Coupling of the Liquid Sampling–Atmospheric Pressure Glow Discharge to Orbitrap Mass Analyzers for Uranium Isotope Ratio Analysis: Evolution of the Methodology and Implications to the Field
Abstract
Just over a decade ago, a truly outside-of-the-box approach to isotope ratio mass spectrometry (IRMS) was undertaken between research groups at Clemson University and the Pacific Northwest National Laboratory. The original motivation dealt with projections as to whether or not microplasmas could be developed into practical elemental ionization sources, perhaps for transportable analysis applications. In particular, the use of the liquid sampling–atmospheric pressure glow discharge (LS-APGD) was pursued. Its interfacing to an ultra-high resolution Orbitrap platform, proved not only facile, but opened up a wealth of potential applications. Here, we lay out a historical, tutorial description of the interfacing and the evolution of the methodology regarding IRMS of uranium. Practical challenges and opportunities are described, which hopefully provide guidance to further applications in high resolution IRMS. It is hoped that, while detailed and lengthy, the didactic nature of the presentation provides experimental insights and tips, and also serves as an homage to our very good friend, Professor Gary M. Hieftje, whose scientific inspiration and comradery have been immeasurably important in our own careers.
- Authors:
-
[2]
- Pacific Northwest National Laboratory, Richland, WA, USA
- Department of Chemistry, Clemson University, Clemson, SC, USA
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1909042
- Resource Type:
- Published Article
- Journal Name:
- Applied Spectroscopy
- Additional Journal Information:
- Journal Name: Applied Spectroscopy Journal Volume: 77 Journal Issue: 8; Journal ID: ISSN 0003-7028
- Publisher:
- SAGE Publications
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Koppenaal, David W., and Marcus, R. Kenneth. Coupling of the Liquid Sampling–Atmospheric Pressure Glow Discharge to Orbitrap Mass Analyzers for Uranium Isotope Ratio Analysis: Evolution of the Methodology and Implications to the Field. United States: N. p., 2023.
Web. doi:10.1177/00037028221147927.
Koppenaal, David W., & Marcus, R. Kenneth. Coupling of the Liquid Sampling–Atmospheric Pressure Glow Discharge to Orbitrap Mass Analyzers for Uranium Isotope Ratio Analysis: Evolution of the Methodology and Implications to the Field. United States. https://doi.org/10.1177/00037028221147927
Koppenaal, David W., and Marcus, R. Kenneth. Thu .
"Coupling of the Liquid Sampling–Atmospheric Pressure Glow Discharge to Orbitrap Mass Analyzers for Uranium Isotope Ratio Analysis: Evolution of the Methodology and Implications to the Field". United States. https://doi.org/10.1177/00037028221147927.
@article{osti_1909042,
title = {Coupling of the Liquid Sampling–Atmospheric Pressure Glow Discharge to Orbitrap Mass Analyzers for Uranium Isotope Ratio Analysis: Evolution of the Methodology and Implications to the Field},
author = {Koppenaal, David W. and Marcus, R. Kenneth},
abstractNote = {Just over a decade ago, a truly outside-of-the-box approach to isotope ratio mass spectrometry (IRMS) was undertaken between research groups at Clemson University and the Pacific Northwest National Laboratory. The original motivation dealt with projections as to whether or not microplasmas could be developed into practical elemental ionization sources, perhaps for transportable analysis applications. In particular, the use of the liquid sampling–atmospheric pressure glow discharge (LS-APGD) was pursued. Its interfacing to an ultra-high resolution Orbitrap platform, proved not only facile, but opened up a wealth of potential applications. Here, we lay out a historical, tutorial description of the interfacing and the evolution of the methodology regarding IRMS of uranium. Practical challenges and opportunities are described, which hopefully provide guidance to further applications in high resolution IRMS. It is hoped that, while detailed and lengthy, the didactic nature of the presentation provides experimental insights and tips, and also serves as an homage to our very good friend, Professor Gary M. Hieftje, whose scientific inspiration and comradery have been immeasurably important in our own careers.},
doi = {10.1177/00037028221147927},
journal = {Applied Spectroscopy},
number = 8,
volume = 77,
place = {United States},
year = {Thu Jan 12 00:00:00 EST 2023},
month = {Thu Jan 12 00:00:00 EST 2023}
}
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Works referenced in this record:
Spectroscopic and electrical studies of a solution-cathode glow discharge
journal, January 2005
- Webb, Michael R.; Andrade, Francisco J.; Gamez, Gerardo
- Journal of Analytical Atomic Spectrometry, Vol. 20, Issue 11
Evaluation of the operating parameters of the liquid sampling-atmospheric pressure glow discharge (LS-APGD) ionization source for elemental mass spectrometry
journal, July 2014
- Zhang, Lynn X.; Manard, Benjamin T.; Kappel, Stefanie Konegger
- Analytical and Bioanalytical Chemistry, Vol. 406, Issue 29
Direct solution analysis by glow discharge: electrolyte-cathode discharge spectrometry
journal, January 1994
- Cserfalvi, Tamas; Mezei, Pal
- Journal of Analytical Atomic Spectrometry, Vol. 9, Issue 3, p. 345-349
Roles of collisional dissociation modalities on spectral composition and isotope ratio measurement performance of the liquid sampling – atmospheric pressure glow discharge / orbitrap mass spectrometer coupling
journal, June 2021
- Williams, Tyler J.; Hoegg, Edward D.; Bills, Jacob R.
- International Journal of Mass Spectrometry, Vol. 464
Beneficial Ion/Molecule Reactions in Elemental Mass Spectrometry
journal, January 1997
- Eiden, Gregory C.; Barinaga, Charles J.; Koppenaal, David W.
- Rapid Communications in Mass Spectrometry, Vol. 11, Issue 1
Using Orbitrap mass spectrometry to assess the isotopic compositions of individual compounds in mixtures
journal, November 2020
- Hofmann, Amy E.; Chimiak, Laura; Dallas, Brooke
- International Journal of Mass Spectrometry, Vol. 457
Development of direct-current, atmospheric-pressure, glow discharges generated in contact with flowing electrolyte solutions for elemental analysis by optical emission spectrometry
journal, December 2012
- Jamroz, Piotr; Greda, Krzysztof; Pohl, Pawel
- TrAC Trends in Analytical Chemistry, Vol. 41
Exploring frontiers of orbitrap performance for long transients
journal, August 2021
- Denisov, Eduard; Damoc, Eugen; Makarov, Alexander
- International Journal of Mass Spectrometry, Vol. 466
Ambient desorption/ionization mass spectrometry using a liquid sampling–atmospheric glow discharge (LS-APGD) ionization source
journal, July 2013
- Marcus, R. Kenneth; Burdette, Carolyn Q.; Manard, Benjamin T.
- Analytical and Bioanalytical Chemistry, Vol. 405, Issue 25
The Orbitrap: a new mass spectrometer
journal, January 2005
- Hu, Qizhi; Noll, Robert J.; Li, Hongyan
- Journal of Mass Spectrometry, Vol. 40, Issue 4
Trace-Level Persistent Organic Pollutant Analysis with Gas-Chromatography Orbitrap Mass Spectrometry—Enhanced Performance by Complementary Acquisition and Processing of Time-Domain Data
journal, January 2020
- Nagornov, Konstantin O.; Zennegg, Markus; Kozhinov, Anton N.
- Journal of the American Society for Mass Spectrometry, Vol. 31, Issue 2
Exploring the Potential of Electrospray-Orbitrap for Stable Isotope Analysis Using Nitrate as a Model
journal, June 2021
- Hilkert, Andreas; Böhlke, John K.; Mroczkowski, Stanley J.
- Analytical Chemistry, Vol. 93, Issue 26
Liquid Sampling-Atmospheric Pressure Glow Discharge Ionization Source for Elemental Mass Spectrometry
journal, April 2011
- Marcus, R. Kenneth; Quarles, C. Derrick; Barinaga, Charles J.
- Analytical Chemistry, Vol. 83, Issue 7
Mass spectra of diverse organic species utilizing the liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasma ionization source
journal, January 2016
- Zhang, Lynn X.; Marcus, R. Kenneth
- Journal of Analytical Atomic Spectrometry, Vol. 31, Issue 1
Fundamental studies of electrolyte-as-cathode glow discharge-atomic emission spectrometry for the determination of trace metals in flowing water
journal, July 1998
- Park, Yang; Ku, Soo; Hong, Sung
- Spectrochimica Acta Part B: Atomic Spectroscopy, Vol. 53, Issue 6-8, p. 1167-1179
Mass spectrometric analysis for nuclear safeguards
journal, January 2015
- Boulyga, Sergei; Konegger-Kappel, Stefanie; Richter, Stephan
- Journal of Analytical Atomic Spectrometry, Vol. 30, Issue 7
Determination of uranium isotope ratios using a liquid sampling atmospheric pressure glow discharge/Orbitrap mass spectrometer system
journal, August 2017
- Hoegg, Edward D.; Marcus, R. Kenneth; Koppenaal, David W.
- Rapid Communications in Mass Spectrometry, Vol. 31, Issue 18
Liquid sampling–atmospheric pressure glow discharge (LS-APGD) ionization source for elemental mass spectrometry: preliminary parametric evaluation and figures of merit
journal, September 2011
- Quarles, C. Derrick; Carado, Anthony J.; Barinaga, Charles J.
- Analytical and Bioanalytical Chemistry, Vol. 402, Issue 1
Coupling of an atmospheric pressure microplasma ionization source with an Orbitrap Fusion Lumos Tribrid 1M mass analyzer for ultra-high resolution isotopic analysis of uranium
journal, January 2019
- Hoegg, Edward D.; Godin, Simon; Szpunar, Joanna
- Journal of Analytical Atomic Spectrometry, Vol. 34, Issue 7
An Atmospheric Pressure Glow Discharge Optical Emission Source for the Direct Sampling of Liquid Media
journal, July 2001
- Marcus, R. Kenneth; Davis, W. Clay
- Analytical Chemistry, Vol. 73, Issue 13
Improved uranium isotopic ratio determinations for the liquid sampling-atmospheric pressure glow discharge orbitrap mass spectrometer by use of moving average processing
journal, January 2022
- Goodwin, Joseph V.; Manard, Benjamin T.; Ticknor, Brian W.
- Journal of Analytical Atomic Spectrometry, Vol. 37, Issue 4
Concomitant ion effects on isotope ratio measurements with liquid sampling – atmospheric pressure glow discharge ion source Orbitrap mass spectrometry
journal, January 2018
- Hoegg, Edward D.; Marcus, R. Kenneth; Hager, George J.
- Journal of Analytical Atomic Spectrometry, Vol. 33, Issue 2
Resolving Severe Elemental Isobaric Interferences with a Combined Atomic and Molecular Ionization Source–Orbitrap Mass Spectrometry Approach: The 87Sr and 87Rb Geochronology Pair
journal, August 2021
- Hoegg, Edward D.; Godin, Simon; Szpunar, Joanna
- Analytical Chemistry, Vol. 93, Issue 33
Project Vienna: A Novel Precell Mass Filter for Collision/Reaction Cell MC-ICPMS/MS
journal, July 2021
- Craig, Grant; Wehrs, Henning; Bevan, Dan G.
- Analytical Chemistry, Vol. 93, Issue 30
Rapid Determination of Uranium Isotopic Abundance from Cotton Swipes: Direct Extraction via a Planar Surface Reader and Coupling to a Microplasma Ionization Source
journal, June 2020
- Paing, Htoo W.; Manard, Benjamin T.; Ticknor, Brian W.
- Analytical Chemistry, Vol. 92, Issue 12
An atmospheric pressure glow discharge optical emission source for the direct sampling of liquid media
journal, January 2001
- Davis, W. Clay; Marcus, R. Kenneth
- Journal of Analytical Atomic Spectrometry, Vol. 16, Issue 9
Preliminary Figures of Merit for Isotope Ratio Measurements: The Liquid Sampling-Atmospheric Pressure Glow Discharge Microplasma Ionization Source Coupled to an Orbitrap Mass Analyzer
journal, April 2016
- Hoegg, Edward D.; Barinaga, Charles J.; Hager, George J.
- Journal of The American Society for Mass Spectrometry, Vol. 27, Issue 8
Combined atomic and molecular (CAM) ionization with the liquid sampling‐atmospheric pressure glow discharge microplasma
journal, August 2021
- Kenneth Marcus, R.; Hoegg, Edward D.; Hall, Katja A.
- Mass Spectrometry Reviews
Improved Uranium Isotope Ratio Analysis in Liquid Sampling–Atmospheric Pressure Glow Discharge/Orbitrap FTMS Coupling through the Use of an External Data Acquisition System
journal, April 2021
- Bills, Jacob R.; Nagornov, Konstantin O.; Kozhinov, Anton N.
- Journal of the American Society for Mass Spectrometry, Vol. 32, Issue 5
Performance of an inductively coupled plasma source ion trap mass spectrometer
journal, January 1994
- Koppenaal, David W.; Barinaga, Charles J.; Smith, Monty R.
- Journal of Analytical Atomic Spectrometry, Vol. 9, Issue 9
Liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasmas for diverse spectrochemical analysis applications
journal, January 2017
- Marcus, R. Kenneth; Manard, Benjamin T.; Quarles, C. Derrick
- Journal of Analytical Atomic Spectrometry, Vol. 32, Issue 4
Initial Benchmarking of the Liquid Sampling-Atmospheric Pressure Glow Discharge-Orbitrap System Against Traditional Atomic Mass Spectrometry Techniques for Nuclear Applications
journal, October 2018
- Hoegg, Edward D.; Manard, Benjamin T.; Wylie, E. Miller
- Journal of The American Society for Mass Spectrometry, Vol. 30, Issue 2
Ultra-High Resolution Elemental/Isotopic Mass Spectrometry (m/Δm > 1,000,000): Coupling of the Liquid Sampling-Atmospheric Pressure Glow Discharge with an Orbitrap Mass Spectrometer for Applications in Biological Chemistry and Environmental Analysis
journal, April 2019
- Hoegg, Edward D.; Godin, Simon; Szpunar, Joanna
- Journal of The American Society for Mass Spectrometry, Vol. 30, Issue 7
Collision and reaction cells in atomic mass spectrometry: development, status, and applicationsThe opinions expressed in the following article are entirely those of the authors and do not necessarily represent the views of the Royal Society of Chemistry, the Editor or the Editorial Board of JAAS.
journal, January 2004
- Koppenaal, David W.; Eiden, Gregory C.; Barinaga, Charles J.
- Journal of Analytical Atomic Spectrometry, Vol. 19, Issue 5
Spectrochemical Analysis by Using Discharge Devices with Solution Electrodes
journal, February 2009
- Webb, Michael R.; Hieftje, Gary M.
- Analytical Chemistry, Vol. 81, Issue 3
Isotope ratio characteristics and sensitivity for uranium determinations using a liquid sampling-atmospheric pressure glow discharge ion source coupled to an Orbitrap mass analyzer
journal, January 2016
- Hoegg, Edward D.; Barinaga, Charles J.; Hager, George J.
- Journal of Analytical Atomic Spectrometry, Vol. 31, Issue 12
Stable Isotope Analysis of Intact Oxyanions Using Electrospray Quadrupole-Orbitrap Mass Spectrometry
journal, January 2020
- Neubauer, Cajetan; Crémière, Antoine; Wang, Xingchen T.
- Analytical Chemistry, Vol. 92, Issue 4
Mass spectrometric characteristics and preliminary figures of merit for polyaromatic hydrocarbons via the liquid sampling-atmospheric pressure glow discharge microplasma
journal, January 2020
- Williams, Tyler J.; Bills, Jacob R.; Marcus, R. Kenneth
- Journal of Analytical Atomic Spectrometry, Vol. 35, Issue 11
Coupling the liquid sampling – atmospheric pressure glow discharge, a combined atomic and molecular (CAM) ionization source, to a reduced-format mass spectrometer for the analysis of diverse species
journal, January 2020
- Williams, Tyler J.; Marcus, R. Kenneth
- Journal of Analytical Atomic Spectrometry
Intercomparison of the Radio-Chronometric Ages of Plutonium-Certified Reference Materials with Distinct Isotopic Compositions
journal, August 2019
- Mathew, Kattathu; Kayzar-Boggs, Theresa; Varga, Zsolt
- Analytical Chemistry, Vol. 91, Issue 18
Coupling of Laser Ablation and the Liquid Sampling-Atmospheric Pressure Glow Discharge Plasma for Simultaneous, Comprehensive Mapping: Elemental, Molecular, and Spatial Analysis
journal, August 2020
- Paing, Htoo W.; Bryant, Tyler J.; Quarles, C. Derrick
- Analytical Chemistry, Vol. 92, Issue 18
High-Resolution Inductively Coupled Plasma Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
journal, September 1997
- Milgram, K. Eric; White, Forest M.; Goodner, Kevin L.
- Analytical Chemistry, Vol. 69, Issue 18
Plasma source ion trap mass spectrometry: Enhanced abundance sensitivity by resonant ejection of atomic ions
journal, November 1996
- Eiden, G. C.; Barinaga, C. J.; Koppenaal, D. W.
- Journal of the American Society for Mass Spectrometry, Vol. 7, Issue 11
Characterization of the Spectral Accuracy of an Orbitrap Mass Analyzer Using Isotope Ratio Mass Spectrometry
journal, January 2018
- Khodjaniyazova, Sitora; Nazari, Milad; Garrard, Kenneth P.
- Analytical Chemistry, Vol. 90, Issue 3
A dynamic reaction cell for inductively coupled plasma mass spectrometry (ICP-DRC-MS). II. Reduction of interferences produced within the cell
journal, November 1999
- Tanner, Scott D.; Baranov, Vladimir I.
- Journal of the American Society for Mass Spectrometry, Vol. 10, Issue 11
Preliminary Assessment of Potential for Metal–Ligand Speciation in Aqueous Solution via the Liquid Sampling–Atmospheric Pressure Glow Discharge (LS-APGD) Ionization Source: Uranyl Acetate
journal, June 2015
- Zhang, Lynn X.; Manard, Benjamin T.; Powell, Brian A.
- Analytical Chemistry, Vol. 87, Issue 14
Reaction cells and collision cells for ICP-MS: a tutorial review
journal, September 2002
- Tanner, Scott D.; Baranov, Vladimir I.; Bandura, Dmitry R.
- Spectrochimica Acta Part B: Atomic Spectroscopy, Vol. 57, Issue 9
High-Throughput Elemental Analysis of Small Aqueous Samples by Emission Spectrometry with a Compact, Atmospheric-Pressure Solution-Cathode Glow Discharge
journal, October 2007
- Webb, Michael R.; Andrade, Francisco J.; Hieftje, Gary M.
- Analytical Chemistry, Vol. 79, Issue 20
Reaction chemistry and collisional processes in multipole devices for resolving isobaric interferences in ICP-MS
journal, July 2001
- Bandura, D. R.; Baranov, V. I.; Tanner, S. D.
- Fresenius' Journal of Analytical Chemistry, Vol. 370, Issue 5
Operating mechanism of the electrolyte cathode atmospheric glow discharge
journal, July 1996
- Cserfalvi, T.; Mezei, P.
- Analytical and Bioanalytical Chemistry, Vol. 355, Issue 7-8
Orbitrap journey: taming the ion rings
journal, September 2019
- Makarov, Alexander
- Nature Communications, Vol. 10, Issue 1