulus tissue, which is susceptible to deformities, our results indicate that the higher levels of plasticity may compensate for the lost microstructural features and maintain the resistance to crack growth. © 2014 American Society for Bone and Mineral Research« less

Authors:
; ; ; ; ; ; ; ; ;
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
2283999
Resource Type:
Published Article
Journal Name:
Journal of Bone and Mineral Research
Additional Journal Information:
Journal Name: Journal of Bone and Mineral Research Journal Volume: 30 Journal Issue: 2; Journal ID: ISSN 0884-0431
Publisher:
Oxford University Press
Country of Publication:
United States
Language:
English

Citation Formats

Zimmermann, Elizabeth A., Köhne, Till, Bale, Hrishikesh A., Panganiban, Brian, Gludovatz, Bernd, Zustin, Joszef, Hahn, Michael, Amling, Michael, Ritchie, Robert O., and Busse, Björn. Modifications to Nano- and Microstructural Quality and the Effects on Mechanical Integrity in Paget's Disease of Bone. United States: N. p., 2014. Web. doi:10.1002/jbmr.2340.
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Zimmermann, Elizabeth A., Köhne, Till, Bale, Hrishikesh A., Panganiban, Brian, Gludovatz, Bernd, Zustin, Joszef, Hahn, Michael, Amling, Michael, Ritchie, Robert O., & Busse, Björn. Modifications to Nano- and Microstructural Quality and the Effects on Mechanical Integrity in Paget's Disease of Bone. United States. https://doi.org/10.1002/jbmr.2340
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Zimmermann, Elizabeth A., Köhne, Till, Bale, Hrishikesh A., Panganiban, Brian, Gludovatz, Bernd, Zustin, Joszef, Hahn, Michael, Amling, Michael, Ritchie, Robert O., and Busse, Björn. Tue . "Modifications to Nano- and Microstructural Quality and the Effects on Mechanical Integrity in Paget's Disease of Bone". United States. https://doi.org/10.1002/jbmr.2340.
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@article{osti_2283999,
title = {Modifications to Nano- and Microstructural Quality and the Effects on Mechanical Integrity in Paget's Disease of Bone},
author = {Zimmermann, Elizabeth A. and Köhne, Till and Bale, Hrishikesh A. and Panganiban, Brian and Gludovatz, Bernd and Zustin, Joszef and Hahn, Michael and Amling, Michael and Ritchie, Robert O. and Busse, Björn},
abstractNote = {ABSTRACT   Paget's disease of bone (PDB) is the second most common bone disease mostly developing after 50 years of age at one or more localized skeletal sites; it is associated with severely high bone turnover, bone enlargement, bowing/deformity, cracking, and pain. Here, to specifically address the origins of the deteriorated mechanical integrity, we use a cohort of control and PDB human biopsies to investigate multiscale architectural and compositional modifications to the bone structure (ie, bone quality) and relate these changes to mechanical property measurements to provide further insight into the clinical manifestations (ie, deformities and bowing) and fracture risk caused by PDB. Here, at the level of the collagen and mineral (ie, nanometer-length scale), we find a 19% lower mineral content and lower carbonate-to-phosphate ratio in PDB, which accounts for the 14% lower stiffness and 19% lower hardness promoting plastic deformation in pathological bone. At the microstructural scale, trabecular regions are known to become densified, whereas cortical bone loses its characteristic parallel-aligned osteonal pattern, which is replaced with a mosaic of lamellar and woven bone. Although we find this loss of anisotropic alignment produces a straighter crack path in mechanically-loaded PDB cases, cortical fracture toughness appears to be maintained due to increased plastic deformation. Clearly, the altered quality of the bone structure in PDB affects the mechanical integrity leading to complications such as bowing, deformities, and stable cracks called fissure fractures associated with this disease. Although the lower mineralization and loss of aligned Haversian structures do produce a lower modulus tissue, which is susceptible to deformities, our results indicate that the higher levels of plasticity may compensate for the lost microstructural features and maintain the resistance to crack growth. © 2014 American Society for Bone and Mineral Research},
doi = {10.1002/jbmr.2340},
journal = {Journal of Bone and Mineral Research},
number = 2,
volume = 30,
place = {United States},
year = {Tue Aug 12 00:00:00 EDT 2014},
month = {Tue Aug 12 00:00:00 EDT 2014}
}
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Works referenced in this record:

The Second Most Common Bone Disease: A Review on Paget’s Disease of Bone
journal, November 2008

  • Seitz, Sebastian; Priemel, Matthias; von Domarus, Christoph
  • European Journal of Trauma and Emergency Surgery, Vol. 34, Issue 6
  • DOI: 10.1007/s00068-008-8208-4

Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization
journal, March 2013

Complete fractures of the femur in Paget's disease of bone
journal, February 1980

Bone mineralization density distribution in health and disease
journal, March 2008

Bone histomorphometry in pacet's disease quantitative and dynamic analysis of pagetic and nonpagetic bone tissue
journal, October 1980

  • Meunier, Pierre J.; Coindre, Jean M.; Edouard, Claude M.
  • Arthritis & Rheumatism, Vol. 23, Issue 10
  • DOI: 10.1002/art.1780231005

Bone tissue in paget's disease of bone ultrastructure and immunocytology
journal, October 1980

Vitamin D Deficiency Induces Early Signs of Aging in Human Bone, Increasing the Risk of Fracture
journal, July 2013

  • Busse, Björn; Bale, Hrishikesh A.; Zimmermann, Elizabeth A.
  • Science Translational Medicine, Vol. 5, Issue 193
  • DOI: 10.1126/scitranslmed.3006286

Incidence and Natural History of Paget's Disease of Bone in England and Wales
journal, March 2002

  • Van Staa, T. P.; Selby, P.; Leufkens, H. G. M.
  • Journal of Bone and Mineral Research, Vol. 17, Issue 3
  • DOI: 10.1359/jbmr.2002.17.3.465

The Management of Paget's Disease of Bone
journal, February 1997

Slightly curved or kinked cracks
journal, April 1980

  • Cotterell, B.; Rice, J. R.
  • International Journal of Fracture, Vol. 16, Issue 2
  • DOI: 10.1007/BF00012619

Spectroscopic Characterization of Collagen Cross-Links in Bone
journal, October 2001

Epidemiology of Paget's disease of bone: A systematic review and meta-analysis of secular changes
journal, August 2013

  • Corral-Gudino, Luis; Borao-Cengotita-Bengoa, Maria; Del Pino-Montes, Javier
  • Bone, Vol. 55, Issue 2
  • DOI: 10.1016/j.bone.2013.04.024

Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales
journal, August 2011

  • Zimmermann, E. A.; Schaible, E.; Bale, H.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 35
  • DOI: 10.1073/pnas.1107966108

Mineralized Collagen Fibrils: A Mechanical Model with a Staggered Arrangement of Mineral Particles
journal, October 2000

Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients
journal, January 2010

  • Priemel, Matthias; von Domarus, Christoph; Klatte, Till Orla
  • Journal of Bone and Mineral Research, Vol. 25, Issue 2
  • DOI: 10.1359/jbmr.090728

The mechanical consequences of variation in the mineral content of bone
journal, March 1969

Structural differences between “dark” and “bright” isolated human osteonic lamellae
journal, January 2003

  • Ascenzi, Maria-Grazia; Ascenzi, Antonio; Benvenuti, Alessandro
  • Journal of Structural Biology, Vol. 141, Issue 1
  • DOI: 10.1016/S1047-8477(02)00578-6

Collagen orientation in compact bone: I. A new method for the determination of the proportion of collagen parallel to the plane of compact bone sections
journal, January 1984

  • Boyde, A.; Bianco, P.; Portigliatti Barbos, M.
  • Metabolic Bone Disease and Related Research, Vol. 5, Issue 6
  • DOI: 10.1016/0221-8747(84)90017-1

Trends in trabecular architecture and bone mineral density distribution in 152 individuals aged 30–90years
journal, September 2014

Radiographic Diagnosis and Laboratory Evaluation of Paget's Disease of Bone
journal, January 2002

  • Cushing, Frederick R.; Bone, Henry G.
  • Clinical Reviews in Bone and Mineral Metabolism, Vol. 1, Issue 2
  • DOI: 10.1385/BMM:1:2:115

The Mineralization Density of Iliac Crest Bone from Children with Osteogenesis Imperfecta
journal, March 1999

  • Boyde, A.; Travers, R.; Glorieux, F. H.
  • Calcified Tissue International, Vol. 64, Issue 3
  • DOI: 10.1007/s002239900600

Paget's disease of bone : the anatomical distribution
journal, January 1981

Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone
journal, December 2011

Changes to the cell, tissue and architecture levels in cranial suture synostosis reveal a problem of timing in bone development
journal, November 2012

  • Regelsberger, J.; Milovanovic, P.; Schmidt, T.
  • European Cells and Materials, Vol. 24
  • DOI: 10.22203/eCM.v024a31

Microindentation for in vivo measurement of bone tissue mechanical properties in humans
journal, February 2010

  • Diez-Perez, Adolfo; Güerri, Roberto; Nogues, Xavier
  • Journal of Bone and Mineral Research, Vol. 25, Issue 8
  • DOI: 10.1002/jbmr.73

Effects of tissue age on bone tissue material composition and nanomechanical properties in the rat cortex
journal, March 2009

  • Donnelly, Eve; Boskey, Adele L.; Baker, Shefford P.
  • Journal of Biomedical Materials Research Part A, Vol. 92A, Issue 3
  • DOI: 10.1002/jbm.a.32442

Paget's Disease of Bone
journal, July 1998

A Clinical Approach to Diagnosis and Management of Paget's Disease of Bone
journal, August 2001

  • Lyles, Kenneth W.; Siris, Ethel S.; Singer, Frederick R.
  • Journal of Bone and Mineral Research, Vol. 16, Issue 8
  • DOI: 10.1359/jbmr.2001.16.8.1379

The true toughness of human cortical bone measured with realistically short cracks
journal, June 2008

  • Koester, K. J.; Ager, J. W.; Ritchie, R. O.
  • Nature Materials, Vol. 7, Issue 8
  • DOI: 10.1038/nmat2221

Correlative Light and Scanning X-Ray Scattering Microscopy of Healthy and Pathologic Human Bone Sections
journal, May 2012

  • Giannini, C.; Siliqi, D.; Bunk, O.
  • Scientific Reports, Vol. 2, Issue 1
  • DOI: 10.1038/srep00435

How Tough Is Brittle Bone? Investigating Osteogenesis Imperfecta in Mouse Bone: FRACTURE TOUGHNESS OF OIM BONE
journal, May 2014

  • Carriero, Alessandra; Zimmermann, Elizabeth A.; Paluszny, Adriana
  • Journal of Bone and Mineral Research, Vol. 29, Issue 6
  • DOI: 10.1002/jbmr.2172

Management of fissure fractures in Paget's disease
journal, July 1981

  • Redden, J. F.; Dixon, J.; Vennart, W.
  • International Orthopaedics, Vol. 5, Issue 2
  • DOI: 10.1007/BF00267839

Paget's Disease of Bone in Italy
journal, December 2006

  • Gennari, Luigi; Merlotti, Daniela; Martini, Giuseppe
  • Journal of Bone and Mineral Research, Vol. 21, Issue S2
  • DOI: 10.1359/jbmr.06s203

Biochemical Assessment of Paget's Disease of Bone
journal, December 2006

  • Shankar, Subramanian; Hosking, David J.
  • Journal of Bone and Mineral Research, Vol. 21, Issue S2
  • DOI: 10.1359/jbmr.06s204

The Ratio 1660/1690 cm−1 Measured by Infrared Microspectroscopy Is Not Specific of Enzymatic Collagen Cross-Links in Bone Tissue
journal, December 2011

On a Form of Chronic Inflammation of Bones (Osteitis Deformans)
journal, January 1877

Paget's disease of bone and quality of life
journal, December 1996

  • Gold, Deborah T.; Boisture, Jennifer; Shipp, Kathy M.
  • Journal of Bone and Mineral Research, Vol. 11, Issue 12
  • DOI: 10.1002/jbmr.5650111210

The Effect of NaF In Vitro on the Mechanical and Material Properties of Trabecular and Cortical Bone
journal, January 2009

  • Thurner, Philipp J.; Erickson, Blake; Turner, Patricia
  • Advanced Materials, Vol. 21, Issue 4
  • DOI: 10.1002/adma.200801204

Paget's Disease of Bone: Histologic Analysis of 754 Patients
journal, January 2009

  • Seitz, Sebastian; Priemel, Matthias; Zustin, Jozef
  • Journal of Bone and Mineral Research, Vol. 24, Issue 1
  • DOI: 10.1359/jbmr.080907

Paget disease of the spine: an evaluation of 101 patients with a histomorphometric analysis of 29 cases
journal, December 2011

Clinical Vignette: Natural History of Untreated Paget's Disease of the Tibia
journal, April 1997

Fractures of the Femur in Paget'S Disease of bone
journal, May 1970

Randomized trial of intensive bisphosphonate treatment versus symptomatic management in paget's disease of bone
journal, January 2010

  • Langston, Anne L.; Campbell, Marion K.; Fraser, William D.
  • Journal of Bone and Mineral Research, Vol. 25, Issue 1
  • DOI: 10.1359/jbmr.090709

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee
journal, December 2012

  • Dempster, David W.; Compston, Juliet E.; Drezner, Marc K.
  • Journal of Bone and Mineral Research, Vol. 28, Issue 1
  • DOI: 10.1002/jbmr.1805

Paget's Disease of Bone
journal, February 2013

Influence of mineral content and composition on graylevels in backscattered electron images of bone
journal, January 1993

  • Skedros, John G.; Bloebaum, Roy D.; Bachus, Kent N.
  • Journal of Biomedical Materials Research, Vol. 27, Issue 1
  • DOI: 10.1002/jbm.820270108

On the Mechanistic Origins of Toughness in Bone
journal, June 2010

Mineral maturity and crystallinity index are distinct characteristics of bone mineral
journal, January 2010

  • Farlay, Delphine; Panczer, Gérard; Rey, Christian
  • Journal of Bone and Mineral Metabolism, Vol. 28, Issue 4
  • DOI: 10.1007/s00774-009-0146-7

FT-IR imaging of native and tissue-engineered bone and cartilage
journal, May 2007

Fracture Risk Among Patients with Paget's Disease: A Population‐Based Cohort Study
journal, November 2000

  • Melton, L. Joseph; Tiegs, Robert D.; Atkinson, Elizabeth J.
  • Journal of Bone and Mineral Research, Vol. 15, Issue 11
  • DOI: 10.1359/jbmr.2000.15.11.2123

Paget’s disease of bone: a review of 889 patients
journal, May 1999

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