Title: Preparation of 2D Polyaniline/MoO _{3− x} Superlattice Nanosheets via Intercalation‐Induced Morphological Transformation for Efficient Chemodynamic Therapy

Abstract

Abstract Organic intercalation of layered nanomaterials is an attractive strategy to fabricate organic/inorganic superlattices for a wide range of promising applications. However, the synthesis of 2D organic/inorganic superlattice nanosheets remains a big challenge. Herein, the preparation of 2D polyaniline/MoO _{3− x} (PANI/MoO _{3− x} ) superlattice nanosheets via intercalation‐induced morphological transformation from MoO ₃  nanobelts, as efficient Fenton‐like reagents for chemodynamic therapy (CDT), is reported. Micrometer‐long MoO ₃  nanobelts are co‐intercalated with Na ⁺ /H ₂ O followed by the guest exchange with aniline monomer for in situ polymerization to obtain PANI/MoO _{3− x} nanosheets. Intriguingly, the PANI intercalation can induce the morphological transformation from long MoO ₃  nanobelts to 2D PANI/MoO _{3− x} nanosheets along with the partial reduction of Mo ⁶⁺ to Mo ⁵⁺ , and generation of rich oxygen vacancies. More importantly, thanks to the PANI intercalation‐induced activation, the PANI/MoO _{3− x} nanosheets exhibit excellent Fenton‐like catalytic activity for generation of hydroxyl radical (·OH) by decomposing H ₂ O ₂  compared with the MoO ₃  nanobelts. It is speculated that the good conductivity of PANI can facilitate electron transport during the Fenton‐like reaction, thereby enhancing the efficiency of CDT. Thus, the polyvinylpyrrolidone‐modified PANI/MoO _{3− x} nanosheets can functionmore » as Fenton‐like reagents for highly efficient CDT to kill cancer cells and eradicate tumors.« less

Authors:

Hu, Tingting ^[1]; Xue, Baoli ^[2]; Meng, Fanqi ^[3]; Ma, Lu ^[4]; Du, Yonghua ^[4]; Yu, Shilong ^[5]; Ye, Ruquan ^[6]; Li, Hai ^[5]; Zhang, Qinghua ^[3]; Gu, Lin ^[7]; Zhou, Zhan ^[2]; Liang, Ruizheng  ^[1];

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Tan, Chaoliang ^[8]

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+ Show Author Affiliations

1. State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China
2. College of Chemistry and Chemical Engineering Henan Key Laboratory of Function‐Oriented Porous Materials Luoyang Normal University Luoyang 471934 P. R. China
3. Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 P. R. China
4. National Synchrotron Light Source II Brookhaven National Laboratory Upton Upton NY 11973 USA
5. Institute of Advanced Materials (IAM) and Key Laboratory of Flexible Electronics (KLoFE) Nanjing Tech University (NanjingTech) 30 South Puzhu Road Nanjing 211816 P. R. China
6. Department of Chemistry City University of Hong Kong Kowloon Hong Kong SAR 999077 P. R. China, Shenzhen Research Institute City University of Hong Kong Shenzhen 518057 P. R. China
7. School of Materials Science and Engineering Tsinghua University Beijing 100084 P. R. China
8. Department of Chemistry City University of Hong Kong Kowloon Hong Kong SAR 999077 P. R. China, Shenzhen Research Institute City University of Hong Kong Shenzhen 518057 P. R. China, Center of Super‐Diamond and Advanced Films (COSDAF) City University of Hong Kong Kowloon Hong Kong SAR 999077 P. R. China

Publication Date:

Sun Jan 15 00:00:00 EST 2023

Sponsoring Org.:

USDOE

OSTI Identifier:

1971570

Resource Type:

Publisher's Accepted Manuscript

Journal Name:

Advanced Healthcare Materials

Additional Journal Information:

Journal Name: Advanced Healthcare Materials Journal Volume: 12 Journal Issue: 11; Journal ID: ISSN 2192-2640

Publisher:

Wiley Blackwell (John Wiley & Sons)

Country of Publication:

Germany

Language:

English