T-Toxin Virulence Genes: Unconnected Dots in a Sea of Repeats

Haridas, Sajeet; González, Jennifer B.; Riley, Robert; Koriabine, Maxim; Yan, Mi; Ng, Vivian; Rightmyer, Adriana; Grigoriev, Igor V.; Baker, Scott E.; Turgeon, B. Gillian; Idnurm, ed., Alexander

doi:10.1128/mbio.00261-23

Title: T-Toxin Virulence Genes: Unconnected Dots in a Sea of Repeats

Journal Article · Tue Apr 25 00:00:00 UTC 2023 · mBio (Online)

DOI: https://doi.org/10.1128/mbio.00261-23 · OSTI ID:1960447

^[1]; González, Jennifer B. ^[2]; Riley, Robert ^[1]; Koriabine, Maxim ^[1]; Yan, Mi ^[1]; Ng, Vivian ^[1]; Rightmyer, Adriana ^[2];

^[3];

^[4];

^[2]; Idnurm, ed., Alexander

United States Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California, USA
Section of Plant Pathology &, Plant-Microbe Biology, School of Integrative Plant Science, Cornell University, Ithaca, New York, USA
United States Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California, USA, Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, USA
Functional and systems Biology Group, Environmental Molecular Sciences Division, Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington, USA, DOE Joint BioEnergy Institute, Emeryville, California, USA

In 1970 a corn disease epidemic ravaged fields in the United States to great economic loss. The outbreak was caused by a never-before seen, supervirulent strain of the fungal pathogen Cochliobolus heterostrophus. This was a plant disease epidemic, however, the current COVID-19 pandemic of humans is a stark reminder that novel, highly virulent, pathogens evolve with devastating consequences, no matter what the host-animal, plant, or other organism.

View Journal Article

Cite

Export

Save

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231; AC05-76RL01830

OSTI ID:: 1960447

Report Number(s):: PNNL-SA-181983; e00261-23

Journal Information:: mBio (Online), Journal Name: mBio (Online) Journal Issue: 2 Vol. 14; ISSN 2150-7511

Publisher:: American Society for MicrobiologyCopyright Statement

Country of Publication:: United States

Language:: English

References (31)

Evolution of Host Specific Virulence in Cochliobolus heterostrophus Turgeon, B. Gillian; Lu, Shun-Wen Fungal Pathology https://doi.org/10.1007/978-94-015-9546-9_4	book	January 2000
Genetic mapping of telomeric DNA sequences in the maize pathogen Cochliobolus heterostrophus Tasma, I. M.; Bronson, C. R. Current Genetics, Vol. 34, Issue 3 https://doi.org/10.1007/s002940050391	journal	September 1998
Centromeres of filamentous fungi Smith, Kristina M.; Galazka, Jonathan M.; Phatale, Pallavi A. Chromosome Research, Vol. 20, Issue 5 https://doi.org/10.1007/s10577-012-9290-3	journal	July 2012
Characterization of the host-specific pathotoxin produced by Helminthosporium maydis, race T, affecting corn with Texas male sterile cytoplasm Kono, Y.; Daly, J. M. Bioorganic Chemistry, Vol. 8, Issue 3 https://doi.org/10.1016/0045-2068(79)90064-6	journal	September 1979
Genetic and Genomic Dissection of the Cochliobolus heterostrophus Tox1 Locus Controlling Biosynthesis of the Polyketide Virulence Factor T‐toxin Turgeon, B. Gillian; Baker, Scott E. Advances in Genetics, Vol. 57 https://doi.org/10.1016/S0065-2660(06)57006-3	book	January 2007
On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi Pfannenstiel, Brandon T.; Keller, Nancy P. Biotechnology Advances, Vol. 37, Issue 6 https://doi.org/10.1016/j.biotechadv.2019.02.001	journal	November 2019
Helitron and CACTA DNA transposons actively reshape the common wheat - AK58 genome Wang, Zhiyong; Zhao, Guangyao; Yang, Qinghua Genomics, Vol. 114, Issue 2 https://doi.org/10.1016/j.ygeno.2022.110288	journal	March 2022
Telomere-to-telomere genome sequence of the model mould pathogen Aspergillus fumigatus Bowyer, Paul; Currin, Andrew; Delneri, Daniela Nature Communications, Vol. 13, Issue 1 https://doi.org/10.1038/s41467-022-32924-7	journal	September 2022
FinisherSC: a repeat-aware tool for upgrading de novo assembly using long reads Lam, Ka-Kit; LaButti, Kurt; Khalak, Asif Bioinformatics, Vol. 31, Issue 19 https://doi.org/10.1093/bioinformatics/btv280	journal	June 2015
A restriction fragment length polymorphism map and electrophoretic karyotype of the fungal maize pathogen Cochliobolus heterostrophus. Tzeng, T. H.; Lyngholm, L. K.; Ford, C. F. Genetics, Vol. 130, Issue 1 https://doi.org/10.1093/genetics/130.1.81	journal	January 1992
The Translocation-Associated Tox1 Locus of Cochliobolus heterostrophus Is Two Genetic Elements on Two Different Chromosomes Kodama, M.; Rose, M. S.; Yang, G. Genetics, Vol. 151, Issue 2 https://doi.org/10.1093/genetics/151.2.585	journal	February 1999
Giant Starship Elements Mobilize Accessory Genes in Fungal Genomes Gluck-Thaler, Emile; Ralston, Timothy; Konkel, Zachary Molecular Biology and Evolution, Vol. 39, Issue 5 https://doi.org/10.1093/molbev/msac109	journal	May 2022
MycoCosm portal: gearing up for 1000 fungal genomes Grigoriev, Igor V.; Nikitin, Roman; Haridas, Sajeet Nucleic Acids Research, Vol. 42, Issue D1 https://doi.org/10.1093/nar/gkt1183	journal	December 2013
Clues to an Evolutionary Mystery: The Genes for T-Toxin, Enabler of the Devastating 1970 Southern Corn Leaf Blight Epidemic, Are Present in Ancestral Species, Suggesting an Ancient Origin Condon, Bradford J.; Elliott, Candace; González, Jonathan B. Molecular Plant-Microbe Interactions®, Vol. 31, Issue 11 https://doi.org/10.1094/MPMI-03-18-0070-R	journal	November 2018
Six New Genes Required for Production of T-Toxin, a Polyketide Determinant of High Virulence of Cochliobolus heterostrophus to Maize Inderbitzin, Patrik; Asvarak, Thipa; Turgeon, B. Gillian Molecular Plant-Microbe Interactions, Vol. 23, Issue 4 https://doi.org/10.1094/MPMI-23-4-0458	journal	April 2010
A Decarboxylase Encoded at the Cochliobolus heterostrophus Translocation-Associated Tox1B Locus Is Required for Polyketide (T-toxin) Biosynthesis and High Virulence on T-cytoplasm Maize Rose, Mark S.; Yun, Sung-Hwan; Asvarak, Thipa Molecular Plant-Microbe Interactions®, Vol. 15, Issue 9 https://doi.org/10.1094/MPMI.2002.15.9.883	journal	September 2002
An Improved Genome Sequence Resource of Bipolaris maydis, Causal Agent of Southern Corn Leaf Blight Wang, Yafei; Kang, Houxiang; Yao, Jinai Phytopathology®, Vol. 112, Issue 6 https://doi.org/10.1094/PHYTO-11-21-0490-A	journal	June 2022
Phyllosticta maydis species nova, the Incitant of Yellow Leaf Blight of Maize Arny, D. C. Phytopathology, Vol. 61, Issue 10 https://doi.org/10.1094/Phyto-61-1170	journal	January 1971
Host Specificity of a Toxin from Phyllosticta maydis for Texas Cytoplasmically Male-Sterile Maize Comstock, J. C. Phytopathology, Vol. 63, Issue 11 https://doi.org/10.1094/Phyto-63-1357	journal	January 1973
A Selective Toxin Produced by Phyllosticta maydis Yoder, O. C. Phytopathology, Vol. 63, Issue 11 https://doi.org/10.1094/Phyto-63-1361	journal	January 1973
Virulence, Temperature Optima, and Competitive Abilities of Isolines of Races T and O of Bipolaris maydis Leonard, K. J. Phytopathology, Vol. 77, Issue 10 https://doi.org/10.1094/Phyto-67-1273	journal	January 1977
Reduced Fitness Associated withTOX1 ofCochliobolus heterostrophus Klittich, C. J. R. Phytopathology, Vol. 76, Issue 12 https://doi.org/10.1094/Phyto-76-1294	journal	January 1986
NPS6 , Encoding a Nonribosomal Peptide Synthetase Involved in Siderophore-Mediated Iron Metabolism, Is a Conserved Virulence Determinant of Plant Pathogenic Ascomycetes Oide, Shinichi; Moeder, Wolfgang; Krasnoff, Stuart The Plant Cell, Vol. 18, Issue 10 https://doi.org/10.1105/tpc.106.045633	journal	October 2006
Synteny and Collinearity in Plant Genomes Tang, H.; Bowers, J. E.; Wang, X. Science, Vol. 320, Issue 5875 https://doi.org/10.1126/science.1153917	journal	April 2008
Repetitive Elements Contribute to the Diversity and Evolution of Centromeres in the Fungal Genus Verticillium Seidl, Michael F.; Kramer, H. Martin; Cook, David E. mBio, Vol. 11, Issue 5 https://doi.org/10.1128/mBio.01714-20	journal	October 2020
Ascospore abortion in crosses of Cochliobolus heterostrophus heterozygous for the virulence locus Tox1 Bronson, Charlotte R. Genome, Vol. 30, Issue 1 https://doi.org/10.1139/g88-003	journal	February 1988
A reciprocal translocation and possible insertion(s) tightly associated with host-specific virulence inCochliobolus heterostrophus Chang, Hsin-Ru; Bronson, Charlotte R. Genome, Vol. 39, Issue 3 https://doi.org/10.1139/g96-070	journal	June 1996
Characterization and potential evolutionary impact of transposable elements in the genome of Cochliobolus heterostrophus Santana, Mateus F.; Silva, José CF; Mizubuti, Eduardo SG BMC Genomics, Vol. 15, Issue 1 https://doi.org/10.1186/1471-2164-15-536	journal	June 2014
Comparative Genome Structure, Secondary Metabolite, and Effector Coding Capacity across Cochliobolus Pathogens Condon, Bradford J.; Leng, Yueqiang; Wu, Dongliang PLoS Genetics, Vol. 9, Issue 1 https://doi.org/10.1371/journal.pgen.1003233	journal	January 2013
LTR Retrotransposons in Fungi Muszewska, Anna; Hoffman-Sommer, Marta; Grynberg, Marcin PLoS ONE, Vol. 6, Issue 12 https://doi.org/10.1371/journal.pone.0029425	journal	December 2011
ChLae1 and ChVel1 Regulate T-toxin Production, Virulence, Oxidative Stress Response, and Development of the Maize Pathogen Cochliobolus heterostrophus Wu, Dongliang; Oide, Shinichi; Zhang, Ning PLoS Pathogens, Vol. 8, Issue 2 https://doi.org/10.1371/journal.ppat.1002542	journal	February 2012

Similar Records

Genetic and Genomic Dissection of the Cochliobolus heterostrophus Tox1 Locus Controlling Biosynthesis of the Polyketide Virulence Factor T-toxin

Book · Fri Apr 27 04:00:00 UTC 2007 · OSTI ID:1006334

Turgeon, Barbara G; Baker, Scott E

Setosphaeria turcica ATR turns off appressorium‐mediated maize infection and triggers melanin‐involved self‐protection in response to genotoxic stress

Journal Article · Wed Jan 08 00:00:00 UTC 2020 · Molecular Plant Pathology · OSTI ID:1581663

Zeng, Fanli; Meng, Yanan; Hao, Zhimin; +5 more

Edge effects, not connectivity, determine the incidence and development of a foliar fungal plant disease.

Journal Article · Mon Aug 01 04:00:00 UTC 2011 · Ecology · OSTI ID:1025882

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Cochliobolus
PacBio
Southern Corn Leaf Blight
filamentous fungi
fungi
repeats
secondary metabolism
secondary metabolite
transposable element
unlinked loci
virulence determinants

Title: T-Toxin Virulence Genes: Unconnected Dots in a Sea of Repeats

Citation Formats

References (31)

Similar Records

Related Subjects