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Title: Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortium

Journal Article · · International Journal of Cancer
DOI: https://doi.org/10.1002/ijc.34794 · OSTI ID:2222532
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  1. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan
  2. Division of Cancer Information and Control, Department of Preventive Medicine Aichi Cancer Center Research Institute Nagoya Japan, Division of Descriptive Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan
  3. Division of Cancer Information and Control, Department of Preventive Medicine Aichi Cancer Center Research Institute Nagoya Japan
  4. Division of Prevention National Cancer Center Institute for Cancer Control Tokyo Japan
  5. Division of Prevention National Cancer Center Institute for Cancer Control Tokyo Japan, Research Center for Child Mental Development Hamamatsu University School of Medicine Hamamatsu Japan
  6. Division of Prevention National Cancer Center Institute for Cancer Control Tokyo Japan, Hitotsubashi Institute for Advanced Study Hitotsubashi University Tokyo Japan
  7. Institute for Global Health Policy Research National Center for Global Health and Medicine Tokyo Japan
  8. Healis—Sekhsaria Institute for Public Health Navi Mumbai India
  9. Division of Cohort Research National Cancer Center Institute for Cancer Control Tokyo Japan
  10. Department of Public Health Hokkaido University Faculty of Medicine Sapporo Japan
  11. Division of Epidemiology, Department of Medicine Vanderbilt Epidemiology Center, Vanderbilt‐Ingram Cancer Center, Vanderbilt University Medical Center Nashville Tennessee USA
  12. Radiation Effects Research Foundation Hiroshima Japan
  13. Digestive Oncology Research Center, Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran
  14. Tohoku University Graduate School of Medicine Miyagi Japan
  15. Graduate School of Cancer Science and Policy, National Cancer Center Goyang Korea
  16. Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine Gifu Japan
  17. School of Medicine &, Big Data Research Center Fu Jen Catholic University Taipei Taiwan
  18. Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea
  19. Division of Cancer Control and Population Sciences UPMC Hillman Cancer Center, University of Pittsburgh Pittsburgh Pennsylvania USA, Department of Epidemiology Graduate School of Public Health, University of Pittsburgh Pittsburgh Pennsylvania USA
  20. Department of Social and Preventive Medicine Sungkyunkwan University School of Medicine Gyeonggi‐do Korea
  21. Department of Preventive Medicine Chonnam National University Medical School Gwangju Korea
  22. Division of Cohort Research National Cancer Center Institute for Cancer Control Tokyo Japan, National Institute of Health and Nutrition National Institutes of Biomedical Innovation, Health and Nutrition Tokyo Japan
  23. Department of Epidemiology Shanghai Cancer Institute Shanghai China, Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai China
  24. Digestive Diseases Research institute Tehran University of Medical Science Tehran Iran
  25. Genomics Research Center, Academia Sinica Taipei Taiwan
  26. Departments of Population Health and Environmental Medicine NYU Grossman School of Medicine New York New York USA
  27. Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea, Cancer Research Institute Seoul National University Seoul Korea
  28. Division of Cancer Control and Population Sciences UPMC Hillman Cancer Center, University of Pittsburgh Pittsburgh Pennsylvania USA
  29. Department of Public Health Sciences University of Chicago Chicago Illinois USA
  30. Stony Brook Cancer Center Stony Brook University Stony Brook New York USA, Department of Medical and Surgical Sciences University of Bologna Bologna Italy
  31. Saw Swee Hock School of Public Health National University of Singapore Singapore Singapore
  32. School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
  33. Division of Cancer Epidemiology and Genetics Occupational and Environmental Epidemiology Branch, National Cancer Institute Bethesda Maryland USA
  34. Seoul National University College of Medicine Seoul Korea
  35. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan, Department of Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan
+ Show Author Affiliations

Abstract Body fatness is considered a probable risk factor for biliary tract cancer (BTC), whereas cholelithiasis is an established factor. Nevertheless, although obesity is an established risk factor for cholelithiasis, previous studies of the association of body mass index (BMI) and BTC did not take the effect of cholelithiasis fully into account. To better understand the effect of BMI on BTC, we conducted a pooled analysis using population‐based cohort studies in Asians. In total, 905 530 subjects from 21 cohort studies participating in the Asia Cohort Consortium were included. BMI was categorized into four groups: underweight (<18.5 kg/m 2 ); normal (18.5‐22.9 kg/m 2 ); overweight (23‐24.9 kg/m 2 ); and obese (25+ kg/m 2 ). The association between BMI and BTC incidence and mortality was assessed using hazard ratios (HR) and 95% confidence intervals (CIs) by Cox regression models with shared frailty. Mediation analysis was used to decompose the association into a direct and an indirect (mediated) effect. Compared to normal BMI, high BMI was associated with BTC mortality (HR 1.19 [CI 1.02‐1.38] for males, HR 1.30 [1.14‐1.49] for females). Cholelithiasis had significant interaction with BMI on BTC risk. BMI was associated with BTC risk directly and through cholelithiasis in females, whereas the association was unclear in males. When cholelithiasis was present, BMI was not associated with BTC death in either males or females. BMI was associated with BTC death among females without cholelithiasis. This study suggests BMI is associated with BTC mortality in Asians. Cholelithiasis appears to contribute to the association; and moreover, obesity appears to increase BTC risk without cholelithiasis.

Sponsoring Organization:
USDOE
OSTI ID:
2222532
Journal Information:
International Journal of Cancer, Journal Name: International Journal of Cancer Journal Issue: 7 Vol. 154; ISSN 0020-7136
Publisher:
Wiley Blackwell (John Wiley & Sons)Copyright Statement
Country of Publication:
United States
Language:
English

References (48)

Cigarette Smoking and Risk of Lung Cancer in Korean Men: The Seoul Male Cancer Cohort Study journal January 2007
A Unification of Mediation and Interaction journal September 2014
Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950–2003: An Overview of Cancer and Noncancer Diseases journal March 2012
Cohort Profile: The Namwon Study and the Dong-gu Study journal March 2013
Body mass index and percent body fat: a meta analysis among different ethnic groups journal December 1998
Gallstones and the risk of biliary tract cancer: a population-based study in China journal November 2007
Body Size Indicators and Risk of Gallbladder Cancer: Pooled Analysis of Individual-Level Data from 19 Prospective Cohort Studies journal April 2017
Cohort Profile of the Japan Collaborative Cohort Study at Final Follow-up journal January 2013
Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies journal January 2004
Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta‐analysis of observational studies journal July 2016
Total and Cancer Mortality After Supplementation With Vitamins and Minerals: Follow-up of the Linxian General Population Nutrition Intervention Trial journal March 2009
A Cohort Study on the Relation of Lifestyle, Personality and Biologic Markers to Cancer in Miyagi, Japan : Study Design, Response Rate and Profiles of the Cohort Subjects journal January 1995
Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project journal August 2019
Cancer screenee cohort study of the National Cancer Center in South Korea journal August 2014
Study Design and Organization of the JPHC Study journal January 2001
Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study journal July 2010
Persistence of Type-Specific Human Papillomavirus Infection and Increased Long-term Risk of Cervical Cancer journal September 2011
Mediation analysis in epidemiology: methods, interpretation and bias journal September 2013
Insulin mediated DNA damage in mammalian colon cells and human lymphocytes in vitro journal May 2013
A Prospective Cohort Study on National Health Insurance Beneficiaries in Ohsaki, Miyagi Prefecture, Japan: Study Design, Profiles of the Subjects and Medical Cost During the First Year journal January 1998
Determinants for gallstone formation – a new data cohort study and a systematic review with meta-analysis* journal May 2016
The inflammatory inception of gallbladder cancer journal April 2016
Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis journal April 2004
The association between BMI and gallbladder cancer risk: a meta-analysis journal May 2016
Epidemiology of Gallstone Disease in Italy: Prevalence Data of the Multicenter Italian Study on Cholelithiasis (M.I.COL.) journal January 1995
Med4way: a Stata command to investigate mediating and interactive mechanisms using the four-way effect decomposition journal November 2018
Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies journal November 2016
Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort journal June 2012
Cohort Profile: The Golestan Cohort Study--a prospective study of oesophageal cancer in northern Iran journal March 2009
Causal Diagrams for Epidemiologic Research journal January 1999
Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: Results from a European multicentre case–control study journal January 2007
Coordinating Centers in Cancer Epidemiology Research: the Asia Cohort Consortium Coordinating Center journal October 2011
Chronic inflammation and gallbladder cancer journal April 2014
Asia Cohort Consortium: Challenges for Collaborative Research journal January 2012
Hepatitis B e Antigen and the Risk of Hepatocellular Carcinoma journal July 2002
The Role of Diet in the Pathogenesis of Cholesterol Gallstones journal September 2019
Rationale, design, and profile of the Three-Prefecture Cohort in Japan: A 15-year follow-up journal April 2017
Body fatness associations with cancer: evidence from recent epidemiological studies and future directions journal December 2022
Cohort Profile: The Shanghai Men’s Health Study journal March 2015
Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma journal April 1992
Penalized Survival Models and Frailty journal March 2003
Association of Blood Pressure and Cardiovascular Mortality in India: Mumbai Cohort Study journal October 2009
A 24-year controlled follow-up of patients with silent gallstones showed no long-term risk of symptoms or adverse events leading to cholecystectomy journal April 2011
The global, regional, and national burden of gallbladder and biliary tract cancer and its attributable risk factors in 195 countries and territories, 1990 to 2017: A systematic analysis for the Global Burden of Disease Study 2017 journal March 2021
The Shanghai Women's Health Study: Rationale, Study Design, and Baseline Characteristics journal October 2005
Risk factors for intrahepatic cholangiocarcinoma in a low‐risk population: A nationwide case‐control study journal November 2006
Body Mass Index and Risk of Gallbladder Cancer: Systematic Review and Meta-Analysis of Observational Studies journal September 2015
Parametric Frailty and Shared Frailty Survival Models journal March 2002

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