Investigation of the photoluminescent properties, scintillation behaviour and toxicological profile of various magnesium tungstate nanoscale motifs

Hurley, Nathaniel; Srinivas, Sailesh; Fang, Justin; Sun, Manli; Hong, Simon; Chien, Chia Te; Guo, Alan; Khan, Tamor A.; Li, Mingxing; Cotlet, Mircea; Moretti, Federico; Bourret, Edith; Radin, Daniel; Tsirka, Stella E.; Shelly, Maya; Wong, Stanislaus S.

doi:10.1098/rsos.220994

Title: Investigation of the photoluminescent properties, scintillation behaviour and toxicological profile of various magnesium tungstate nanoscale motifs

Journal Article · Wed Dec 07 00:00:00 UTC 2022 · Royal Society Open Science

DOI: https://doi.org/10.1098/rsos.220994 · OSTI ID:1922714

Hurley, Nathaniel ^[1]; Srinivas, Sailesh ^[1];

^[1]; Sun, Manli ^[1]; Hong, Simon ^[1];

^[1]; Guo, Alan ^[1]; Khan, Tamor A. ^[1]; Li, Mingxing ^[2]; Cotlet, Mircea ^[2]; Moretti, Federico ^[3]; Bourret, Edith ^[3]; Radin, Daniel ^[1]; Tsirka, Stella E. ^[1]; Shelly, Maya ^[1];

^[1]

State University of New York (SUNY), Stony Brook, NY (United States)
Brookhaven National Laboratory (BNL), Upton, NY (United States). Center for Functional Nanomaterials (CFN)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

We have synthesized several morphologies and crystal structures of MgWO₄ using a one-pot hydrothermal method, producing not only monoclinic stars and large nanoparticles but also triclinic wool balls and sub-10 nm nanoparticles. Herein we describe the importance of reaction parameters in demonstrating morphology control of as-prepared MgWO₄. Moreover, we correlate structure and composition with the resulting photoluminescence and radioluminescence properties. Specifically, triclinic-phase samples yielded a photoluminescence emission of 421 nm, whereas monoclinic-phase materials gave rise to an emission maximum of 515 nm. The corresponding radioluminescence data were characterized by a broad emission peak, located at 500 nm for all samples. Annealing the wool balls and sub-10 nm particles to transform the crystal structure from a triclinic to a monoclinic phase yielded a radioluminescence (RL) emission signal that was two orders of magnitude greater than that of their unannealed counterparts. Finally, to confirm the practical utility of these materials for biomedical applications, a series of sub-10 nm particles, including as-prepared and annealed samples, were functionalized with biocompatible PEG molecules, and subsequently were found to be readily taken up by various cell lines as well as primary cultured hippocampal neurons with low levels of toxicity, thereby highlighting for the first time the potential of this particular class of metal oxides as viable and readily generated platforms for a range of biomedical applications.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-05CH11231; SC0012704

OSTI ID:: 1922714

Report Number(s):: BNL-223926-2023-JAAM

Journal Information:: Royal Society Open Science, Journal Name: Royal Society Open Science Journal Issue: 12 Vol. 9; ISSN 2054-5703

Publisher:: The Royal Society PublishingCopyright Statement

Country of Publication:: United States

Language:: English

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supplementary Information version 15 from Investigation of the photoluminescent properties, scintillation behaviour and toxicological profile of various magnesium tungstate nanoscale motifs Hurley, Nathaniel; Srinivas, Sailesh; Fang, Justin https://doi.org/10.6084/m9.figshare.21617571.v1 The current record is supplemented by this text	text	January 2022
Supplementary material from "Investigation of the photoluminescent properties, scintillation behaviour and toxicological profile of various magnesium tungstate nanoscale motifs" Hurley, Nathaniel; Srinivas, Sailesh; Fang, Justin https://doi.org/10.6084/m9.figshare.c.6315600.v1 The current record is supplemented by this collection	collection	January 2022

Title: Investigation of the photoluminescent properties, scintillation behaviour and toxicological profile of various magnesium tungstate nanoscale motifs

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