Altered cortical thickness-based structural covariance networks in type 2 diabetes mellitus
Abstract
Cognitive impairment is a common complication of type 2 diabetes mellitus (T2DM), and early cognitive dysfunction may be associated with abnormal changes in the cerebral cortex. This retrospective study aimed to investigate the cortical thickness-based structural topological network changes in T2DM patients without mild cognitive impairment (MCI). Fifty-six T2DM patients and 59 healthy controls underwent neuropsychological assessments and sagittal 3-dimensional T1-weighted structural magnetic resonance imaging. Then, we combined cortical thickness-based assessments with graph theoretical analysis to explore the abnormalities in structural covariance networks in T2DM patients. Correlation analyses were performed to investigate the relationship between the altered topological parameters and cognitive/clinical variables. T2DM patients exhibited significantly lower clustering coefficient (C) and local efficiency (Elocal) values and showed nodal property disorders in the occipital cortical, inferior temporal, and inferior frontal regions, the precuneus, and the precentral and insular gyri. Moreover, the structural topological network changes in multiple nodes were correlated with the findings of neuropsychological tests in T2DM patients. Thus, while T2DM patients without MCI showed a relatively normal global network, the local topological organization of the structural network was disordered. Moreover, the impaired ventral visual pathway may be involved in the neural mechanism of visual cognitive impairment in T2DM patients.more »
- Authors:
- Publication Date:
- Sponsoring Org.:
- USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
- OSTI Identifier:
- 2282659
- Resource Type:
- Published Article
- Journal Name:
- Frontiers in Neuroscience (Online)
- Additional Journal Information:
- Journal Name: Frontiers in Neuroscience (Online) Journal Volume: 18; Journal ID: ISSN 1662-453X
- Publisher:
- Frontiers Media SA
- Country of Publication:
- Switzerland
- Language:
- English
Citation Formats
Huang, Yang, Zhang, Xin, Cheng, Miao, Yang, Zhen, Liu, Wanting, Ai, Kai, Tang, Min, Zhang, Xiaoling, Lei, Xiaoyan, and Zhang, Dongsheng. Altered cortical thickness-based structural covariance networks in type 2 diabetes mellitus. Switzerland: N. p., 2024.
Web. doi:10.3389/fnins.2024.1327061.
Huang, Yang, Zhang, Xin, Cheng, Miao, Yang, Zhen, Liu, Wanting, Ai, Kai, Tang, Min, Zhang, Xiaoling, Lei, Xiaoyan, & Zhang, Dongsheng. Altered cortical thickness-based structural covariance networks in type 2 diabetes mellitus. Switzerland. https://doi.org/10.3389/fnins.2024.1327061
Huang, Yang, Zhang, Xin, Cheng, Miao, Yang, Zhen, Liu, Wanting, Ai, Kai, Tang, Min, Zhang, Xiaoling, Lei, Xiaoyan, and Zhang, Dongsheng. Wed .
"Altered cortical thickness-based structural covariance networks in type 2 diabetes mellitus". Switzerland. https://doi.org/10.3389/fnins.2024.1327061.
@article{osti_2282659,
title = {Altered cortical thickness-based structural covariance networks in type 2 diabetes mellitus},
author = {Huang, Yang and Zhang, Xin and Cheng, Miao and Yang, Zhen and Liu, Wanting and Ai, Kai and Tang, Min and Zhang, Xiaoling and Lei, Xiaoyan and Zhang, Dongsheng},
abstractNote = {Cognitive impairment is a common complication of type 2 diabetes mellitus (T2DM), and early cognitive dysfunction may be associated with abnormal changes in the cerebral cortex. This retrospective study aimed to investigate the cortical thickness-based structural topological network changes in T2DM patients without mild cognitive impairment (MCI). Fifty-six T2DM patients and 59 healthy controls underwent neuropsychological assessments and sagittal 3-dimensional T1-weighted structural magnetic resonance imaging. Then, we combined cortical thickness-based assessments with graph theoretical analysis to explore the abnormalities in structural covariance networks in T2DM patients. Correlation analyses were performed to investigate the relationship between the altered topological parameters and cognitive/clinical variables. T2DM patients exhibited significantly lower clustering coefficient (C) and local efficiency (Elocal) values and showed nodal property disorders in the occipital cortical, inferior temporal, and inferior frontal regions, the precuneus, and the precentral and insular gyri. Moreover, the structural topological network changes in multiple nodes were correlated with the findings of neuropsychological tests in T2DM patients. Thus, while T2DM patients without MCI showed a relatively normal global network, the local topological organization of the structural network was disordered. Moreover, the impaired ventral visual pathway may be involved in the neural mechanism of visual cognitive impairment in T2DM patients. This study enriched the characteristics of gray matter structure changes in early cognitive dysfunction in T2DM patients.},
doi = {10.3389/fnins.2024.1327061},
journal = {Frontiers in Neuroscience (Online)},
number = ,
volume = 18,
place = {Switzerland},
year = {Wed Jan 24 00:00:00 EST 2024},
month = {Wed Jan 24 00:00:00 EST 2024}
}
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