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Title: Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortium

Abstract

Abstract Body fatness is considered a probable risk factor for biliary tract cancer (BTC), whereas cholelithiasis is an established factor. Nevertheless, although obesity is an established risk factor for cholelithiasis, previous studies of the association of body mass index (BMI) and BTC did not take the effect of cholelithiasis fully into account. To better understand the effect of BMI on BTC, we conducted a pooled analysis using population‐based cohort studies in Asians. In total, 905 530 subjects from 21 cohort studies participating in the Asia Cohort Consortium were included. BMI was categorized into four groups: underweight (<18.5 kg/m 2 ); normal (18.5‐22.9 kg/m 2 ); overweight (23‐24.9 kg/m 2 ); and obese (25+ kg/m 2 ). The association between BMI and BTC incidence and mortality was assessed using hazard ratios (HR) and 95% confidence intervals (CIs) by Cox regression models with shared frailty. Mediation analysis was used to decompose the association into a direct and an indirect (mediated) effect. Compared to normal BMI, high BMI was associated with BTC mortality (HR 1.19 [CI 1.02‐1.38] for males, HR 1.30 [1.14‐1.49] for females). Cholelithiasis had significant interaction with BMI on BTC risk. BMI was associated with BTC risk directly and through cholelithiasis in females, whereas themore » association was unclear in males. When cholelithiasis was present, BMI was not associated with BTC death in either males or females. BMI was associated with BTC death among females without cholelithiasis. This study suggests BMI is associated with BTC mortality in Asians. Cholelithiasis appears to contribute to the association; and moreover, obesity appears to increase BTC risk without cholelithiasis.« less

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [3]; ORCiD logo [4];  [5];  [6]; ORCiD logo [7];  [8]; ORCiD logo [9];  [10]; ORCiD logo [11];  [12];  [13];  [14]; ORCiD logo [15];  [16]; ORCiD logo [17]; ORCiD logo [18]; ORCiD logo [19];  [20] more »;  [21];  [8];  [22];  [10];  [23];  [11];  [24];  [14];  [14]; ORCiD logo [16]; ORCiD logo [14];  [25]; ORCiD logo [26]; ORCiD logo [27];  [28];  [18];  [21];  [29];  [30];  [31]; ORCiD logo [32]; ORCiD logo [33]; ORCiD logo [11]; ORCiD logo [4]; ORCiD logo [34]; ORCiD logo [35] « less
+ Show Author Affiliations
  1. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan
  2. Division of Cancer Information and Control, Department of Preventive Medicine Aichi Cancer Center Research Institute Nagoya Japan, Division of Descriptive Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan
  3. Division of Cancer Information and Control, Department of Preventive Medicine Aichi Cancer Center Research Institute Nagoya Japan
  4. Division of Prevention National Cancer Center Institute for Cancer Control Tokyo Japan
  5. Division of Prevention National Cancer Center Institute for Cancer Control Tokyo Japan, Research Center for Child Mental Development Hamamatsu University School of Medicine Hamamatsu Japan
  6. Division of Prevention National Cancer Center Institute for Cancer Control Tokyo Japan, Hitotsubashi Institute for Advanced Study Hitotsubashi University Tokyo Japan
  7. Institute for Global Health Policy Research National Center for Global Health and Medicine Tokyo Japan
  8. Healis—Sekhsaria Institute for Public Health Navi Mumbai India
  9. Division of Cohort Research National Cancer Center Institute for Cancer Control Tokyo Japan
  10. Department of Public Health Hokkaido University Faculty of Medicine Sapporo Japan
  11. Division of Epidemiology, Department of Medicine Vanderbilt Epidemiology Center, Vanderbilt‐Ingram Cancer Center, Vanderbilt University Medical Center Nashville Tennessee USA
  12. Radiation Effects Research Foundation Hiroshima Japan
  13. Digestive Oncology Research Center, Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran
  14. Tohoku University Graduate School of Medicine Miyagi Japan
  15. Graduate School of Cancer Science and Policy, National Cancer Center Goyang Korea
  16. Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine Gifu Japan
  17. School of Medicine &, Big Data Research Center Fu Jen Catholic University Taipei Taiwan
  18. Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea
  19. Division of Cancer Control and Population Sciences UPMC Hillman Cancer Center, University of Pittsburgh Pittsburgh Pennsylvania USA, Department of Epidemiology Graduate School of Public Health, University of Pittsburgh Pittsburgh Pennsylvania USA
  20. Department of Social and Preventive Medicine Sungkyunkwan University School of Medicine Gyeonggi‐do Korea
  21. Department of Preventive Medicine Chonnam National University Medical School Gwangju Korea
  22. Division of Cohort Research National Cancer Center Institute for Cancer Control Tokyo Japan, National Institute of Health and Nutrition National Institutes of Biomedical Innovation, Health and Nutrition Tokyo Japan
  23. Department of Epidemiology Shanghai Cancer Institute Shanghai China, Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai China
  24. Digestive Diseases Research institute Tehran University of Medical Science Tehran Iran
  25. Genomics Research Center, Academia Sinica Taipei Taiwan
  26. Departments of Population Health and Environmental Medicine NYU Grossman School of Medicine New York New York USA
  27. Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea, Cancer Research Institute Seoul National University Seoul Korea
  28. Division of Cancer Control and Population Sciences UPMC Hillman Cancer Center, University of Pittsburgh Pittsburgh Pennsylvania USA
  29. Department of Public Health Sciences University of Chicago Chicago Illinois USA
  30. Stony Brook Cancer Center Stony Brook University Stony Brook New York USA, Department of Medical and Surgical Sciences University of Bologna Bologna Italy
  31. Saw Swee Hock School of Public Health National University of Singapore Singapore Singapore
  32. School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
  33. Division of Cancer Epidemiology and Genetics Occupational and Environmental Epidemiology Branch, National Cancer Institute Bethesda Maryland USA
  34. Seoul National University College of Medicine Seoul Korea
  35. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan, Department of Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
2222532
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
International Journal of Cancer
Additional Journal Information:
Journal Name: International Journal of Cancer Journal Volume: 154 Journal Issue: 7; Journal ID: ISSN 0020-7136
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
United States
Language:
English

Citation Formats

Oze, Isao, Ito, Hidemi, Koyanagi, Yuriko N., Abe, Sarah Krull, Rahman, Md. Shafiur, Islam, Md. Rashedul, Saito, Eiko, Gupta, Prakash C., Sawada, Norie, Tamakoshi, Akiko, Shu, Xiao‐Ou, Sakata, Ritsu, Malekzadeh, Reza, Tsuji, Ichiro, Kim, Jeongseon, Nagata, Chisato, You, San‐Lin, Park, Sue K., Yuan, Jian‐Min, Shin, Myung‐Hee, Kweon, Sun‐Seog, Pednekar, Mangesh S., Tsugane, Shoichiro, Kimura, Takashi, Gao, Yu‐Tang, Cai, Hui, Pourshams, Akram, Lu, Yukai, Kanemura, Seiki, Wada, Keiko, Sugawara, Yumi, Chen, Chien‐Jen, Chen, Yu, Shin, Aesun, Wang, Renwei, Ahn, Yoon‐Ok, Shin, Min‐Ho, Ahsan, Habibul, Boffetta, Paolo, Chia, Kee Seng, Qiao, You‐Lin, Rothman, Nathaniel, Zheng, Wei, Inoue, Manami, Kang, Daehee, and Matsuo, Keitaro. Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortium. United States: N. p., 2023. Web. doi:10.1002/ijc.34794.
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Oze, Isao, Ito, Hidemi, Koyanagi, Yuriko N., Abe, Sarah Krull, Rahman, Md. Shafiur, Islam, Md. Rashedul, Saito, Eiko, Gupta, Prakash C., Sawada, Norie, Tamakoshi, Akiko, Shu, Xiao‐Ou, Sakata, Ritsu, Malekzadeh, Reza, Tsuji, Ichiro, Kim, Jeongseon, Nagata, Chisato, You, San‐Lin, Park, Sue K., Yuan, Jian‐Min, Shin, Myung‐Hee, Kweon, Sun‐Seog, Pednekar, Mangesh S., Tsugane, Shoichiro, Kimura, Takashi, Gao, Yu‐Tang, Cai, Hui, Pourshams, Akram, Lu, Yukai, Kanemura, Seiki, Wada, Keiko, Sugawara, Yumi, Chen, Chien‐Jen, Chen, Yu, Shin, Aesun, Wang, Renwei, Ahn, Yoon‐Ok, Shin, Min‐Ho, Ahsan, Habibul, Boffetta, Paolo, Chia, Kee Seng, Qiao, You‐Lin, Rothman, Nathaniel, Zheng, Wei, Inoue, Manami, Kang, Daehee, & Matsuo, Keitaro. Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortium. United States. https://doi.org/10.1002/ijc.34794
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Oze, Isao, Ito, Hidemi, Koyanagi, Yuriko N., Abe, Sarah Krull, Rahman, Md. Shafiur, Islam, Md. Rashedul, Saito, Eiko, Gupta, Prakash C., Sawada, Norie, Tamakoshi, Akiko, Shu, Xiao‐Ou, Sakata, Ritsu, Malekzadeh, Reza, Tsuji, Ichiro, Kim, Jeongseon, Nagata, Chisato, You, San‐Lin, Park, Sue K., Yuan, Jian‐Min, Shin, Myung‐Hee, Kweon, Sun‐Seog, Pednekar, Mangesh S., Tsugane, Shoichiro, Kimura, Takashi, Gao, Yu‐Tang, Cai, Hui, Pourshams, Akram, Lu, Yukai, Kanemura, Seiki, Wada, Keiko, Sugawara, Yumi, Chen, Chien‐Jen, Chen, Yu, Shin, Aesun, Wang, Renwei, Ahn, Yoon‐Ok, Shin, Min‐Ho, Ahsan, Habibul, Boffetta, Paolo, Chia, Kee Seng, Qiao, You‐Lin, Rothman, Nathaniel, Zheng, Wei, Inoue, Manami, Kang, Daehee, and Matsuo, Keitaro. Wed . "Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortium". United States. https://doi.org/10.1002/ijc.34794.
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@article{osti_2222532,
title = {Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortium},
author = {Oze, Isao and Ito, Hidemi and Koyanagi, Yuriko N. and Abe, Sarah Krull and Rahman, Md. Shafiur and Islam, Md. Rashedul and Saito, Eiko and Gupta, Prakash C. and Sawada, Norie and Tamakoshi, Akiko and Shu, Xiao‐Ou and Sakata, Ritsu and Malekzadeh, Reza and Tsuji, Ichiro and Kim, Jeongseon and Nagata, Chisato and You, San‐Lin and Park, Sue K. and Yuan, Jian‐Min and Shin, Myung‐Hee and Kweon, Sun‐Seog and Pednekar, Mangesh S. and Tsugane, Shoichiro and Kimura, Takashi and Gao, Yu‐Tang and Cai, Hui and Pourshams, Akram and Lu, Yukai and Kanemura, Seiki and Wada, Keiko and Sugawara, Yumi and Chen, Chien‐Jen and Chen, Yu and Shin, Aesun and Wang, Renwei and Ahn, Yoon‐Ok and Shin, Min‐Ho and Ahsan, Habibul and Boffetta, Paolo and Chia, Kee Seng and Qiao, You‐Lin and Rothman, Nathaniel and Zheng, Wei and Inoue, Manami and Kang, Daehee and Matsuo, Keitaro},
abstractNote = {Abstract Body fatness is considered a probable risk factor for biliary tract cancer (BTC), whereas cholelithiasis is an established factor. Nevertheless, although obesity is an established risk factor for cholelithiasis, previous studies of the association of body mass index (BMI) and BTC did not take the effect of cholelithiasis fully into account. To better understand the effect of BMI on BTC, we conducted a pooled analysis using population‐based cohort studies in Asians. In total, 905 530 subjects from 21 cohort studies participating in the Asia Cohort Consortium were included. BMI was categorized into four groups: underweight (<18.5 kg/m 2 ); normal (18.5‐22.9 kg/m 2 ); overweight (23‐24.9 kg/m 2 ); and obese (25+ kg/m 2 ). The association between BMI and BTC incidence and mortality was assessed using hazard ratios (HR) and 95% confidence intervals (CIs) by Cox regression models with shared frailty. Mediation analysis was used to decompose the association into a direct and an indirect (mediated) effect. Compared to normal BMI, high BMI was associated with BTC mortality (HR 1.19 [CI 1.02‐1.38] for males, HR 1.30 [1.14‐1.49] for females). Cholelithiasis had significant interaction with BMI on BTC risk. BMI was associated with BTC risk directly and through cholelithiasis in females, whereas the association was unclear in males. When cholelithiasis was present, BMI was not associated with BTC death in either males or females. BMI was associated with BTC death among females without cholelithiasis. This study suggests BMI is associated with BTC mortality in Asians. Cholelithiasis appears to contribute to the association; and moreover, obesity appears to increase BTC risk without cholelithiasis.},
doi = {10.1002/ijc.34794},
journal = {International Journal of Cancer},
number = 7,
volume = 154,
place = {United States},
year = {Wed Nov 15 00:00:00 EST 2023},
month = {Wed Nov 15 00:00:00 EST 2023}
}
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